Even small defects in the genes that
assemble tubulin are associated with serious developmental disorders, such as Kenny - Caffey syndrome and Giant Axonal Neuropathy.
Jawdat Al - Bassam at the UC Davis Department of Molecular and Cellular Biology and colleagues have now taken a close look at the proteins that
assemble tubulin, and found that they comprise a single machine, not a stepped pathway as previously thought.
Then they put all six genes into a single piece of DNA, so that they would all be transcribed together — and found that they could reconstitute the «3 - D printer» that
assemble tubulin dimers.
Not exact matches
This unique organization of
tubulin is preserved among all living plant and animal cells, because it is essential for way in which microtubules
assemble, Al - Bassam said.
Building from two subunits, alpha and beta
tubulin, this protein
assembles into microtubules that play a vital role inside cells — giving structure, pushing or pulling other things around, or providing a track on which other molecules can pull themselves along.
Assembling alpha - beta
tubulin dimers involves six known genes, Al - Bassam said.
Tubulin, a flexible protein,
assembles into a long chain to create microtubules.
Microtubule strands
assemble from subunits of alpha and beta
tubulin proteins that form dimers.
«About 400,000
tubulin dimers need to be transported within 60 minutes to
assemble a single cilium.