Typically
we associate estrone with menopause, not the the fertile years of a woman's life.
Not exact matches
2 - OH E1, a Phase I metabolite of
estrone, has weak estrogenic activity and is
associated with protection against prostate cancer.
(1) The 2 / 16α ratio: a decrease in this ratio of the
estrone metabolites, 2 - hydroxyestrone and 16α - hydroxyestrone, is
associated with an increased risk of breast and cervical cancer.
16α - OH E1, also a Phase I
estrone metabolite, is an estrogen agonist, stimulates cell mitosis and proliferation, and is
associated with increased risk of prostate cancer.
However, 16α - OH
estrone is also involved in bone building, so very low levels indicate increased risk for osteopenia / osteoporosis in men as well as women.29303132333435 Confirming this, a positive family history of osteoporosis has been found to be
associated with preferential metabolism of estrogen through the inactive 2 - OH pathway.36
Elevated levels of
estrone in obese women is
associated with higher risk of breast cancer.
Estradiol and
estrone are found in both men and women, with estriol only being
associated with pregnancy.