Sentences with phrase «associated gene changes»

For example, at least two of the autism - associated gene changes described in the paper were associated with increased risk for seizures.

Not exact matches

IRRI uses the International Rice Genebank - the most comprehensive collection of rice genetic diversity in the world with around 110,000 different types of rice - as a source of rice genes associated with traits that help rice cope with climate change.

A new mouse model of a genetically - linked type of autism reveals more about the role of genes in the disorder and the underlying brain changes associated with autism's social and learning problems.

«Identifying which of these candidate genes actually causes variation in responses to cold snaps will give us the potential to understand whether evolution to climate change can occur in both wild and domesticated animals, allowing us to better predict which species or breeds will be «winners» and «losers» and to better mitigate the effects of anthropogenic climate change on a wide range of organisms from beneficial pollinators to invasive pests,» said Theodore Morgan an associate professor of evolutionary genetics in the Division of Biology at Kansas State University and senior author of the study.

Scans showed remodeled DNA methylation patterns in the low - fat group, which changed gene expression associated with fat metabolism and inflammation in the liver; there was less fat accumulation and inflammation in the liver.

The researchers traced the white pattern to just two small changes in a gene associated with hair color.

«We believe these master genes are responsible for traumatic brain injury adversely triggering changes in many other genes,» said Xia Yang, a senior author of the study and a UCLA associate professor of integrative biology and physiology.

Cases associated with changes in each of the four genes were different from each other in terms of symptoms, intelligence level and other disease features.

Although there are several ways to remove RB from the cellular machinery, the group found that complete loss, rather than inactivation, of the RB gene was associated with changes in gene - networks closely linked to aggressive disease.

In the case of β - ionone, the smell associated with violets, McRae and colleagues managed to pinpoint the exact mutation (a change in the DNA sequence) in the odorant receptor gene OR5A1 that underlies the sensitivity to smell the compound and to perceive it as a floral note — people who are less good at smelling β - ionone also describe the smell differently, as sour or pungent, and are less likely to find it pleasant.

«It appears that genes whose expression changes from childhood to adulthood may be disproportionately associated with an increased risk for diabetes.»

Judith Zelikoff of NYU Langone Medical Center studied pre - and post-natal exposure to mice of commercially available e-cigarette vapors and aerosols with and without nicotine, finding changes to frontal cortex gene expression associated with mental health and activity issues, some of which are associated with schizophrenia, she said.

Its appearance following starvation and other stresses is associated with changes in the expression of over 500 genes, most prominently genes for the structural RNAs that are components of the ribosome — the enzyme responsible for protein synthesis.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

Changes in this gene are associated with a high risk of developing breast and ovarian cancer.

«We found that zinc oxide (ZnO) nanoparticles at doses that are relevant to what you might normally eat in a meal or a day can change the way that your intestine absorbs nutrients or your intestinal cell gene and protein expression,» said Gretchen Mahler, associate professor of bioengineering.

Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

Interestingly, the Lingula genes associated with basic metabolism show the slowest evolutionary change among lophotrochozoans.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

Genes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the ArGenes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Argenes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Arctic.

Knowing this, Dr. Soliman and colleagues decided to search the DNA of ALTS patients for specific changes in genes associated with scarring and wound healing.

Other fast - changing genes — roughly 100 — are associated with neurotransmitters, including serotonin (a mood regulator), glutamate (involved in general arousal), and dopamine (which regulates attention).

The team found changes in the activity of nearly 40 genes in three brain regions known to be associated with depression and anxiety (Science Signaling, doi.org/b4rz).

A study by the Nova Southeastern University (NSU) Save Our Seas Shark Research Center and Guy Harvey Research Institute (GHRI) and the Cornell University College of Veterinary Medicine just published in the journal BMC Genomics (lead author, postdoctoral associate Nicholas Marra,) now provides the first evidence that some shark and ray immunity genes have undergone evolutionary changes that may be tied to these novel immune system abilities.

They found changes in 433 genes that were associated with fatty liver development and progression in the mice exposed to e-cigarettes.

Surprisingly, more than 80 percent of the dependencies with biomarkers were associated with changes (up or down) in a gene's expression.

Mao's study examined mitochondria - associated gene expression in the mouse eye tissue and found significant changes in several genes involved in oxidative stress response.

Furthermore, by comparing the patterns of change in humans and chimpanzees, it was revealed that HAR - associated schizophrenia genes were under stronger evolutionary selective pressure than other schizophrenia genes.

Grace Kao, associate ethics professor at Claremont School of Theology, in Claremont, California, mentioned additions she will make to her Introduction to Christian Ethics course, such as discussing epigenetic alterations associated with war trauma for a session on war and peace, the science behind shopping and the ways that poverty can change your genes for a segment about economics, and an exploration of whether genes can predict a person's liberalism and conservatism for a session on religion and politics.

To work out the genetic basis, Duke University postdoctoral associate Bob Fitak and biology professor Sönke Johnsen and colleagues investigated changes in gene expression that take place across the rainbow trout genome when the animal's magnetic sense is disrupted.

Further, by knocking out certain genes associated with memory, the researchers could change a fly's sleep requirements.

In the current study, the researchers used infradian cyclic locomotor activity in the mutant mice as a proxy for mood - associated changes, and examined their molecular basis in the brain by conducting prediction analyses of the gene expression data.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

However, hypoxia - associated genes, Flt - 1 and EPOR, showed no significant changes in the current study.

There are lots of things, including exercise, that influence the activity of our genes and a big part of what we're trying to figure out is which gene changes are associated with promoting health.

In a study of 45 female monkeys, researchers observed that changes in social status affected genes that associated with stress and inflammation.

These included genes associated primarily with the vascular changes resulting from oxygen deprivation; namely (a) VEGF and its receptors Flk - 1 and Flt - 1 [17,56]; and (b) erythropoietin (EPO) and its receptor (EPOR)[16].

• CpG methylation status quantification PyroMark ID provides highly reproducible quantification of methylation frequencies in individual consecutive CpG sites, enabling accurate measurement of even small changes in methylation levels that are associated with deregulation of gene expression and tumorigenesis.

We use extensive genomic and gene - expression profiling techniques to identify molecules and molecular pathways that mediate the dynamic changes observed in vitro, and which are associated with different clinical outcomes in melanoma patients.

While there are noticeable changes in gene expression associated with PMI, we nonetheless found that the characteristic transcriptional signature of tissues remains largely intact through the PMI intervals considered here.

«The IL - 28B first came to the attention of virologists when it was shown that polymorphisms, small genetic changes, in this gene were associated with different hepatitis C virus treatment outcomes.

These proteins, called transcription factors, work by changing which genes are expressed in the cell, turning off genes associated with skin cells and turning on genes associated with stem cells.

Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.

Biologists often view cancer primarily as a genetic program gone wrong, with mutations and epigenetic changes producing cells that don't behave the way they should: Genes associated with cell division and growth may be turned up, and genes for programmed cell death may be turned Genes associated with cell division and growth may be turned up, and genes for programmed cell death may be turned genes for programmed cell death may be turned down.

The plates contained genes associated with proliferation and apoptosis, to confirm our in vitro findings that no changes occurred, as well as genes known to identify / enrich for CSC and those involved in CSC signaling.

«We saw hundreds of changes in genes in cancer cells that had not been identified before, and for each of these, HHMI research associate Alberto Bardelli had to perform comparisons with the normal tissues of the same patient, to see if the mutation was specific to the cancer,» he said.

In a study of umbilical cord blood from New York City children, researchers found a change in a gene called ACSL3 that is associated with prenatal exposure to chemical pollutants called polycyclic aromatic hydrocarbons (PAHs), which are byproducts of incomplete combustion from carbon - containing fuels, resulting in high levels in heavy - traffic areas.

The altered microbiota was associated with changes in colonic short - chain fatty acid (SCFA) concentrations, colonic - tissue gene expression (Gsta2 and Ela1), and host physiology (serum metabolite profiles and colonic goblet cell numbers).

«Our study shows the positive effects of exercise, because the epigenetic pattern of genes that affect fat storage in the body changes», says Charlotte Ling, Associate Professor at Lund University Diabetes Center.

In contrast with the changes in cell signaling, muscle mRNA responses of selected genes associated with muscle proteolysis and catabolism were largely unchanged between treatments.