The researchers found that the plasmalemma vesicle -
associated protein (PLVAP), often used as a marker for blood vessels, is expressed in lymph nodes not only in the blood vessels but also in the
lymphatic vessels that transport
tissue fluids.
Masters et al. discuss the often overlooked contribution of the stromal microenvironment as an extrinsic factor to immunosenescence and inflammation.12 Accumulation of senescent stromal cells which demonstrate the senescent
associated secretory phenotype (SAPS), may alter
tissue structure and function, and increase local inflammation.13 The impact of altered lymphoid stromal microenvironment may be widespread and include altered haematopoiesis, reduced
lymphatic flow and disrupted secondary lymphoid organisation, which consequently will alter antigen transportation and presentation to T cells.12