Sentences with phrase «associated macrophage»

Our primary aim is to identify subgroups of rNB patients who have potentially targetable genetic (ALK, MAPK pathway, Metabolic - related genes) and / or immunologic (tumor - associated macrophage infiltration and / or programmed death ligand [PD - L1] expression) biomarkers in rNB.

Cancer biologists give the name tumor - associated macrophages to these mutineers that congregate in and around the tumor.

However, when these myeloid cells migrate to tumor sites, they can differentiate to tumor associated macrophages (TAMs), which can in turn stimulate the formation of blood vessels in tumors and promote enhanced tumor cell invasion and motility.

But often tumors hijack them and convert them into what are known as «tumor - associated macrophages,» or TAMs for short.

Intermittent Hypoxia - induced Changes in Tumor - associated Macrophages and Tumor Malignancy in a Mouse Model of Sleep Apnea.

This subtype, named by the authors «senescence - associated macrophages» or SAMs, share some biomarkers of senescent cells by expressing p16 (Ink4a) gene and an enzyme beta - galactosidase.

In the presentation, Dr. Gudkov discusses findings from a study published earlier this month in the journal Aging, which identified a subset of immune cells, which the authors called senescence - associated macrophages (SAMs).

In the tumor microenvironment, galectin 3 is produced and secreted by tumor cells, tumor - associated macrophages, and exhausted T cells.

Not exact matches

«We hope that interventions to decrease macrophage activation early in HIV infection will decrease associated bone loss, which has become a major adverse side effect of HIV infection and its treatment,» Aldrovandi said.

In the bone, macrophages take the form of osteoclasts — the cells responsible for the resorptive processes associated with continuous bone remodeling.

This visual abstract represents the findings of Thevaranjan et al. who, using young and old germ - free and conventional mice, demonstrate that age - related microbiota changes drive intestinal permeability, age - associated inflammation, and decreased macrophage function.

This latest study aimed to identify urinary M2 macrophage - associated markers, by performing multiplex urinalysis in individuals prone to developing calcium oxalate kidney stones.

They show that highly purified NS1 acts as a pathogen - associated molecular pattern (PAMP) that activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) in culture via TLR4, resulting in release of inflammatory cytokines — an effect that was blocked by either a TLR4 antagonist or an anti-TLR4 antibody.

The scatterplot data suggest that macrophage accumulation in the subcutaneous depot may plateau at high degrees of adiposity, or that abnormalities associated with leptin deficiency may cause decreased macrophage accumulation specifically in the subcutaneous depot (Figure 3d).

The strong relationship between adipose tissue macrophage content and indicators of adiposity provides a mechanism for the increased adipose tissue production of proinflammatory molecules and acute - phase proteins associated with obesity.

To determine whether adipose tissue macrophages express any molecules implicated in obesity - associated complications, we isolated three cell populations from the parametrial adipose tissue of three obese B6.V Lepob / ob mice: (a) an adipocyte - enriched population, (b) a stromal vascular macrophage F4 / 80 + population, and (c) an F4 / 80 — stromal vascular population.

Jäger E, Ringhoffer M, Dienes HP, Arand M, Karbach J, Jäger D, Ilsemann C, Hagedorn M, Oesch F, Knuth A. Granulocyte - macrophage - colony - stimulating factor enhances immune responses to melanoma - associated peptides in vivo.

Evidence suggests that the resolution of infection and thus inflammation is prolonged due to reduced clearance of apoptotic cells and debris by macrophages.11 These age - associated alterations in innate immunity may contribute to increased systemic inflammation termed «inflamm - ageing» observed in aged tissues.10

Hematopoietic malignancies were diagnosed using the following markers: for B - and T - lymphocyte detection, rat antimouse CD45R / B220 mAb (Southern Biotechnology Associates, Birmingham, AL; dilution 1:100); for T - lymphocyte detection, rabbit antihuman CD3 polyclonal antibody (Dako, Glostrup, Denmark; 1:100); and for monocyte / macrophage detection, rat antimouse F4 / 80 mAb (BMA Biomedicals AG, Augst, Switzerland; 1:20) and rat antimouse CD11b mAb (Chemicon International, Temecula, CA; 1:20).

Moreover, there are yet other cell types — such as visceral adipose tissue macrophages and cytotoxic CD8 + T - cells — in which the age - related supernumerary accumulation of dysfunctional and apoptosis - resistant cells appears to play a highly deleterious role on tissue function, but where the cells are not «senescent» cells in the classical sense of p16Ink4a expression and the senescence - associated secretory profile observed in senescent fibroblasts.

Brandon Hall et al (2017) p16 (Ink4a) and senescence - associated β - galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli (http://www.aging-us.com/article/101268/text) or (https://doi.org/10.18632/aging.101268)

Results: Scientists at Pacific Northwest National Laboratory (PNNL) have reported the first systematic investigation using global proteomics to identify changes in the abundance of bacterial proteins associated with macrophage colonization and a new protein that helps the bacterium to survive inside macrophages.

B. Hall et al (2016) Aging of mice is associated with p16 (Ink4a)- and β - galactosidase - positive macrophage accumulation that can be induced in young mice by senescent cells (http://www.aging-us.com/article/100991)

Abbreviations: ASC, apoptosis - associated speck - like protein containing a caspase - recruitment domain; ATM, adipose - tissue - resident macrophage; BAT, brown adipose tissue; CCR2, CC chemokine receptor 2; CHOP, C / EBP (CCAAT / enhancer - binding protein)- homologous protein; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; GPCR, G - protein - coupled receptor; HIF, hypoxia - inducible factor; IFNγ, interferon γ; IKK, inhibitor of nuclear factor κB kinase; IL, interleukin; IRS - 1, insulin receptor substrate - 1; JNK, c - Jun N - terminal kinase; LDL, low - density lipoprotein; Ldlr, LDL receptor; LXR, liver X receptor; MCP - 1, monocyte chemoattractant protein 1; miRNA, microRNA; mTOR, mammalian target of rapamycin; NAFLD, non-alcoholic fatty liver disease; NF - κB, nuclear factor κB; NLRP3, NLR (nucleotide - binding - domain - and leucine - rich - repeat - containing) family, pyrin - domain - containing 3; oxLDL, oxidized LDL; PKR, double - stranded RNA - dependent protein kinase; PPAR, peroxisome - proliferator - activated receptor; STAT6, signal transducer and activator of transcription 6; SVF, stromal vascular fraction; TLR, Toll - like receptor; TNFα, tumour necrosis factor α; UPR, unfolded protein response; WAT, white adipose tissue

Certain metabolites, such as fatty acids, ceramides and cholesterol crystals, elicit inflammatory responses through pathogen - sensing signalling pathways, implicating a maladaptation of macrophages and the innate immune system to elevated metabolic stress associated with overnutrition in modern societies.

Importantly, the blebs only become bound to cells that are associated with the macrophages at the time of isolation since co-preparation of LN cells from congenically distinct animals did not lead to cross acquisition of macrophage - derived blebs by innate - like lymphocytes from the different LNs (Gray et al., 2012).

It is often associated with the presence of macrophages and lymphocytes, fibrosis, vascular proliferation, and tissue destruction.

He says that when the yogurt arrives in the gut where there are the highest number of microphages in the GALT (gut associated lymph tissue), the immune system of the gastrointestinal tract, it activates the macrophages.

There is an increase in nondegenerate neutrophilsm, small to intermediate mature lymphocytes, rare macrophages, rare plasma cells, and rare lymphoblasts seen intimately associated with hepatocellular clusters.