Sentences with phrase «associated phosphatidylinositol»
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate - 1 (IRS - 1)- associated phosphatidylinositol 3 - kinase activity in muscle.
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Moreover, our previous study found that regular use of aspirin after diagnosis was associated with longer survival among the 15 % to 30 % of patients with colorectal cancer and with a mutation in phosphatidylinositol -4,5-bisphosphate 3 - kinase, catalytic subunit alpha (PIK3CA [NCBI Entrez Gene 5290]-RRB-, one of the PI3K family genes.30 Markedly improved survival associated with aspirin according to PIK3CA status was also found in an analysis within a separate clinical trial cohort.31 Further investigations for the joint effect of these genes would be helpful to better understand the underlying molecular mechanisms of aspirin, NSAIDs, and colorectal cancer.
The membrane associated adaptor ankyrin - B (AnkB) promotes fast axonal transport and elongation by coupling dynactin to multiple organelles through binding to phosphatidylinositol 3 - phosphate lipids in these cargos.
After examining over 300 dogs, Dr. Stern identified a mutation in the phosphatidylinositol - binding clathrin assembly protein (PICALM), a protein that is found in the canine heart, that is associated with the development of SAS in Newfoundland dogs and determined that this particular mutation is passed down to their puppies.