Sentences with phrase «association studies into»

The results of this study suggest that high - resolution fine - mapping in large samples can convert many discoveries from genome - wide association studies into statistically convincing causal variants, providing a powerful substrate for experimental elucidation of disease mechanisms.

Not exact matches

Contextual procedures that in the 1960s had promoted the opposite view fell into disuse.24 In part the shift reflected the increasing difficulty of the mainline churches in sustaining contextually oriented agencies and studies whose intention was to revise the church's basic form of association.

Sources tell Press Association Sport that a major study into whether footballers are at greater risk of degenerative brain disease is set for launch in the next few weeks with the appointment of a research group to undertake the most comprehensive study of its kind, jointly commissioned by the Football Association and Professional Footballers» Association.

At least one study limits the association to babies co-sleeping with someone other than parents, but grandparents fall into that category.

Infants who are breastfed for 7 to 9 months may have a small but significant gain in intelligence that lasts at least into early adulthood, according to a study published Wednesday in the Journal of the American Medical Association.

Second, because almost all of the studies examining this association were observational, there was a possibility of confounding, particularly by familial and socioeconomic circumstances, which could not be taken into account with the published data available.

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But studies presented November 17 during the American Heart Association Scientific Sessions call into question doctors» recommendations on induced hypothermia and cast doubt on the necessity of a quick cooldown.

In 1969, when the AAAS Board first suggested creating a special committee to draw up a statement concerning the freedom and responsibilities of scientists, association leaders, along with a number of other scientific societies, were looking into allegations that the Public Health Service was rejecting the appointment of scientists to study sections based upon the candidates» political views and affiliations.

Yancy, chief of cardiology at Northwestern University's medical school and a former president of the American Heart Association, is leading a new NIH - sponsored study into how the agency might improve the pool of talent going into biomedical research.

Furthermore, the report accuses the British Homeopathic Association (BHA), which had submitted evidence to the panel, of cherry - picking, and even, in one case actively misrepresenting, research into the treatment (a famous study that concluded its findings were «compatible with the notion that the clinical effects of homeopathy are placebo effects» was cited by the BHA as evidence of the treatment's efficacy.)

A new flu vaccine sprayed into the nose may be just as good as a shot in the arm, according to a study in this week's Journal of the American Medical Association.

Members of the public in counties with higher median household incomes are more likely to step into action to perform cardiopulmonary resuscitation, or CPR, when they witness someone have a cardiac arrest, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania, which was presented today at the American Heart Association's Resuscitation Science Symposium 2014.

Childhood bullying may lead to long - lasting health consequences, impacting psychosocial risk factors for cardiovascular health well into adulthood, according to a study published in Psychological Science, a journal of the Association for Psychological Science.

But as he was digging into the study, his source of funding came under attack from the National Rifle Association (NRA), a powerful lobbying group based in Fairfax, Va., that supports gun ownership.

In a study published today in the journal PLOS ONE, they found a «statistically significant association» between higher vitamin D levels and lower non-HDL cholesterol, even after taking into account such things as Body Mass Index, consumption of cow's milk and levels pf physical activity.

The Tokyo - based Radiation Effects Association already has an ongoing study of the health of Japanese nuclear - power workers, and new dosimetric data for Fukushima workers will be merged into that study.

Under the new plan, CDC, in a collaboration with the Association of Public Health Laboratories (an affiliation of U.S. state and local health labs), will put all sequence information on the several hundred different flu isolates it studies every year into publicly accessible databases such as GenBank as soon as possible.

Drug - resistant bacteria that usually attack only hospital patients may now have jumped into broader circulation in the general population, according to a study in tomorrow's Journal of the American Medical Association.

In a study published last year in the Journal of the American Medical Association, researchers described a poignant example of this dynamic after they followed nearly 5,000 low - income families who moved out of public housing and into better neighborhoods.

«No link found between subcortical brain volumes, genetic risk for schizophrenia: Proof - of - concept study provides roadmap for future research into possible associations between brain volume measures, known genetic risk factors.»

«Results from our observational study in young adults with normal kidney function may not translate into a clinically meaningful difference and may be insufficient to inform decision - making concerning marijuana use; however, it is possible that the association between marijuana use and kidney function could be different in other populations such as older adults or patients with kidney disease, so additional research is needed,» said Dr. Ishida.

Studies have shown that the NMDA receptor appears to operate in brain cells as a «coincidence detector»: It springs into action when two neurons fire at the same time, creating an association between them, and has therefore long been suspected to play a role in learning.

«To our knowledge, this is the first study to examine the association of genomics with opioid withdrawal in infants and may provide insight into the mechanisms underlying NAS.

The Compendium includes case studies from medical groups, independent practice associations, academic practices, and integrated delivery systems that have incorporated the management of chronic obstructive pulmonary disease (COPD) into their chronic care models.

Stanton A. Glantz, Ph.D., of the University of California, San Francisco, and coauthors examined internal documents from the Sugar Research Foundation (SRF), which later evolved into the Sugar Association, historical reports and other material to create a chronological case study.

Also, we would like to study what percentage of the association between respiratory tract infections and asthma can be explained by changes in lung function, and whether the associations change when we take early - life wheezing into account,» she will conclude.

In a study published today in the journal PLOS ONE, they found a «statistically significant association» between higher vitamin D levels and lower non-HDL cholesterol, even after taking into account such things as Body Mass Index, consumption of cow's milk and levels of physical activity.

The project described in this proposal will help us to extend the findings from other genetics research, including GWAS (genome - wide association studies) and in vitro studies, into an in vivo investigation using mouse models in order to establish BIN1 as a potential new candidate in AD pathophysiology.

A decade into the era of well powered and reproducible genome wide association studies, one thing is clear: many complex diseases are extremely polygenic, with thousands or perhaps tens of thousands of segregating variants contributing to variation in risk among individuals.

Genome - wide association scans with high - throughput metabolic profiling are powerful tools to study into how genetic variation influences metabolism and complex disease.

A recent study by the British Geological Survey, in association with researchers at the University of Leicester, has delved into the bone and tooth chemistry of King Richard III and uncovered fascinating new details about the life and diet of Britain's last Plantagenet king.

CLU is a confirmed AD gene from genome - wide association study, and encodes apolipoprotein J, which has been shown to chaperone re-entry of Aβ into the brain following export of the peptide from the brain into the blood.49 Interestingly, genes encoding two peptidases known to degrade Aβ were also decreased in expression in blood pre — post intervention as part of the vacation effect: MME (P = 0.00019) and ECE1 (P = 0.0037).

By carrying out a genome - wide association study that took into account whether or not a person has faced a major adversity in their life, the scientists were able to identify contributing molecular mechanisms that not previously been associated with depression.

EML4 was novel, but when the authors imputed sequencing variants into a much larger sample collection (44,414 individuals from 17 other studies), the association didn't hold up.

Secondly, methods are available for estimating dose - response associations for meta - analyses that take into account that relative risk estimates across smoking categories are expected to be correlated within a study because they use the same reference group (never smokers in our case).

In a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissue.

First publication of genome - wide association study leveraging deCODE's population approach; Finding to be integrated into deCODE's DNA - based diagnostics program A team of deCODE scientists, along with academic colleagues from the United States, Iceland, Spain and the...

131/5: 00 Phenome - wide association study provides biologic insights into the etiology of age - related macular degeneration.

We will provide a brief overview of results ranging from common, to low - and rare - frequency variant - trait association studies, studies leveraging the diversity across populations, and studies harnessing the power of genetic and genomic approaches to gain insights into the biological underpinnings of these traits.

We then imputed from these sequences into new and existing genome - wide association study cohorts and tested for association at ∼ 12 million variants in a total of 16,432 cases and 18,843 controls.

Conclusions / significance: This study is one of the first genome - wide association analyses in a parasitic nematode, and provides insight into the genomics of ivermectin response and population structure of O. volvulus.

Mapping hundreds of genetic variants through genome wide association studies provided an opportunity to gain insights into the pathobiology of immune mediated diseases.

«Most of the past research into the harmful effects of low vitamin D has focused on the elderly, but relatively few studies have examined this association in the elite athlete,» Rebolledo said in a Scripps news release.

«It's not clear if [Chan's study] falls into the same trap as previous studies that found similar associations, but didn't stand up to rigorous scrutiny,» Swaminath said.

Another 2011 study confirmed this observation; not only was lower sodium excretion associated with higher CVD mortality, but baseline sodium excretion did not predict the incidence of hypertension, and any associations between systolic pressure and sodium excretion did not translate into less morbidity or improved survival.

Several trials have demonstrated that the cardiomyocytes of rodents maintained on IER become more resilient to ischaemic injury induced by occlusion of the left coronary artery 18, 21, 29, which translated into improved long - term survival following such injury in one study.21 In addition, within these studies, associations have been found between the cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular health.

A study published by the American Psychological Association found when children are victims of obscene telephone calls, there was little difference in the amount of damage caused from having a few curse words thrown into the conversation and not having any at all.

Furthermore, positive associations between TSH and LDL as well as total cholesterol levels have been found in cross-sectional studies in euthyroid healthy subjects, and the strength of these associations seems to depend on an individual's insulin sensitivity.We therefore hypothesize that the KD has diminished the production of T3 from T4, thereby reducing the number of LDL receptors and thus reducing LDL particle clearance which might be further impaired due to the missing stimulating effect of insulin on LDL uptake into cells.

His team takes various studies and observations, takes the associations and correlations they find, and turn them into subjects.