Some groundbreaking findings from this study appear in a recent paper in PLoS Genetics, «Genome - wide
Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers» (http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004922) From work performed in Dr Lindblad - Toh's lab, the investigators report that they have identified two loci that together contribute approximately 20 % of the risk of developing hemangiosarcoma and lymphoma in Goldens.
152/6: 15 Ancestry matched genome - wide
association study identifies variants associated with spontaneous preterm birth.
Genome - wide
association study identifies sequence variants on 6q21 associated with age at menarche.
Genome - wide
association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
Rafnar T European genome - wide
association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.
for article Genome - wide
association study identifies 74 loci associated with educational attainment.
Genome - wide
association study identifies a second prostate cancer susceptibility variant at 8q24.
Genome - wide
association study identifies a new melanoma susceptibility locus at 1q21.3.
The paper, «Genome - wide
association study identifies sequence variants on 6q21 associated with age at menarche,» is published in the online edition of Nature Genetics, at www.nature.com/ng, and will be published in an upcoming print edition of the journal.
Genome - wide
association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.
Genome - wide
association study identifies two novel Loci with sex - specific effects for type 2 diabetes mellitus and glycemic traits in a korean population
The study entitled «A multi-national Arab genome - wide
association study identifies new genetic associations for Rheumatoid Arthritis», has now been published in the prestigious medical journal Arthritis & Rheumatology; and was supported by grant from the Qatar National Research Fund, a member of Qatar Foundation.
Genome - wide
association study identifies shared risk loci common to two malignancies in golden retrievers.
«Face shape is in the genes: Genome - wide
association study identifies genetic variants that contribute to healthy facial traits.»
Recent genetic
association studies identified variants in a locus on chromosome 15 (specifically, in the adjacent genes HERC2 and OCA2) that are major determinants of eye color, but the trait is influenced by interaction among at least ten different genes.
Such work has become increasingly important given the expansion of genome - wide
association studies identifying genetic risk factors for common diseases and corresponding efforts to commercialize genetic testing using these markers.
A pan-genome-wide
association study identified prophage sequences as being associated with decreased carriage duration independent of serotype, potentially by disruption of the competence mechanism.
69/3: 00 Genome - wide
association studies identify RAB38 and HS6ST1 associated with albuminuria in diabetes.
Not exact matches
Nebraska's position was buttressed by various statements of the American Medical
Association, which had previously supported a federal version of the ban on partial «birth abortion, and which after expert
study had been unable to
identify any circumstance where partial «birth abortion was the only appropriate procedure.
To determine whether the presence and strength of the
associations between individual risk factors and severe PPH vary among women undergoing prelabor CD or intrapartum CD, stratified analyses are needed according to CD subtype.To
identify risk factors for severe PPH within 2 distinct CD populations, prelabor CD and intrapartum CD, we performed 2 case - control
studies.
Using a novel method, Whitehead Institute researchers have determined how a non-coding mutation
identified in genome - wide
association studies (GWAS) can contribute to sporadic Parkinson's disease (PD).
Meta - analyses of genome - wide
association studies conducted in these ethnically - diverse populations
identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.
Studies have
identified an
association between maternal infection and inflammation and preterm birth, in addition to the development of cerebral palsy and neuropsychiatric conditions such as schizophrenia and autism.
A Mayo Clinic
study has
identified a familial
association in spontaneous coronary artery dissection, a type of heart attack that most commonly affects younger women, suggesting a genetic predisposition to the condition, researchers say.
«This
study identified a potential
association between probiotics and lower respiratory infections,» said Azad.
This was puzzling because that locus was not consistent with SLE loci
identified by other genome - wide
association studies.
«Our
study strengthens the clinical
association between intestinal permeability and NASH, although we were unable to
identify a mechanism,» said lead
study author Jay Luther, MD, from Massachusetts General Hospital.
Although the team controlled for these factors in the analyses, the possibility of a partial confounding effect on the
associations identified in the
study can not be ruled out.
Genome - wide
association studies are notoriously weak in
identifying variants that strongly determine our health.
While several
studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide
association (GWA) analysis, which scans an individual's whole genome to
identify chromosomal regions containing variants that are associated with the disease traits that are being
studied.
Pepino cautioned that the
study only
identified associations between smoking and taste rather than definitive reasons why obese smokers were less likely to detect fat and sweetness.
A 2001 Kansas State University
study identified a type of lecithin called phosphatidylcholine in eggs that interferes with cholesterol absorption, which may explain why many
studies have found no
association between egg intake and blood cholesterol level.
«Important
associations between genetics, sleep behavior
identified by
study.»
«Our approach is likely to «revive» genome - wide
association studies as a strategy to
identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»
A genome - wide
association study (GWAS) of 1570 Africans
identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.
«Given the similarities in the molecules and the mechanisms involved in limb development in vertebrates and invertebrates, the fly is a very useful genetic model in which to
identify new genes that potentially participate in limb development in vertebrates and their possible
association with congenital diseases,» says Ana Ferreira, who has participated in the
study.
Clinical features of major depressive disorder (MDD) may help
identify specific subgroups of depressed patients based on
associations with genetic risk for major psychiatric disorders, reports a
study in Biological Psychiatry.
Previous
studies have
identified a link between creativity and psychiatric disorders such as bipolar disorder, but it has remained unclear whether this
association is due to common genes.
«These
studies do not necessarily provide final evidence,» said Garland, «but they have been helpful in the past in
identifying associations that have helped minimize cancer risk.»
In 2013, a genome - wide
association study of AD in more than 5,500 African Americans
identified two genetic risk factors for AD.
Using a genome - wide
association study (GWAS) that includes 1600 individuals living in Tanzania, Botswana, or Ethiopia, the authors
identified regions of the genome that contribute to skin color variation and carried out a series of analyses to pinpoint the responsible genes.
«In fact,
studies that formed the empirical base for the American Psychiatric
Association guidelines for depression treatment included 3,860 participants, with only 27
identified as African American and none as being of Latina descent,» the authors write.
To investigate the
association of smoking, before and after diagnosis, with all - cause and colorectal cancer - specific mortality among colorectal cancer survivors, researchers led by Dr. Peter Campbell
identified 2,548 people newly diagnosed with invasive, non-metastatic colorectal cancer from among 184,000 adults in the American Cancer Society's Cancer Prevention
Study II.
Nestadt says the genome - wide
association study findings of a PTRPD - OCD link add to evidence that the genetic region they
identified is important.
A total of 21
studies were
identified assessing the
association between pesticides and diabetes, covering 66,714 individuals (5,066 cases / 61,648 controls).
Although this
study can not
identify the exact nature of the
association between soft drink consumption and problem behaviors, limiting or eliminating a child's soft drink consumption may reduce behavioral problems.
A
study published in the 27 September edition of JAMA, the Journal of the American Medical
Association, examined how bias impacts the peer review process of medical journals by comparing what happens when
study authors are
identified for reviews, known as a single - blind review, and when the identity of
study authors is kept from reviewers, known as double - blind reviews.
The prospective cohort
study met both its primary endpoints: to determine the
association between troponin T levels measured by a high - sensitivity troponin T assay and the risk of death within a month of non-cardiac surgery, and to
identify diagnostic criteria for myocardial injury after non-cardiac surgery that defines whether or not serious injury to the heart has occurred.
Corresponding author, Dr Seth Weinberg says «Our analysis
identified several genetic
associations with facial features not previously described in earlier genome - wide
studies.
To
identify these variants, scientists performed a genome - wide
association study.