Sentences with phrase «asthma in genetic studies»

A variant in the gene for this receptor previously had been linked to asthma in genetic studies, but the potential role of the receptor, called CDHR3, in asthma was unknown.

Not exact matches

Meta - analyses of genome - wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.

A major finding of this study is that the genetic loci associated with asthma are enriched in epigenetic marks characterizing gene enhancers.

Among the Dunedin study participants who developed asthma in childhood, those with higher genetic risk scores were also more likely to suffer with persistent asthma into adulthood.

In the new work, researchers looked at genetic and health data on more than 100,000 individuals from previous large studies to determine whether genetic alterations that are associated with vitamin D levels predispose people to asthma, dermatitis, or high IgE levels.

In previous genetic studies, this variant had been linked to a greater risk of wheezing illnesses and asthma hospitalizations during childhood.

In a new project that began this month, Drs. Anuradha Ray and Wenzel were recently awarded a five - year, $ 8 million grant from the National Institute of Allergy and Infectious Diseases (NIAID), also part of the National Institutes of Health (NIH), to continue studying the immune response and genetic roots of severe asthma in 120 patients and in animal modelIn a new project that began this month, Drs. Anuradha Ray and Wenzel were recently awarded a five - year, $ 8 million grant from the National Institute of Allergy and Infectious Diseases (NIAID), also part of the National Institutes of Health (NIH), to continue studying the immune response and genetic roots of severe asthma in 120 patients and in animal modelin 120 patients and in animal modelin animal models.

Previous genome - wide association studies (GWAS) by the group have identified new genetic risk factors for the higher rates of asthma and poor response to bronchodilator medications seen in these minority populations — in many cases different from risk factors seen in prior studies conducted in European Americans.

Native American ancestry is associated with a lower asthma risk, but African ancestry is associated with a higher risk, according to the largest - ever study of how genetic variation influences asthma risk in Latinos, in whom both African and Native American ancestry is common.

Although differences in the environments in which people live often are suspected when asthma risks among populations differ, the new findings illustrate the importance of also considering genetic differences among ethnic groups in diagnosing and treating disease, said Esteban Burchard, MD, professor of bioengineering for the UCSF School of Pharmacy and the senior scientist for the study.

In the new study, the lab has conducted the first large - scale whole genome sequencing study of asthma drug response in African Americans and Latino children in an effort to pin down the genetic factors contributing to reduced albuterol response more precisely than possible in previous association studieIn the new study, the lab has conducted the first large - scale whole genome sequencing study of asthma drug response in African Americans and Latino children in an effort to pin down the genetic factors contributing to reduced albuterol response more precisely than possible in previous association studiein African Americans and Latino children in an effort to pin down the genetic factors contributing to reduced albuterol response more precisely than possible in previous association studiein an effort to pin down the genetic factors contributing to reduced albuterol response more precisely than possible in previous association studiein previous association studies.

For many human diseases, large - scale genomic studies have identified common genetic variants that occur more frequently in people with cardiovascular, autoimmune, inflammatory and infectious diseases, diabetes and asthma than in those without these diseases.