Asymmetric division refers to a process in which a cell divides into two daughter cells that are not identical to each other. One of the daughter cells retains the characteristics and specialized functions of the parent cell, while the other becomes a different type of cell altogether. This type of division is important for generating diversity and maintaining specific cell types within the body.
Full definition
Accordingly, our data suggests that the failure of regenerative myogenesis to keep pace with disease progression in DMD is not due to muscle stem cell exhaustion, but rather is due to a cell - autonomous deficiency
in asymmetric division.
Ueda's group found that in the zygote, the factors derived from the parents cooperate with each other to bring
about asymmetric division of the zygote and appropriate development of the embryo.
But in a process
called asymmetric division, a cell divides into two daughters that are not identical — a skin stem cell divides into another skin stem cell and a regular skin cell, for example.
After a certain period, some of these stem cells switch to producing neurons, a stage known
as asymmetric division.
Importantly, this results in an abnormal increase in centrosome number, a 10-fold reduction in the numbers of satellite stem cells
undergoing asymmetric divisions, and a marked decrease in the generation of myogenin - expressing progenitors.
Furthermore, cells in which MELK had been depleted
displayed asymmetric division (Figure 6G), characterized by an unequal allocation of cell mass into daughter cells.
In a zygote absent of SSP or HDG11 / 12, the group artificially synthesized the WOX8 protein, which led to
asymmetric division of the zygote.
«Plant's parent genes cooperate in shaping their child: Discovery of parental factors that lead to
asymmetric division of the zygote.»
Ueda's group also discovered HOMEODOMAIN GLABROUS11 (HDG11) and HDG12, the factors derived from the egg cells, which are responsible for controlling
the asymmetric division of the zygote and development of the embryo.
HDG11 / 12 are not expressed in the sperm cell, and the HDG11 / 12 derived from the egg cell lead to
asymmetric division of the zygote.
The group previously reported that WRKY2 acts upon the WUSCHEL (WUS) HOMEOBOX8 (WOX8) gene to synthesize the WOX8 protein, which leads to
asymmetric division of the zygote.
«It is
an asymmetric division,» he continues.
Ueda and Kimata used fluorescent markers of MTs and F - actin to see how they change before and after fertilization, and how the two fibers play a role in the polarization and
asymmetric division of the zygote.
Microenvironmental perturbation,
asymmetric division, and transcriptional regulation are considered in a cross-cutting mechanism - centred work package.
16 - cell stage doublet resulting from
the asymmetric division of an isolated 8 - cell stage blastomere.