Sentences with phrase «at a higher dose in»

Because AML is difficult to treat, standard treatment commonly involves multiple chemotherapy medicines that are given at a higher dose in order to kill the cancer cells.

DNA interstrand crosslinks (ICLs) are highly toxic DNA lesions that can form endogenously but are also induced at high doses in cancer chemotherapy.

Young, growing animals due to potential for cartilage abnormalities Use with caution in animals with liver or kidney conditions, or those suffering dehydration Should not be used at high doses in cats (may cause blindness) Breeding, pregnant or nursing animals Pets who have a history of seizures or other central nervous system disorders Pets known to have had an allergic reaction to other quinolones and / or sulfonamides Directions:

Side effects are rare for ivermectin given at heartworm preventive doses Considered to be safe in pregnant and nursing animals Problems may arise at high doses in some dogs, especially Collies, Australian Shepherds, Old English Sheepdogs, Shelties and any of these crossbreed dogs.

Not exact matches

Caffeine, which is also found in coffee, can be deadly at high doses — but that doesn't mean all caffeine is bad.

In the blog post «Some gold bulls need a dose of realism ``, I noted that relative to the Goldman Sachs Spot Commodity Index (GNX) the gold price was at an all - time high and about 30 % above its 2011 peak.

Another good way to get a high dose of protein in at breakfast is to supplement your meal with a protein shake.

These bars are high in fibre at 7g per bar, provide a little dose protein, natural sweetness from the dates for quick releasing energy, and a nice boost of antioxidants!

Liverpool's high pressing game will come to not in this big PL game because the Gunners have more than prepared themselves to negate whatever the Reds have on offer against them in the game by making themselves bigger in the game than the Reds have imagined by inflicting on them a heavy punishment on the field of play during the playing of the match to make them pay for the sin they've committed against Arsenal by giving them a dose of their own medicine for having the audacity to come to the Emirates Stadium and took away all the 3 points that were at stake in an opening day PL game without at least leave a point for Arsenal to collect in the match..

GU Energy Gel provides a dose of 100 calories to deliver high - quality, easily - digested and long - lasting energy for athletes in every sport and at all levels.

The highest amount of this medication that may be present in your breast milk should be at around five hours after you take a dose, but since you will need to be taking frequent doses throughout the time you are on it, you should assume that the amount present in your milk remains more or less the same.

I believe in PROTON PUMP INHIBITORS at fairly «high» doses.

It's even more repulsive in light of a recent study by Dr. Andrew Chang of Albany Medical Center, published in the Journal of the American Medical Association, showing opioids were no more effective at reducing pain for patients with broken limbs than a high - dose combination of the over-the-counter, non-addictive painkillers ibuprofen and acetaminophen.

«And at the higher dose, we saw a rescue of the neural stem cell pool in aged mice.»

During the study, thirty hours following a high - dose intravenous infusion of EP055 in male rhesus macaques, O'Rand and researchers in the Oregon National Primate Research Center at OHSU in Portland, Oregon, found no indication of normal sperm motility.

«The median percentage reduction in seizure frequency was more than 29 percent for patients on a low - dose regimen of everolimus and nearly 40 percent for patients with high - dose regimen to the drug,» says David Franz, MD, founding director of the TSC Clinic at Cincinnati Children's Hospital Medical Center and the study's senior author.

To please regulators that would ultimately greenlight clinical trials, Moderna will have to show its drug is still safe at a dose 10 times higher than what's needed to treat the disease — something the new paper doesn't demonstrate, says geneticist Michael Heartlein, chief technical officer at the competing mRNA company Translate Bio in Cambridge.

At low doses of cocaine, the GAPDH in the nucleus will stimulate the neuron, but at higher doses it activates the cell's self - destruct pathwaAt low doses of cocaine, the GAPDH in the nucleus will stimulate the neuron, but at higher doses it activates the cell's self - destruct pathwaat higher doses it activates the cell's self - destruct pathway.

«For example, in Alberta and Ontario, oxycodone is the drug most commonly prescribed at high doses, while in British Columbia, it's morphine.»

«Provinces not only differed in their prevalence of high - dose opioid prescribing, but each province also appears to favour different opioids,» said Gomes, who is also a scientist at ICES.

My sense is when you get the dose too high, you are flooding the system, and it's binding to some of the receptors where you don't want it to bind,» says Linmarie Sikich, director of the Adolescent and School - Age Psychiatric Intervention Research Program (ASPIRE) at the University of North Carolina at Chapel Hill, who was not involved in the research.

At much higher doses, benzodiazepines treat epilepsy and anxiety in human patients now, including those with autism.

Researchers at St. Michael's Hospital and the Institute for Clinical Evaluative Sciences (ICES) found that rates of high - dose opioid dispensing across Canada increased from 781 units per 1,000 people in 2006 to 961 units per 1,000 people in 2011.

«With some of the technological advances in radiation treatments that have occurred in the last five to 10 years, we're beginning to re-look at the issue and ask — can we target the radiation precisely enough and with a high enough dose to knock the cancer back?»

Additionally, I predict that at the completion of our study, despite the higher doses given per treatment in the experimental accelerated, hypofractionated RT arm, there will be no increased toxicity with this regimen.

Conventional, high - dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors» recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered.

One moderate sacral insufficiency fracture occurred in one patient at the highest tested dose of 20 mg / kg every three weeks after 6 cycles.

Based on the results of a pilot study at MGH that evaluated doses as high as 40 grams, participants in the current study received doses of up to 30 grams daily.

His group found evidence in 91 patients tapering off opioids that those whose doses were higher at the start, forcing them to make greater reductions over the 3 - week program, had worse measures of heat pain hyperalgesia.

Colvin says she already sees strong evidence of hyperalgesia in high - dose opioid users at the clinic where she works.

At a 0.2 - millimolar sucralose dose similar to the concentration found in the blood of people with high consumption of low - calorie sweeteners — equal to four cans of diet soda per day — the researchers said they observed increased expression of genes that are markers of fat production and inflammation.

Threats of explosions and dangerously high radiation doses are just some of the risks facing workers trying to avert complete meltdowns at multiple reactors in Japan

The effectiveness of leptin at battling diabetes in these animals may have been due to the high doses given, says Laura McCabe, a physiologist at Michigan State University in East Lansing.

The findings build on earlier research suggesting that the high - dose vaccine may be better at preventing influenza virus infections and other flu - related outcomes in seniors, including office visits and hospitalizations, compared to the standard - dose vaccine.

Despite the availability of many excellent antibiotics, bacteria are developing resistance to those most commonly used, forcing physicians to give higher doses or fall back to «last line of defense» drugs, said co-senior author Dr. Erdal Toprak, Assistant Professor of Pharmacology and in the Cecil H. and Ida Green Comprehensive Center for Molecular, Computational, and Systems Biology and a Southwestern Medical Foundation Scholar in Biomedical Research at UT Southwestern.

In that way, the small intestine shields the liver from dangerously high doses of fructose, says Joshua Rabinowitz, a metabolism researcher at Princeton University.

During the 2012 - 2013 season, when H3N2 viruses were dominant, the high - dose flu vaccine was 36 percent more effective at preventing deaths in the Medicare beneficiaries studied, compared to the standard - dose vaccine.

For example, a study just out in The Lancet, funded by the U.S. Food and Drug Administration and focused on Medicare patients, found that the high - dose vaccine was 22 percent more effective at preventing flu - related hospital admissions.

Yesterday, at the annual American College of Rheumatology meeting in Atlanta, Ga., researchers announced the results of a double - blind, randomized trial in more than 600 patients: tasocitinib eased pain and inflammation in 65.7 percent of those who received the highest dose of the drug, whereas only 26.7 percent of those who received a placebo reported relief.

«In a bad flu season, high - dose flu vaccine appeared better at preventing deaths in seniors.&raquIn a bad flu season, high - dose flu vaccine appeared better at preventing deaths in seniors.&raquin seniors.»

Anaesthesiologist David Waisel at Harvard University is concerned Phillips may not be rendered sufficiently unconscious by the injected midazolam before the high dose of hydromorphone — which can cause soft tissue in the throat to collapse — takes effect.

Other Alzheimer's drugs are also in development and being tested at higher doses.

But at higher — albeit still modest — doses, it produced repetitive behaviors similar to the tooth - grinding and compulsive skin - picking seen in human meth and MDPV users.

In a pilot study that included children at high risk for type 1 diabetes, daily high - dose oral insulin, compared with placebo, resulted in an immune response to insulin without hypoglycemia, findings that support the need for a phase 3 trial to determine whether oral insulin can prevent islet autoimmunity and diabetes in high - risk children, according to a study in the April 21 issue of JAMA, a theme issue on child healtIn a pilot study that included children at high risk for type 1 diabetes, daily high - dose oral insulin, compared with placebo, resulted in an immune response to insulin without hypoglycemia, findings that support the need for a phase 3 trial to determine whether oral insulin can prevent islet autoimmunity and diabetes in high - risk children, according to a study in the April 21 issue of JAMA, a theme issue on child healtin an immune response to insulin without hypoglycemia, findings that support the need for a phase 3 trial to determine whether oral insulin can prevent islet autoimmunity and diabetes in high - risk children, according to a study in the April 21 issue of JAMA, a theme issue on child healtin high - risk children, according to a study in the April 21 issue of JAMA, a theme issue on child healtin the April 21 issue of JAMA, a theme issue on child health.

Levels detected in a short duration pulse at the plant itself have reached as high as 8,217 microSieverts per hour, or eight times the dose endured in a typical CT scan and four times the normal dose of background radiation in a year.

The World Health Organization is working to increase the percentage of infants who receive at least three doses of pertussis vaccine to 90 percent or higher, especially in developing countries.

«The advantage of being able to deliver methotrexate in this targeted way is to be able to gain the benefits from this key treatment of RA, while reducing the risk of adverse effects that are more frequent at high doses,» concluded Dr Macor.

Patients in the study were those at highest risk for developing chronic pain and persistent high - dose opioid use after major surgery.

Most are the same ingredients found in a typical multivitamin but at much higher doses.

The drug, daratumumab, proved generally safe in patients, even at the highest doses tested in the study.