Sentences with phrase «at a target site in»

Not exact matches

Mobile web games can be distributed to millions within the brand's target demographics through emerging mobile - web - game distribution channels, including popular mobile media sites, portals, messaging apps and carrier and mobile browser storefronts at a fraction of what it costs to drive installs in the app stores.

In our tests, the Gene Knockout Kit gave us greater than 80 percent knock - out rates for seven targets,» shares Shondra Miller, Ph.D., Director, Center for Advanced Genome Engineering at St. Jude Children's Research Hospital, on Synthego's web site.

Andrew of Vab Media, is a search engine optimization specialist that has demonstrated a clear ability to analyze, develop and implement targeted strategies aimed at improving a site's placement in organic search results.

Why this matters: Code governing control systems at industrial sites has already been the target of attacks, and US officials recently warned Russian hackers are probing for security holes in software controlling critical infrastructure like nuclear facilities and dams.

Gamification — understanding the sales cycle at MyCheck, and the focus in the mobile payment industry on features, we created an innovative «Feature Cart» for the site which dynamically increased site engagement and allowed targeted buyer personas to create an app that fit their restaurant's needs.

Rand's method involves running Adwords campaigns that target keywords in your prospective niche and pointing the ads at various landing pages on your site.

The firm's Mandarin site, targeting Internet users in mainland China and beyond, can be viewed at www.cobalt27.cn.

In this guide, you'll learn why, when, and how to target your on - site displays — pop ups, flyouts, banners, bars, and more — to deliver the right message to the right visitor at the right time.

Sodexo has a central role in achieving waste reduction targets and is strengthening its efforts to eliminate food waste at every client site, with a top priority to prevent waste from occurring.

In the winter of 1983, Western State coach Ken MacLennan set up targets and a special loop for Thompson at John Rozman's ranch, site of the Western State ski - training center.

I think most on this site would argue this is the general consensus of targets at # 6 or in the upper first.

He was actually starting his own Wolves blog at the time I launched this site and was quickly identified as my chief transfer target; a deal I was able to wrap - up for nothing more than a pint in the Clarendon and a packet of ready salted.

The site will go into more detail about Liverpool's transfer targets, as well as providing news related to the deal and information on the players themselves, such as how they will fit in at LFC.

The major social media sites provide political consultants with the ability to target ads at very specific groups of people — with Facebook the primary vehicle for this approach, particularly in the UK, but with YouTube a very popular vehicle, particularly in the US.

When I surveyed the state and regional political blogs in the BlogAds network a few weeks ago, I was shocked at how few campaigns were bothering to advertise on sites that would seem to be precisely targeting the local activists they'd most want to reach.

Another example: the recent race for an at - large city council seat in the District of Columbia, which saw a candidate using geo - targeted Google content ads to send potential voters to his NationBuilder site.

«Since the loop has been found to be a key segment in prion protein aggregation, this site could be targeted for the development of new therapeutics designed to block prion conversion,» said Christina Sigurdson, DVM, PhD, associate professor at UC San Diego and UC Davis and senior author of the study.

«It is clear that antibiotics are not an effective treatment for these infections once established in the lung, so something else needs to be developed urgently, and targeting the infection at the site of entry before chronic infection develops is one way forward.»

Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, «Nuclear imaging using radiotracers gives the opportunity to put your arms around proof - of - concept very early in a drug discovery and development program by focusing the selection of doses to study on those proven to deliver enough drug to the target therapeutic sites.»

Breast cancer patients who have radiotherapy targeted at the original tumour site experience fewer side effects five years after treatment than those who have whole breast radiotherapy, and their cancer is just as unlikely to return, according to trial results published in The Lancet.

Specifically, at most of the in vitro cleavage sites, indels (representing off - target effects) were below 0.1 %, much lower than those at corresponding on - target sites, suggesting that the two Cpf1 proteins had virtually no off - target effects.

The genome - wide analyses showed that Cpf1 was highly specific, showing fewer off - target cleavage sites (6 for LbCpf1 and 12 for AsCpf1), compared to Cas9, cleaving at > 90 sites in the human genome (Fig. 1a).

«We wanted to utilize platelets» intrinsic tendencies to accumulate at wounds and to interact with circulating tumor cells, for targeted delivery of immune checkpoint inhibitors» said Gu, «Interestingly, we found the antibody can be promoted to release from activated platelets in the surgical site, due to generation of small platelet - derived microparticles upon the platelet activation.

The team found that such occurrences in the genome are not uncommon; about 50 percent of the analyzed gRNAs had the potential to be affected by variants at their target sites.

This mapping pinpointed the origin of Owen's seizures in the left temporal lobe, enabling physicians to target the optimal location for placement of the NeuroPace RNS Neurostimulator, a titanium microprocessor measuring about one by two inches, which is connected to electrodes implanted at the site of seizure origin.

However, the reality is that nanocarriers may not always reach their intended target in sufficient numbers because of a constraint on their ability to transit through the blood vessel wall at the tumor site, leading the encapsulated drugs to be diverted or lost before they can deliver their payload.

«Current efforts to develop therapies against age - related diseases target these disorders one by one,» says Dr. Dan Ehninger, research group leader at the DZNE site in Bonn.

Nakano says UAB will be the only site in the Deep South for this unique trial aimed at a molecular target in glioma stem cells, a target that is different from the ones described in the Cancer Research paper.

Scientists can guide the scissors to the place they want to cut in an organism's genetic instruction book with a guide RNA that matches DNA at the target site.

In early experiments, the group observed that these off - target effects could occur at some DNA sites with nearly the same frequency as the desired edits.

A new field project, led by SLAC researchers and the DOE Office of Legacy Management, is using X-ray techniques to target long - lived groundwater contamination (large dark brown area) at former uranium ore processing sites in the floodplains of the upper Colorado River basin.

By targeting this enzyme in relevant plant species, it may be possible to produce TNT resistant plants to revegetate and remediate explosives at contaminated sites such as military ranges and manufacturing waste sites.

A new study shows that a 70 - year - old malaria drug can block immune cells in the liver so nanoparticles can arrive at their intended tumor site, overcoming a significant hurdle of targeted drug delivery, according to a team of researchers led by Houston Methodist.

In both cases, the idea is to target an enzyme that cuts both strands of the double helix at a specific site.

When inside the zygotes, the gRNA will seek out its target among the 3 X 109 nt of genetic content in the mouse genome and the Cas9 enzyme will make a cut at the target site.

For editing the genome, this system makes use of 3 components, a guide RNA (gRNA) of about 125 nt that specifies the target, the Cas9 endonuclease that creates the DNA double - strand break (DSB) at the target site, and a donor oligonucleotide or plasmid as the repair material if needed (for knock in models).

In parallel, built within this integrated platform, both SGC sites conduct several, non-overlapping scientific programmes aimed at exploring pioneer targets and biology.

Finch will incorporate its novel drug delivery technology to enable the targeted release of microbes at the site of the C. difficile infection in the colon.

The higher the amount of fluorescence, the better that gRNA is at causing a double stranded break at the target site, allowing the two halves of EGFP to recombine by homology directed repair, and resulting in the expression of EGFP.

Graphical representation of indels created at the CD81 target site in different CRISPR / Cas9 - edited hiPS cell clones.

After analyzing 964 sites cleaved in vitro by different 11 sgRNAs and measuring indel frequencies at hundreds of off - target sites in cells, we propose an off - target scoring system of each target site for minimizing CRISPR - Cas9 off - target effects in the human genome.

The way the nanomedicines were designed enabled this biological therapeutic to be released at the target site, the atherosclerotic plaque, in a controlled manner.

While it's extremely precise, it occasionally modifies DNA at similar sites elsewhere in the genome instead of the target gene.

These potential off - target sites were analyzed by DNA sequencing, but no unwanted mutation occurred at these genomic sites in all cloned goats (Table S2).

Insecticide resistance is typically associated with alterations to the insecticidal target - site or with gene expression variation at loci involved in insecticide detoxification.

Adult dating sites to be targeted specifically at those who just want to spice up their lives by having a good time on the internet in the comfort of your home.

Krygowski, 26, who majored in English at the University of Central Florida, is one of many bibliophiles who has signed up for Alikewise.com, a relatively new dating site targeting her kind.

Been used to a couple of online dating sites, especially targeted at Ukrainian and Russian woman, I must say in all honesty, I was disgusted at some of them and the way men are mislead and deceived out of their money!!

Furthermore, their survey was conducted in conjunction with JDate, an online dating site targeted at Jewish daters.

He spoke about the Malaysia - based dating platform, TheSugarBook: «But what is of greater concern is that the site targets young people who are in their late teens and early 20s, even while they are still students at polytechnics or universities.»