Not exact matches
In particular, as disclosed in filings with the U.S. Securities and Exchange Commission, Amarin's ability to effectively develop and commercialize Vascepa will depend in part on its ability to continue to effectively finance its business, efforts of third parties, its ability to create market demand
for Vascepa through education, marketing and sales activities, to achieve increased market acceptance of Vascepa, to receive
adequate levels of reimbursement from third - party payers, to develop and maintain a consistent source of commercial supply
at a competitive price, to comply with legal and regulatory requirements in connection with the sale and promotion of Vascepa and to maintain patent protection
for Vascepa.
If,
at some given
level of prices, I consider an average money balance of $ 1000
adequate for my needs, then, if prices fall to half that original
level, $ 500 will serve me just as well as a $ 1000 did before.
Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing
levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the
level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain
adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy
levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements
for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.
To get a proper and
adequate understanding of human freedom, one has to see man in the total context of evolution,
for freedom did not start with man; it had its evolutionary roots
at the infrahuman
level.
Birch and Cobb maintain that the ecological model is more
adequate than the mechanical model
for explaining DNA, the cell, other biological subject matter (as well as subatomic physics), because it holds that living things behave as they do only in interaction with other things which constitute their environment (LL 83) and because «the constituent elements of the structure
at each
level (of an organism) operate in patterns of interconnectedness which are not mechanical» (LL 83).
But one of the criticisms
levelled at the big Frenchman, no matter how well he was playing, was that he was not an
adequate replacement
for the Dutchman.
For the average child (keeping in mind individual kids may be exceptions to these guidelines), an acceptable amount of homework per night is as follows: — Elementary school: approximately 10 minutes or so per grade
level — Middle school: an hour or so — High School: 2 to 2-1/2 hours Any homework beyond these limits is no longer providing any advantage, and is probably cutting into those things that do provide advantages like
adequate sleep and what we
at Challenge Success call «PDF» — that is, play time, down time and family time.
Instead, there is an «
adequate intake
level» set by the Institute of Medicine
at 370 mg of sodium per day
for babies 6 - 12 months old.
Forecasting numbers
for instance may on the one hand facilitate a planning process that ensures
adequate capacity
for newcomers, especially
at a city or local
level, but on the other it can feed a frenzied public discussion
for whom any number is too many.
7.2.3 Use reasonable endeavors to ensure that the Server has
adequate capacity and bandwidth to support the usage of the Licensee
at a
level commensurate with the standards of availability
for information services of similar scope operating via the World Wide Web; as such standards evolve from time to time over the term of this License;
It means that women somehow have less of a tendency to apply, even if they are
at an
adequate level of qualification — and this is the case
for both younger and more established scientists.
«People
at risk of bone diseases, have seasonal depression, or are obese should have their physicians measure vitamin D
levels to ensure they're
adequate, but
for many, the best way to ensure
adequate blood
levels of the vitamin is from sun exposure, healthy diet, being active and maintaining a normal body weight.»
People with
adequate exercise
levels met the AHA's recommendations, those with intermediate
levels exercised vigorously
for up to 74 minutes per week or exercised moderately
for less than 149 minutes a week, and those classified as poor didn't exercise
at all.
Cellect where additional supplementation maybe needed Micronutrient Blood Test Information Testing Outside the US Recommendation on B vitamins where needed What if I don't have access to the testing Bed bound and have not had any nutritional supplementation Serious health issues created by a lack of B vitamins Vitamin B6; vital
for energy production and essential in transporting oxygen throughout the body Test case observations «The Doctor That Looked
at Hands» B6 deficiency; example edema in pregnant woman from being water logged; some losing up to 50 pounds of water weight in a few days Dr Ellis recommendation
for the correct B6 product and proper dosage Thoughts on Carpal Tunnel Syndrome and proper dosage
Adequate Vitamin D
level and proper dosage Dr Mercola's comments on the safety of tanning beds Testing Vitamin D deficiency and understanding the test is extremely important Vitamin D deficiencies linked to
The stated goal is to help Americans reduce sodium intake to
levels recommended by the Institute of Medicine (IOM) in 2004 and 2005, termed AI (
for adequate intake), which were set
at 1500 mg per day (3.7 grams salt)
for adults up to age fifty, 1300 mg per day (3.3 grams salt)
for adults between fifty and seventy, and 1200 mg per day (3 grams salt)
for adults older than seventy.
While it has commonly been thought that Americans» intake of essential micronutrients is
adequate, evidence indicates that damage occurs
at nutrient
levels higher than those known to cause acute deficiency disease and, in some individuals (e.g., those with SNPs resulting in lessened KM), it is obvious that higher than DRI
levels of the associated enzyme co-factors are necessary
for optimal function.
For your testosterone
levels, looking
at total only will not give an
adequate picture.
For those three reasons, you will almost certainly fail to achieve magnesium levels adequate for acne by focussing on food, at least in the early days of your acne que
For those three reasons, you will almost certainly fail to achieve magnesium
levels adequate for acne by focussing on food, at least in the early days of your acne que
for acne by focussing on food,
at least in the early days of your acne quest.
Like vitamin D, vitamin K intake
at the RDA is
adequate for basic needs but may not be sufficient
for optimal
levels for health, which may require a dosage still within the safe range but higher than what can be achieved with food.
An
Adequate Intake (AI)
for Total Fiber in foods is set
at 38 and 25 g / d
for young men and women, respectively, based on the intake
level observed to protect against coronary heart dis - ease.
[To date, there are an increasing number of scientists who have long since departed from that scientific philosophy — and are seeking another more
adequate explanation
for the lack of transitional life forms in the fossil record or the increasing irreducible complexity of living things
at the cellular
level which appear to be by design rather than random modification.]
Picture quality improves considerably as soon as the director's credit is off the screen, and stays
at a fairly high
level for the duration, with
adequate (not exceptional) shadow detail.
For example, the Gallup / Education Week poll found that just two percent of superintendents strongly agree that their school district is getting
adequate support
at the federal
level to implement Common Core — and 56 percent strongly disagree with that statement.
Researchers found that just 36 per cent of five to seven year olds were
at an
adequate level of fitness, compared with 32 per cent of those aged eight to nine and 33 per cent
for children aged in their final year of primary education.
All of this virtually guarantees shortages, or recruitment difficulties, in some fields and schools
at some time, even if the overall
level of resources
for pay and benefits in the district are more than
adequate.
The New York state early childhood program monitoring protocol,
for example, includes cumbersome requirements that don't have a clear connection to improved student learning — such as a «block building area with an
adequate supply of blocks in varied sizes that is organized and labeled» and a posted daily schedule that is «referenced daily, represented in pictures and words, and displayed
at children's eye
level.»
In New York, the state sends in program monitors to assess if a pre-K classroom has a «block building area with an
adequate supply of blocks in varied sizes that is organized and labeled,» «a private space
for each child's possessions,» and a posted daily schedule that is «referenced daily, represented in pictures and words, and displayed
at children's eye
level.»
Ironically, however, it is not clear that these growth models would fulfill the more simplistic federal requirements
for adequate yearly progress, which dictate that the performance of students
at each grade
level be measured against a fixed standard of proficiency.
Program monitors are required to note,
for example, if a pre-k classroom doesn't have a «Block Building area with an
adequate supply of blocks in varied sizes that is organized and labeled,» or «a private space
for each child's possessions,» or a posted daily schedule that is «referenced daily, represented in pictures and words, and displayed
at children's eye
level.»
To make
adequate yearly progress, or AYP, under the federal law, schools and districts must meet annual targets
for the percentage of students who score
at least
at the proficient
level on state reading and mathematics tests, both
for the student population as a whole and
for certain subgroups of students.
• The requirements
for adequate yearly progress and school improvement apply equally to high schools and elementary schools, yet it is not clear that they make as much sense
at the secondary
level.
Over the years, efforts
at the state and federal
levels have been appropriately placed on providing
adequate funding
for preschool and elementary education programs.
The Student - to - School Nurse Ratio Improvement Act of 2013 will create a pilot demonstration grant program that allows federal assistance
for educational agencies
at the local
level to target schools with the least
adequate school nurse to student ratios.
Designed to identify the
level of funding needed to deliver an
adequate education to every student in a state and sensitive to each child's needs, the Evidenced Based Model ensures that the distribution of education funding is equitable, and accounts
for the cost of overcoming «
at risk» factors.
While public education spending is
at historic
levels and is already the largest portion of our state budget — about 55 percent overall (K - 12, community colleges, and IHL) and around 40 percent
for K - 12 alone — legislative leaders have begun preparing to «fully fund» the Mississippi
Adequate Education Program formula should Initiative 42 pass.
«The mayor needs to be sure
adequate school -
level supports are put into place before instituting a significant, untested policy that may penalize otherwise successful students,» said Miriam Greenberg, director of education and communications
for the Center
for Education Policy Research
at Harvard University.
It is our goal to provide financial leadership to the Chicago Board of Education according to government regulations, Board policies and sound financial practices; to maintain the fiscal integrity of the organization; to develop internal and external partnerships; to educate students in a safe and well - rounded environment; and to work with leaders
at the federal, state, and local
levels to ensure
adequate funding and support
for educational initiatives.
a school finance formula based on individual student needs, which provides
adequate and equitable funding
for public schools, and is funded through a balanced tax policy
at both the state and local
levels.
It is expected that teachers will make a concerted effort to have students use the program consistently and
for adequate amounts of time so that they benefit from the instruction and practice activities
for all of the activities
for at least one
level.
I think that most people are starting to recognize that funding education
at 2008
levels by the year 2021 is not sufficient to pay
for an
adequate education (hence tuition increases
at UC system)(hence furlough days and increased class sizes
at my District) especially if the State now wants to mandate that Districts increase their contribution to CalSTRS and CalPERS.
According to JPS spokesman Sherwin Johnson, «the current [Mississippi
Adequate Education Program] formula uses a base student cost of $ 5,381.52;
at the current funding
level... our actual funding is
at $ 4,882.77 base student cost» — a difference that puts the district $ 498.75 in the hole
for every student enrolled, a deficit that runs into the millions.
Performance on each school - quality indicator is rated
at one of three
levels:
Level One (meets or exceeds the state standard
for the indicator or making
adequate improvement),
Level Two (near the standard or making sufficient progress) or
Level Three (below the standard).
One of the first obstacles to this kind of initiative —
at least
at the public school
level — is
adequate technology education
for teachers in order to prepare them
for their roles as digital facilitators.
It is necessary to check the protein content
at the
adequate level because the lower
level in the diet is risky
for dogs.
For any island destinations or remote areas we recommend you have
at least the Virtuoso Classic policy
level provide
adequate medical - evacuation coverage
levels.
This latest report was made
at the conclusion of these negotiations during which almost no progress was made in defining equity under UNFCCC by the Ad Hoc Working Group on Durban Platform
For Enhanced Action (ADP), a mechanism under the UNFCCC that seeks to achieve a
adequate global climate agreement, despite a growing consensus among most observers of the UNFCCC negotiations that nations need to align their emissions reductions commitments to
levels required of them by equity and justice if the world is going to prevent extremely dangerous climate change.
«While Directive 98/84 is intended to ensure
adequate legal protection
at EU
level for the services concerned in order to promote trade in those services within the internal market, the contested decision, by authorising the signing of the Convention on behalf of the European Union, is intended to introduce similar protection in European non-member countries, in order to promote the supply of such services to those States by EU service providers.
It's important
for those in the midst of a divorce to make sure they have
adequate legal representation because it's difficult to have such decisions reversed
at the appellate
level.
Now, the further placement (after Article 3 of Regulation EC, EURATOM No 2988/95 on the protection of the European Communities financial interests) of a limitation period
at the EU
level (with the adoption of Directive EU / 2017/1371 on the fight against fraud to the Union's financial interests) makes its European - oriented upgrade still necessary, and leaves the controversial issues concerning its real nature and its
adequate regulation
for crimes affecting the EU financial interests open to further debate.
Would this stricter approach accelerate the need
for harmonization
at the EU
level, as Member States would begin seeking to find an
adequate level of protection EU - wide?