Sentences with phrase «at adequate levels in»

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In particular, as disclosed in filings with the U.S. Securities and Exchange Commission, Amarin's ability to effectively develop and commercialize Vascepa will depend in part on its ability to continue to effectively finance its business, efforts of third parties, its ability to create market demand for Vascepa through education, marketing and sales activities, to achieve increased market acceptance of Vascepa, to receive adequate levels of reimbursement from third - party payers, to develop and maintain a consistent source of commercial supply at a competitive price, to comply with legal and regulatory requirements in connection with the sale and promotion of Vascepa and to maintain patent protection for VascepIn particular, as disclosed in filings with the U.S. Securities and Exchange Commission, Amarin's ability to effectively develop and commercialize Vascepa will depend in part on its ability to continue to effectively finance its business, efforts of third parties, its ability to create market demand for Vascepa through education, marketing and sales activities, to achieve increased market acceptance of Vascepa, to receive adequate levels of reimbursement from third - party payers, to develop and maintain a consistent source of commercial supply at a competitive price, to comply with legal and regulatory requirements in connection with the sale and promotion of Vascepa and to maintain patent protection for Vascepin filings with the U.S. Securities and Exchange Commission, Amarin's ability to effectively develop and commercialize Vascepa will depend in part on its ability to continue to effectively finance its business, efforts of third parties, its ability to create market demand for Vascepa through education, marketing and sales activities, to achieve increased market acceptance of Vascepa, to receive adequate levels of reimbursement from third - party payers, to develop and maintain a consistent source of commercial supply at a competitive price, to comply with legal and regulatory requirements in connection with the sale and promotion of Vascepa and to maintain patent protection for Vascepin part on its ability to continue to effectively finance its business, efforts of third parties, its ability to create market demand for Vascepa through education, marketing and sales activities, to achieve increased market acceptance of Vascepa, to receive adequate levels of reimbursement from third - party payers, to develop and maintain a consistent source of commercial supply at a competitive price, to comply with legal and regulatory requirements in connection with the sale and promotion of Vascepa and to maintain patent protection for Vascepin connection with the sale and promotion of Vascepa and to maintain patent protection for Vascepa.

This isn't to say that stocks can't deliver adequate returns between now and some narrow set of future dates, but to expect that stocks purchased at these levels will deliver attractive long - term returns in general requires the assumption that current valuations will remain elevated into the indefinite future.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

If the problem of sustaining this human impetus does not trouble the theorists I have referred to, it is, I suppose, because they assume that cases of revulsion will be as exceptional in the future as they have been in the past — that a sufficient degree of physical health or euphoria will maintain vital pressure at a positive level, moderate but adequate, within the human mass.

To get a proper and adequate understanding of human freedom, one has to see man in the total context of evolution, for freedom did not start with man; it had its evolutionary roots at the infrahuman level.

«Although such [explicit] revelation can not be necessary to the constitution of human existence, it can very well be necessary to the objectification of existence, in the sense of its full and adequate understanding at the level of explicit thought and speech.»

Birch and Cobb maintain that the ecological model is more adequate than the mechanical model for explaining DNA, the cell, other biological subject matter (as well as subatomic physics), because it holds that living things behave as they do only in interaction with other things which constitute their environment (LL 83) and because «the constituent elements of the structure at each level (of an organism) operate in patterns of interconnectedness which are not mechanical» (LL 83).

At the fourth level are Adequate families in which there exists more intimacy, flexibility and openness to individuality.

The medieval claims that God is impassible, while totally in adequate in relation to the God of the incarnation, of the cross — that is, inadequate in relation to God at the level of creativity - characterization — seems quite appropriate to the creator ex nihilo.

The middling performance levels with only sparks of quality execution, seemed to echo the topsy - turvy nature of the whole club's talent level and ability at the time; matched by adequate Cup runs and disappointing league finishes in the Europa League spots.

For the average child (keeping in mind individual kids may be exceptions to these guidelines), an acceptable amount of homework per night is as follows: — Elementary school: approximately 10 minutes or so per grade level — Middle school: an hour or so — High School: 2 to 2-1/2 hours Any homework beyond these limits is no longer providing any advantage, and is probably cutting into those things that do provide advantages like adequate sleep and what we at Challenge Success call «PDF» — that is, play time, down time and family time.

He said that Wike's comment was a grand design to ensure that Ogoni people do not have adequate representation and strong voice in the state and at the national level.

Liberal Democrat home affairs spokesman Nick Clegg added: «Tagging has a very important role to play in ensuring that low level offenders and those at the end of their sentence are kept under adequate surveillance.

Municipal finances - in Syracuse and most other cities - have fallen so far out of balance that no solution will be adequate without reform at the state level, Miner says.

While this issue is being recognized at the professional and elite levels, many youth and collegiate athletic programs across the U.S. lack the adequate medical personnel, specifically concussion specialists, to handle these injuries on the sidelines in real time.

The fascinating content, beautiful illustrations and adequate level of complexity of the comics will stimulate children's interest in plants at a very young age.

The aim is to stimulate ethical reflection on normative aspects of relevant developments in the clinic and the lab, in order to contribute to adequate guidance, both in the clinic and at the level of society.

8/21/2007 Study Shines More Light on Benefit of Vitamin D in Fighting Cancer 600,000 cases a year of breast and colorectal cancer could be prevented each year by adequate intake of vitamin D, according to researcher A new study looking at the relationship between vitamin D serum levels and the risk of colon and breast cancer... More...

An adequate intake of Vitamin D has been proven in research studies to increase levels of testosterone, while at the same time, increasing sexual libido.

Cellect where additional supplementation maybe needed Micronutrient Blood Test Information Testing Outside the US Recommendation on B vitamins where needed What if I don't have access to the testing Bed bound and have not had any nutritional supplementation Serious health issues created by a lack of B vitamins Vitamin B6; vital for energy production and essential in transporting oxygen throughout the body Test case observations «The Doctor That Looked at Hands» B6 deficiency; example edema in pregnant woman from being water logged; some losing up to 50 pounds of water weight in a few days Dr Ellis recommendation for the correct B6 product and proper dosage Thoughts on Carpal Tunnel Syndrome and proper dosage Adequate Vitamin D level and proper dosage Dr Mercola's comments on the safety of tanning beds Testing Vitamin D deficiency and understanding the test is extremely important Vitamin D deficiencies linked to

Even fresh, unoxidized perilla oil stored at — 20C and fresh, unoxidized, purified DHA and EPA — the omega - 3 PUFAs found in fish oil and cod liver oil, — stored at — 80C, mixed into the diets of rats immediately before feeding, raised lipid peroxide levels in tissues considerably — even when rats were fed adequate vitamin E. 54

Your doctor might give you a B - 12 shot to pull your B - 12 level up to normal all in one shot as it were and a supplement will keep it at that adequate level.

While there is not yet definitive scientific proof, Garland suggests that much of the evolutionary process in cancer could be arrested at the outset by maintaining adequate vitamin D levels.

The stated goal is to help Americans reduce sodium intake to levels recommended by the Institute of Medicine (IOM) in 2004 and 2005, termed AI (for adequate intake), which were set at 1500 mg per day (3.7 grams salt) for adults up to age fifty, 1300 mg per day (3.3 grams salt) for adults between fifty and seventy, and 1200 mg per day (3 grams salt) for adults older than seventy.

While it has commonly been thought that Americans» intake of essential micronutrients is adequate, evidence indicates that damage occurs at nutrient levels higher than those known to cause acute deficiency disease and, in some individuals (e.g., those with SNPs resulting in lessened KM), it is obvious that higher than DRI levels of the associated enzyme co-factors are necessary for optimal function.

Also, in some cases, higher levels of SNS activity leading to vasoconstriction and anoxia in working muscles to maintain adequate central blood supply at maximal exercise intensities.

The pre-eminent curiosity that I retain regarding health practitioners is that specialists in nutrition on occasion appear to not possess the adequate level of biochemical grounding to explain the vital processes happening at the cellular level during fasting and through manipulation of eicosanoids (fatty acids), conversely from my personal experiences, experts in biochemistry don't apply their vast knowledge of these complex physiological systems to basic fundamentals of nutrition in a sensible, practical sense.

I know that the iron supplies in breast milk are adequate from birth — 6 months old, at which time iron levels in mother's milk lowers as baby should be eating iron - rich foods like liver starting around 6 months of age.

It all boils down to the right ratios: in the landmark British study (Mohr, PE; Br J Cancer 1996) researchers found that women with breast cancer whose progesterone level at the time of surgery was above the adequate level, had significantly improved chances of survival.

The Opotowski team, which found that low vitamin A levels had as great an effect lowering BMD as did high vitamin A levels, suggested that vitamin A deficiency may contribute to increased fracture risk by allowing bone matrix to grow faster than it can be mineralized.12 Indeed, although the net effect of vitamin A is to stimulate osteoclasts and slow the growth of osteoblasts, vitamin A also causes osteoblasts to secrete a variety of enzymes and other proteins that are important to bone mineralization, including osteocalcin, which is a protein that plays a direct role in attracting and binding calcium within the bone matrix.6 By slowing the growth of the matrix but increasing the rate at which it is mineralized, adequate vitamin A helps to ensure sufficient bone density.

For those three reasons, you will almost certainly fail to achieve magnesium levels adequate for acne by focussing on food, at least in the early days of your acne quest.

An Adequate Intake (AI) for Total Fiber in foods is set at 38 and 25 g / d for young men and women, respectively, based on the intake level observed to protect against coronary heart dis - ease.

Leucine stimulation of anabolic pathways is decreased in the presence of sufficient essential amino acids (EAAs)(69), indicating an increased basal synthetic rate with adequate EAA ingestion, thus highlighting the importance of consuming dietary protein at levels above the current RDA during periods of energy deficit.

Although whole - body protein turnover measurements suggested that consuming dietary protein at RDA levels was adequate, nitrogen balance and resting metabolic rate were lower in response to energy deficiency, which corresponded to a significant decrease in FFM.

[To date, there are an increasing number of scientists who have long since departed from that scientific philosophy — and are seeking another more adequate explanation for the lack of transitional life forms in the fossil record or the increasing irreducible complexity of living things at the cellular level which appear to be by design rather than random modification.]

All in all, «Dirk Gently» tries to be about half a dozen shows at once, and none of them rise to the level of adequate.

The NCLB accountability system divides schools into those in which a sufficient number of students score at the proficient level or above on state tests to meet Adequate Yearly Progress (AYP) benchmarks («make AYP») and those that fail to make AYP.

Researchers found that just 36 per cent of five to seven year olds were at an adequate level of fitness, compared with 32 per cent of those aged eight to nine and 33 per cent for children aged in their final year of primary education.

All of this virtually guarantees shortages, or recruitment difficulties, in some fields and schools at some time, even if the overall level of resources for pay and benefits in the district are more than adequate.

Others included pride in working at the school, adequate resources, good support from and feeling valued by school management, having an effective governing body and getting paid appropriately according to level of responsibility.

The New York state early childhood program monitoring protocol, for example, includes cumbersome requirements that don't have a clear connection to improved student learning — such as a «block building area with an adequate supply of blocks in varied sizes that is organized and labeled» and a posted daily schedule that is «referenced daily, represented in pictures and words, and displayed at children's eye level.»

In New York, the state sends in program monitors to assess if a pre-K classroom has a «block building area with an adequate supply of blocks in varied sizes that is organized and labeled,» «a private space for each child's possessions,» and a posted daily schedule that is «referenced daily, represented in pictures and words, and displayed at children's eye level.&raquIn New York, the state sends in program monitors to assess if a pre-K classroom has a «block building area with an adequate supply of blocks in varied sizes that is organized and labeled,» «a private space for each child's possessions,» and a posted daily schedule that is «referenced daily, represented in pictures and words, and displayed at children's eye level.&raquin program monitors to assess if a pre-K classroom has a «block building area with an adequate supply of blocks in varied sizes that is organized and labeled,» «a private space for each child's possessions,» and a posted daily schedule that is «referenced daily, represented in pictures and words, and displayed at children's eye level.&raquin varied sizes that is organized and labeled,» «a private space for each child's possessions,» and a posted daily schedule that is «referenced daily, represented in pictures and words, and displayed at children's eye level.&raquin pictures and words, and displayed at children's eye level.»

Program monitors are required to note, for example, if a pre-k classroom doesn't have a «Block Building area with an adequate supply of blocks in varied sizes that is organized and labeled,» or «a private space for each child's possessions,» or a posted daily schedule that is «referenced daily, represented in pictures and words, and displayed at children's eye level.»

Under that system, whether a school makes Adequate Yearly Progress is determined primarily based on the share of students scoring at proficient levels in math and reading in a given year.

Designed to identify the level of funding needed to deliver an adequate education to every student in a state and sensitive to each child's needs, the Evidenced Based Model ensures that the distribution of education funding is equitable, and accounts for the cost of overcoming «at risk» factors.

In contrast to the traditional methods of measuring school effectiveness (including the adequate yearly progress system set up under NCLB), value - added models do not look only at current levels of student achievement.

It is our goal to provide financial leadership to the Chicago Board of Education according to government regulations, Board policies and sound financial practices; to maintain the fiscal integrity of the organization; to develop internal and external partnerships; to educate students in a safe and well - rounded environment; and to work with leaders at the federal, state, and local levels to ensure adequate funding and support for educational initiatives.

Unfortunately, many of the most important features of the plan, such as extended learning time in core subjects and a longer school day to include enrichment in art, music, and academic tutoring, were never funded at adequate levels by the state.

He also pointed to «a decade of disinvestment» in California's schools, and said that the school finance plan still falls short of what many regard as an «adequate» level of funding to ensure that children succeed at their optimal levels.

According to JPS spokesman Sherwin Johnson, «the current [Mississippi Adequate Education Program] formula uses a base student cost of $ 5,381.52; at the current funding level... our actual funding is at $ 4,882.77 base student cost» — a difference that puts the district $ 498.75 in the hole for every student enrolled, a deficit that runs into the millions.