Sentences with phrase «at cell receptors»

Not exact matches

At this time, trials and plans for its other CD19 - directed chimeric antigen receptor (CAR) T - cell product candidates, including JCAR017, are not affected.

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

Specifically, when capsaicin frequently binds to receptors within the human central nervous system's TRPV1 channel (the sensory receptor system for pain and heat detection), these receptors deplete and this depletion results in a whole host of benefits for the central nervous system at large, including terminating cancer cells, increasing the metabolic rate and digestive efficiency, increasing circulatory blood flow, and combatting inflammation, and making you feel better about the world.

«Once this novel tumor - homing agent binds to the EphA2 receptor, the oncogene functions as a cancer - specific molecular Trojan horse for paclitaxel, carrying the drug inside the cancel cell, killing the cell, and thwarting metastasis,» said Maurizio Pellecchia, a professor of biomedical sciences at UCR's School of Medicine who led the research.

Baier looked at the genetic mutations in the «frozen» fish and found one in the glucocorticoid receptor, a protein that is found in almost every cell and that senses cortisol — a hormone involved in the stress response.

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

p11 increases localization of 5 - HT1B receptors at the cell surface.

The paper, by V. Hegenauer at University of Tübingen in Tübingen, Germany, and colleagues was titled, «Detection of the plant parasite Cuscuta reflexa by a tomato cell surface receptor.»

«We were looking at the amino acid sequences of T cell receptors when Tomer asked what the corresponding epitope was for a particular receptor,» Thomas said.

Glutamate released at the end of one cell binds to receptors on the adjacent cell, starting up a signal inside that cell.

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

Physicist Marshall Stoneham and his colleagues at University College London report they have constructed a specific mechanism based on the properties of so - called G - protein coupled receptors, which project from olfactory cells inside the nose.

In the current study, Frank Longo, MD, PhD, and others at Stanford University, tested LM22A - 4, a drug that specifically binds to and activates the BDNF receptor TrkB on nerve cells, in mice that model the disorder.

The current paper shows that treating with retinoids simultaneously with anti-estrogen therapies may pull cofactors for progesterone receptors away from their posts, disallowing their ability to open DNA at the point of CK5 and keeping the growth of dangerous CK5 + cells in check.

This is how progesterone boosts CK5 + cells — like tiny gatekeepers, progesterone receptors and their cofactors sit in front of the gene CK5, opening the doors of DNA to be read at this point.

In the new work, Evans» group focused on estrogen - related receptor gamma (ERRγ), a gene that is active at high levels in brown fat cells.

A special receptor on cells that line the sinuses, throat and lungs evolved to protect mammals from developing a range of allergies and asthma, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health.

The accuracy for human eye and hair color is much higher at 0.9, and chronological age — based on T cell receptors — is the same.

Now, scientists from the Perelman School of Medicine at the University of Pennsylvania reveal that the release of AMPs is partially controlled by bitter taste receptors in the upper airway on a cell previously identified in animals and only recently in humans known as solitary chemosensory cells (SCCs).

The teams at AFB International and Integral Molecular studied the behavior of two different cat bitter taste receptors in cell - based experiments, investigating their responsiveness to bitter compounds, and comparing these to the human versions of these receptors.

«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»

Although SB 247464 doesn't work with human cells, the discovery will spur the pharmaceutical industry's search for protein - mimicking drugs, says Mark Goldsmith, who studies cytokine receptors at the University of California, San Francisco.

Liang Xu, Ph.D. member of the KU Cancer Center's Drug Discovery, Delivery and Experimental Therapeutics program and associate professor of molecular biosciences at KU, has discovered that targeting a cell - surface receptor called «CD44s» can block pancreatic tumor formation and recurrence after radiotherapy.

Next, Lu et al. found that 3BNC117 was not effective at clearing infected cells when their Fcγ receptor was mutated or blocked, suggesting that this receptor is a key mechanism behind 3BNC117 - mediated clearance of HIV - infected cells.

So it's probably the actions of cyclamate at saccharin's bitter receptors that help block the bitterness, Behrens and his colleagues report September 14 in Cell Chemical Biology.

Specifically, the study — reported online in The Journal of Infectious Diseases — shows that E. coli K1 modulates the protein peroxisome proliferator - activated receptor - gamma (PPAR - γ) and glucose transporter - 1 (GLUT - 1) levels at the blood - brain barrier in human brain microvascular endothelial cells.

When PDGF arrives at the cell surface, it binds to a protein called PDGF receptor tyrosine kinase (PDGF RTK).

At that point, physicians switch to other drugs, such as enzalutamide, which block testosterone's ability to bind to receptors within prostate cancer cells.

Kelly M. Standifer, professor and chair of pharmaceutical sciences at the University of Oklahoma, points out that the researchers tested the compounds» potency in nonneuronal cells forced to express the receptors.

In these vesicles, we saw the EGFR and HER2 receptors being broken down, but we also saw our negative control receptor, c - MET,» said Dent, who is the Universal Corporation Chair in Cancer Cell Signaling and a member of the Cancer Cell Signaling research program at Massey.

«The NILR1 is the genetic code for a receptor protein that is localized to the surface of plant cells and is able to bind and recognize other molecules,» says Prof. Florian Grundler, chair at the Department of Molecular Phytomedicine at the University of Bonn.

By providing a first look at the structure of the protein complex that includes FGF23 and its co-receptors, the FGF receptor and a-Klotho, the most recent study challenges the long - accepted belief that only the cell - attached form of aKlotho can serve as a receptor for FGF23 and hence that FGF23 action is restricted to tissues having the cell - attached form.

Kenyon cells make up only about 4 % of the entire fly brain and are extremely sensitive to inputs triggered by odors, in which only two connections between neurons, called synapses, separate them from the receptor cells at the «front end» of the olfactory system.

More specifically, tisagenlecleucel is a type of chimeric antigen receptor T cell (CAR - T) therapy, a technique pioneered by immunologist Carl June and colleagues at the University of Pennsylvania.

As Louis H. Miller, Head of Malaria Cell Biology Section at the National Institutes of Health notes, «The findings on the liver receptor EphA2 for malaria parasite sporozoite invasion of liver cells is a critically important advance and might allow us to devise new strategies to block parasite infection.»

According to the 6 April report in the Journal of Assisted Reproduction and Genetics, researchers at Guangzhou Medical University in China attempted — with limited success — to modify the CCR5 gene, which codes for a cell receptor that the HIV virus uses to enter T cells.

«SynNotch receptors essentially allow us to confine the T cell response at the site of disease with the goal of enhancing the ability of the T cell to, for example, overcome the inhospitable microenvironment of a solid tumor.

To address such obstacles, Roybal, now an assistant professor at the University of California, San Francisco and his colleague Leonardo Morsut turned to a signaling molecule on T cells called the Notch receptor, known to be involved in several developmental and biological processes.

In collaboration with researchers at the Lead Discovery Centre of the Max Planck Society in Germany, they developed an inhibitor molecule directed against the receptors that are regulated by Cbl - b in NK cells, the so called TAM - receptors.

Black people are particularly at risk, given the study's finding that suPAR activates its receptor on kidney cells that then attract the APOL1 risk proteins.

The experimental drug cediranib blocks the cell surface receptor VEGF, which stimulates the growth of new blood vessels to feed the growth of tumours,» explains study researcher Dr Paul Symonds, of the Department Cancer Studies & Molecular Medicine at the University of Leicester, UK.

But Clark and her colleagues have taken a new approach: instead of looking during the height of activity, they examined lesion sites after treatment, and identified T cell receptors of cells at these sites that were shared across psoriatic patients but not found in healthy individuals or those with other skin conditions.

The scientists demonstrated that, via so - called NMDA receptors, the active ingredient stimulated the pancreatic beta cells to secrete more insulin at raised blood sugar levels.

The researchers are now looking at how ICOS signals can be altered to diminish autoimmune disorders and augmented for more effective vaccine development, and are beginning research on how ICOS signaling may benefit Chimeric Antigen Receptor - T cell (CAR - T) therapies, which involves engineering of patient's own immune cells to recognize and attack their cancers.

Key to the researchers» efforts to track oxytocin at work in individual brain cells was use of an antibody developed at NYU Langone that specifically binds to oxytocin - receptor proteins on each neuron, allowing the cells to be seen with a microscope.

Geneticist at the University of Toronto in Canada, the first to clone the T - cell receptor, discusses how a scientific breakthrough can change your life:

The team led by John Hogenesch, PhD, a professor of Systems Pharmacology and Translational Therapeutics in the Perelman School of Medicine at University of Pennsylvania and Jason DeBruyne, PhD, a former postdoctoral fellow in the Hogenesch lab and now an assistant professor at Morehouse School of Medicine in Atlanta, applied their new method to identifying other clock partners that target a multipurpose cell nucleus receptor for disposal.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin — the active ingredient in chili peppers — produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.

«We were able to identify the receptor BAI3, a protein at the surface of myoblasts, as one of the crucial missing links in the fusion of muscle cells,» adds Dr. Côté.