Sentences with phrase «at copy number»

«The general approach of looking at copy number variation as the cause for genetic disease has probably taken one of those exponential — it's probably hyper --- exponential leaps,» he says.

Not exact matches

The first week numbers for «25» put the sultry singer at the head of an elite club of artists, including Britney Spears, Whitney Houston, Eminem and Lady Gaga, whose albums have debuted with more than 1 million U.S. copies.

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In this video I'm going to show you a great way to get better keywords out of the Google Adwords Keyword tool if you haven't seen the previous video you'll want to watch that video where I show you how to get better search volume numbers from both google adwords as well as some other sources to get better estimates for the amount of times that keyword is searched each month i'll put a link in the video here so that you can click that video if you haven't seen that yet let's get started now if you want better results from the Google Adwords Keyword planner you have to work a little differently than everyone else so most people come to the Google Adwords Keyword planner and they simply click on this search for new keywords using a phrase, website, or category and then they just paste a bunch of keywords into this text box so let's say as an example that these were our starting keywords ok so let's say we have the keywords «fishing tips» «fishing tackle» «fishing for bass» «fishing rod» and «fishing reel» what most people do is that they would simply come here and they would copy this they would paste it into this field and they would hit Search and they would get back their results and that's fine but one little tip that will help you get much better results is only paste in one key word at a time so instead of pasting all these in just paste in the single keyword «fishing tips» and then proceed from there to pull that those results up and you'll get this back if you click right here you can download the ideas you'll notice they're 701 here listed so if we download these ideas will download them to a CSV file comma separated value file you can open that with notepad you can open it with excel open office when you're finished putting all your ideas and individually you will now have a bunch of different common separate value files containing the keywords and the search volume I've already gone ahead and done that just to save time on the video but i want to show you what happens when you use this method versus just pasting in the keywords like most people do so here you'll see this column here represents these two columns here represent if we had pasted in all of the keywords at once and click search at google adwords keyword tool is one that showed you and you'll see we have a total of 706 results we got back when we did that this column this column here represents what happens when we paste one key word at a time and then download the file paste the second keyword download the file and then we just simply grab those terms and copy them and you'll see now we have a total of 1,915 keywords now what I've done with the highlighting here is to show you anything that's not highlighted in this column is a keyword we would not have gotten back had we pasted in all the keywords at once you can see there's lots and lots of keywords here we would not have seen know your competitors and the company's you're competing against they're using probably the simple method just pasting a bunch of keywords sitting search and then looking through those terms to find their terms if you will take the extra few minutes it takes doesn't take long to simply go in and paste one key word at a time you will get back a ton of great keywords that others aren't seeing because they're using this other method and in actuality when I ran the numbers there's a total of 3.8 million searches represented by these keywords here that you would miss if you simply just copied and pasted those five terms and hit search the Google Adwords Keyword planner once you've used the google keyword planner to find lots of new keyword ideas what do you do with all those keywords the biggest problem is that you can there are so many keyword tools out there you can get hundreds of thousands of keywords by spending a day using the different keyword tools but what you do with all that information the answer is a cool tool called keyword grouper pro and Keyword Grouper Pro is completely free there's not even an opt in you just simply download the tool now at the top of this video there's a link if you click that i'll show you exactly how to use keyword grouper pro doesn't matter where you got your keywords from i'm going to show you how to take those keywords group them into tight groups and then you can set up your campaigns and know exactly which groups represent buyers and once you know where the buyers are at you can simply focus your marketing in that area to make more profit in your business

Now if the true issue is so clearly defined in the article — THE ISSUE OF WHAT THE LOST MUST BELIEVE TO BE SAVED — and I believe it is, and like I said, I can scan my own copy of the article with with notes and numbering in my own handwriting — and if your position on this issue is so Biblically solid, then why do you not deal with the real issue at hand, rather than raising all these sorts of protests and all this fuss about the author that can be directly quashed by quotes from the articles?

Have a look at Everyday Harumi if you come across it, I bought a copy a few weeks ago, and there are quite a number of recipes I'm excited to try.

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So what we did was once the plates were dry was draw a circle — some I did and some J did — as I wanted us to look at numbers and symmetry but without J realising it so I drew a line down the middle of the plate — on one side I drew either 1, 2, 3, 4 or 5 circles and then J copied them on the other side of the line he did it really well.

At the end of voting, each observer gets a copy of the Voting Protocol with the final figures (turnout, votes given for each candidate, number of ballots used, number of ballots spoiled, etc.).

So for political judgment, the numbers from the copied table should maybe be corrected by including the percentage of adults who are taxed at 0 $.

A limited number of hard copies of Plan C will be available at the joint SLF / Liberator conference stall at the spring conference this weekend in Gateshead.

The researchers looked at a type of genetic change called copy number variants, which refers to the number of copies of genes in human DNA.

«Copy number variants in human DNA can be compared to repeated or missing paragraphs or pages of text in a book,» said senior author Dr. James R. Lupski, Cullen Professor of Molecular and Human Genetics at Baylor.

It utilizes specific, immobilized probes that can be interrogated using DNA from normal and diseased sources, providing a wealth of information on copy number changes throughout the genome at much finer resolution than has been previously achievable.

Now, researchers at the University of California, Los Angeles, have shown how to turn a regular smartphone into a portable, inexpensive microscope that accurately measures copy - number variations in seconds.

All patients had both CTCs with ALK rearrangements and CTCs with ALK copy number gain before treatment and at two months.

Analysis of CTC numbers at the different time points showed that the one measurement that was statistically significantly associated with progression - free survival was a change in the number of CTCs with ALK copy number gain over time.

Biotechnologist James Dale and colleagues at Queensland University of Technology in Brisbane, Australia, cloned a resistance gene named RGA2 from a type of wild banana that's impervious to TR4 and inserted it into the Cavendish, creating six lines with varying numbers of RGA2 copies.

First author Baoshan Xu, Ph.D., a former postdoctoral research associate in the Gerton Lab now starting his own lab at Sun Yat - sen University in China, worked with Hua Li, Ph.D., to use computational methods to count the number of copies of ribosomal DNA in normal and cancer cells of 162 patients from the eight projects.

Recently geneticists have taken a closer look at a genetic aberration previously considered rare: copy number variation (CNV).

The analysis suggests that about 1,000 copy number variations exist in each person, spanning at least 1 percent of the genome.

On January 9, a team, led by researchers at Massachusetts General Hospital (MGH) and Children's Hospital Boston, announced that it had found copy number variations — deletions of duplications of segments of genetic code that alter the number of copies of a gene a person carries — in 12 of 1,400 autism sufferers it was studying.

Mark Daly, an assistant professor of medicine at Harvard University Medical School and MGH as well as co-author of the NEJM study, notes that «It is extremely unusual to see these spontaneous deletions and duplications in a region that's usually a copy number — stable region.

About the same time, scientists at Cold Spring Harbor Laboratory in Long Island, N.Y., focusing on families with one autistic child, reported that an estimated 10 to 30 percent of all reported cases of autism may be caused by new (or spontaneous) mutations in the number of copies of genes in children (that were not found in either parent).

Something in the cell was inhibiting the trigger at other time points, ensuring the right copy number of centrioles was formed at the right time,» says Zitouni Sihem, co-first author of this study.

This suggests that the initial selection at this locus may have been independently driven by some factor other than AMY2B copy number.

A limited number of free copies are available at Fang's website, http://www.chemistry.mtu.edu/~shifang/.

This suggests that aside from neocentromere formation, mechanisms that reduce satellite copy number could account for the small amount of CentO at rice centromere 8.

In 2008, Wigler proposed that such cases, characterized by changes in gene copy number — duplicated or deleted genome segments that leave an individual with extra or missing copies of one or more genes — likely account for at least half of ASD cases.

Her thesis was entitled «Impact of copy number variation on chromatin interactions at the mouse 4qE2 chromosome region.»

In the present study, the researchers have developed a mass spectrometry - based method that is sensitive and reproducible in order to measure, at steady - state conditions, absolute protein copy numbers across human tissues and cell lines and compared these levels with the corresponding mRNA levels using transcriptomics.

No single approach can survey everything at once, but exome sequencing is advantageous because mutations, copy number changes, and zygosity changes can be characterized simultaneously.

Although their copy - number methods are based on «read» density, there are classes of mutations that require analysis at the level of the read.

Perhaps surprisingly, the authors find that somatic mutations occur at a continuous distribution in TNBC, and this appears independent of copy number alterations and tumor cellularity.

«Basically, this study shows that the genetic makeup of individual human embryonic stem cell lines is unique in the numbers of copies of certain genes that may control traits and things like disease susceptibility,» said Teitell, who also is an associate professor of pathology and laboratory medicine and a researcher at UCLA's Jonsson Comprehensive Cancer Center.

They showed that removal of the tails resulted in the retention of 1.4 to 7.8 times higher number of copies in four out of five colon - specific genes expressed at low levels after subtraction.

This is to accommodate small variants that occur at sites of copy number variation as well as in samples that are not pure: for example, due to tumor heterogeneity or sample mosaicism.

We aim to push its limits on all fronts to establish a technique which combines nanometre 3D resolution with maximum labelling efficiencies, absolute measurements of protein copy numbers, precise multi-colour measurements, high - throughput for large scale statistics and novel data analysis approaches, to address the vast array of exciting biological questions at the nanoscale, which are becoming accessible only now.

DNA copy - number analysis of cfDNA of patient 2 identified single copy loss at the BRCA2 locus (Supplementary Fig.

To identify additional alterations, the investigators looked at DNA copy number changes, or changes in gene number resulting from the deletion or amplification (multiplication) of sections of DNA in the genome.

For 1,317 distinct genes, both copies were found to have deleterious mutations in at least one individual, resulting in «human knockouts» for a remarkable number of new genes for whom human knockouts have never been reported.

Mapping the changes in copy number to the phylogeny of these Y chromosomes previously established by the Project identified at least 20 mutational events, and investigation of flanking paralogous sequence variants showed that the mutations involved flanking sequences in 18 of these, and could extend over > 30 kb of DNA.

Conversely, in both Eastern and Southwestern regions the Vgsc - 1014F alleles were close to fixation, whilst Ace1 - 119S allele frequency was 12 % (although frequencies may be underestimated due to copy number variation at both loci).

De novo copy number variants (dnCNVs) arising at multiple loci in a personal genome have usually been considered to reflect cancer somatic genomic instabilities.

In support of this threshold effect, doubling or tripling peel - 1 copy number among male - sired embryos did not produce a more severe phenotype, at least as measured by the onset of epidermal leakage (Figure 5D).

But this article is not footnooted properly, by which I mean clicking on the «little blue numbers» only links to an identical copy of the article at Dr. Mercola (assumedly this article was also written for them).

In the last year though a few competitors have popped up (see yesnomayb, a copy of the business model) and a number of free dating sites also started to eat away at traffic.

In comparison, The King of Fighters XIV, which also went on sale the same day, sold 23,242 copies that same week, coming in at number three.

Nintendo has also stated that the pre-order bundle is due to be available in limited numbers, so if you're tempted by the red Classic Controller Pro, copy of the game and three A1 - sized posters all electronically signed by the founder of Monolith Software, Tetsuya Takahashi, then be sure to place your pre-order at GAME or Gamestation.

If the product itself fails to ignite much excitement, at least the Blu - ray / DVD combo pack release of «I Am Number Four», also inclusive of a digital copy, delivers some nice extras.