Sentences with phrase «at different time points over»

The brains of the mice were analyzed at different time points over 22 months to map the spread of abnormal tau protein.

Not exact matches

In fact, each human gene can be traced back to a single ancestor at some point over the last few million years, but different individuals at different times, and this is entirely to be expected statistically.

In order to isolate the 3D structure of the chromosome during metaphase, the authors used a combination of chromosome conformation capture technologies (3C, 5C and Hi - C) developed by the Dekker lab over the last decade to map the points of contact along the mitotic chromosome in different cell types synchronized to divide at the same time.

Over time, an extensive fossil record of G. bulloides abundance at different points in history has accumulated on the ocean floor.

Analysis of CTC numbers at the different time points showed that the one measurement that was statistically significantly associated with progression - free survival was a change in the number of CTCs with ALK copy number gain over time.

Consequently, despite the extensive and highly successful efforts of many researchers to develop infection models in Drosophila, the outcomes of infection are often measured by end - points such as insect death (survival of a cohort of insects over time) or changes in cell morphology at fixed periods throughout infection (often monitored by staining different elements of the cytoskeleton).

They could then plug that information into models to see how much ice Greenland lost over the 20th century, as well as how that loss varied over time and at different points around the ice sheet.

Giovanni have practiced meditation daily (for the past 16 years, totaling over 7,000 hours at this point), read hundreds of books, tried several different practices, spent time on retreats with masters and instructors around the world, and nearly became a monk a couple of times.

At this point in time, the original Mega Man is over thirty years old, and even though the Mega Man Legacy Collections one and two are both brand - spanking - new, the games themselves clearly hearken back to a different era of electronic entertainment.

Still, these were different times in America's past, and peaceful coexistence didn't seem plausible at the time — a point Cooper reminds by forcing Blocker to endure a liberal diatribe over dinner with Lt. Colonel Ross McCowan (Peter Mullan), as his wife (Robyn Malcolm) verbalizes a more progressive modern view.

Oh well...:) But I plan to buy all 5 of these at some point over the years which is really the best part of GOTY awards for me... I don't have time to play a lot of different games so these awards whittle down the selection process for me quite a bit.

HUNDREDS OF ACTIVITIES TO COVER ALL 12 TOPICS IN GREAT DETAIL - I have covered as much vocabulary as possible (including the majority of the vocab lists in the textbook) and all key grammar points including MA grammar such as subjunctive / personal a. Theme 1 (ks3 revision / family / relationships / free time / customs and festivals)- over 45 activities Theme 2 (home and local area / social and global issues including healthy eating / travel and tourism)- over 85 activities Theme 3 (studies / life at school / post 16 options and future careers)- over 85 activities Key grammar - all 8 tenses, prepositions, personal a and 3rd person opinions, regular and irregular verbs practice in all tenses including irregular past participles, questions, connectives, time expressions, using different tenses simultaneously.

As a result, schools in the smallest decile were much more likely to be among the top 25 schools at some point over the period: Even though their mean gains were not statistically different, the smallest schools were 23 times more likely to win a top - 25 award than the largest schools.

The approach focuses on assessing and monitoring student growth over time and is underpinned by an understanding that students of the same age and in the same year of school can be at very different points in their learning and development.

Your cat's routine brings him to rest and to watch over his territory from different vantage points at different times.

- for Sonic's 25th anniversary last year, Iizuka received a task to deliver some sort of product - the target was «dormant fans» who used to play the SEGA Genesis, but haven't really played any games since - Iizuka met Christian Whitehead, which lead to the creation of Sonic Mania - there was talk of another port, but Iizuka thought fans would desire something new from the old games - this is the first time Iizuka partnered with a team of devs spread across various countries - Iizuka said this team had a greater passion to create - this was in comparison to companies that set decisions on a pre-determined schedule (in meetings, etc)- the team had so many features they still wanted to add after the beta version was complete - since there were only a few spots with text that needed to be localized, they could bring the game to more places quicker - the game has Japanese, English, French, Italian, German, and Spanish support - the Studiopolis stage is included due to receiving the most requests from the Sonic Mania development team - Iizuka actually considered reducing the amount of stages at one point in order to meet the development schedule - Sonic Mania doesn't really have much in the way of cut content like scrapped stages - since Sonic Mania was only distributed digitally, the team was able to continue working very close leading up to launch - this let them put in practically all ideas, and there are currently no plans for DLC - Iizuka recommended Flying Battery Zone for inclusion becaues he likes the music - he also likes when the player goes inside and outside the ship - Iizuka likes Mirage Saloon because the stage structure will be different depending on the player character chosen - Puyo Puyo gameplay was added because there was a Puyo Puyo game released in the west for the SEGA Genesis - this game was originally called «Dr. Robotnik's Mean Bean Machine», and the team thought it would make a fun boss battle - Iizuka didn't have plans to feature Blue Sphere in the special stages - the Blue Sphere special stages were brought over to Mania as a test, but ended up staying for the final game - the team felt the need to continuously connect stages from various eras, which is doe with the Phantom Ruby story - for Sonic Mania, it was decided that the technological limit would be set at SEGA CD, - this is higher than the Genesis but lower than Saturn - in creating a SEGA CD - grade special stage, they would intentionally make SEGA CD - grade polygons

-- Nintendo previously made Zelda games by making small areas and connecting them together — For Breath of the Wild, the team first had to figure out what needed to be placed on the map — Groups were created out of the over 300 devs to work on specific sections of the world — Game Informer's demo starts at Serenne Stable — Yammo runs this place — Link can rest in bed and restore health here — Stable also lets you store horses, meet with merchants, NPCs — Stables are located throughout the world — Each one is run by a distinct character — You can spend rupees on a more expensive bed, giving you an extra heart the next morning — These hearts are yellow and can't be recovered if you're hit in combat — Spending time by fires in the world passes time — Dynamic weather system in the game, with the world reacting as a result — Ex: when it starts raining, NPCs outside the stable quickly go inside — Beedle is back to sell you goods — Have to be careful during a thunderstorm, since your metal items can attract thunder — Metal weapons and shields can be discarded or thrown at enemies — Link can get killed by lightning — Difficulty dips / spikes depending on where you are, since you can go around it and avoid it until you're stronger — Over 100 Shrines — You can find an item that identifies Shrines — Discover a Shrine for it to be a fast - travel point — Shrines also give a Spirit Orb — Trade in orbs for unknown items — Dedicated team handled animal A.I. — Bears, wolves, deer move through the snow — You can get overwhelmed by enemies quickly — Link can keep multiple horses at a time — Affection / loyalty important with horses — Feed and take care of horses to raise their stats — Can call horses over to you, but horses need to be within a certain proximity to be called — Horses can be killed by enemies — Aonuma «wanted players to choose their own path», so no companion character in this game — Stamina meter encopasses sprinting, paragliding, climbing — Meter can be upgraded, but Nintendo won't say how — Different shields have different speeds and level of control for snowboarding — Can mine rocks which can be solid for rupees or used for crafting — Can place stamps to mark areas of interest — 100 of these symbols can be used on the map, including sword, shield, bow and arrow, pot, star, chest, skull, leaf, diamond — Every style of weapon has a unique set of animations and feel different — No invincible weapons in the game, Nintendo says — Zelda can get mad at you and scold you — Players can see the ending without seeing everything from the story — A certain element was added in the game to make for a more cohesive storyline — Most difficult Zelda game to make — Aonuma is still finding new things in the wover 300 devs to work on specific sections of the world — Game Informer's demo starts at Serenne Stable — Yammo runs this place — Link can rest in bed and restore health here — Stable also lets you store horses, meet with merchants, NPCs — Stables are located throughout the world — Each one is run by a distinct character — You can spend rupees on a more expensive bed, giving you an extra heart the next morning — These hearts are yellow and can't be recovered if you're hit in combat — Spending time by fires in the world passes time — Dynamic weather system in the game, with the world reacting as a result — Ex: when it starts raining, NPCs outside the stable quickly go inside — Beedle is back to sell you goods — Have to be careful during a thunderstorm, since your metal items can attract thunder — Metal weapons and shields can be discarded or thrown at enemies — Link can get killed by lightning — Difficulty dips / spikes depending on where you are, since you can go around it and avoid it until you're stronger — Over 100 Shrines — You can find an item that identifies Shrines — Discover a Shrine for it to be a fast - travel point — Shrines also give a Spirit Orb — Trade in orbs for unknown items — Dedicated team handled animal A.I. — Bears, wolves, deer move through the snow — You can get overwhelmed by enemies quickly — Link can keep multiple horses at a time — Affection / loyalty important with horses — Feed and take care of horses to raise their stats — Can call horses over to you, but horses need to be within a certain proximity to be called — Horses can be killed by enemies — Aonuma «wanted players to choose their own path», so no companion character in this game — Stamina meter encopasses sprinting, paragliding, climbing — Meter can be upgraded, but Nintendo won't say how — Different shields have different speeds and level of control for snowboarding — Can mine rocks which can be solid for rupees or used for crafting — Can place stamps to mark areas of interest — 100 of these symbols can be used on the map, including sword, shield, bow and arrow, pot, star, chest, skull, leaf, diamond — Every style of weapon has a unique set of animations and feel different — No invincible weapons in the game, Nintendo says — Zelda can get mad at you and scold you — Players can see the ending without seeing everything from the story — A certain element was added in the game to make for a more cohesive storyline — Most difficult Zelda game to make — Aonuma is still finding new things in the wOver 100 Shrines — You can find an item that identifies Shrines — Discover a Shrine for it to be a fast - travel point — Shrines also give a Spirit Orb — Trade in orbs for unknown items — Dedicated team handled animal A.I. — Bears, wolves, deer move through the snow — You can get overwhelmed by enemies quickly — Link can keep multiple horses at a time — Affection / loyalty important with horses — Feed and take care of horses to raise their stats — Can call horses over to you, but horses need to be within a certain proximity to be called — Horses can be killed by enemies — Aonuma «wanted players to choose their own path», so no companion character in this game — Stamina meter encopasses sprinting, paragliding, climbing — Meter can be upgraded, but Nintendo won't say how — Different shields have different speeds and level of control for snowboarding — Can mine rocks which can be solid for rupees or used for crafting — Can place stamps to mark areas of interest — 100 of these symbols can be used on the map, including sword, shield, bow and arrow, pot, star, chest, skull, leaf, diamond — Every style of weapon has a unique set of animations and feel different — No invincible weapons in the game, Nintendo says — Zelda can get mad at you and scold you — Players can see the ending without seeing everything from the story — A certain element was added in the game to make for a more cohesive storyline — Most difficult Zelda game to make — Aonuma is still finding new things in the wover to you, but horses need to be within a certain proximity to be called — Horses can be killed by enemies — Aonuma «wanted players to choose their own path», so no companion character in this game — Stamina meter encopasses sprinting, paragliding, climbing — Meter can be upgraded, but Nintendo won't say how — Different shields have different speeds and level of control for snowboarding — Can mine rocks which can be solid for rupees or used for crafting — Can place stamps to mark areas of interest — 100 of these symbols can be used on the map, including sword, shield, bow and arrow, pot, star, chest, skull, leaf, diamond — Every style of weapon has a unique set of animations and feel different — No invincible weapons in the game, Nintendo says — Zelda can get mad at you and scold you — Players can see the ending without seeing everything from the story — A certain element was added in the game to make for a more cohesive storyline — Most difficult Zelda game to make — Aonuma is still finding new things in Different shields have different speeds and level of control for snowboarding — Can mine rocks which can be solid for rupees or used for crafting — Can place stamps to mark areas of interest — 100 of these symbols can be used on the map, including sword, shield, bow and arrow, pot, star, chest, skull, leaf, diamond — Every style of weapon has a unique set of animations and feel different — No invincible weapons in the game, Nintendo says — Zelda can get mad at you and scold you — Players can see the ending without seeing everything from the story — A certain element was added in the game to make for a more cohesive storyline — Most difficult Zelda game to make — Aonuma is still finding new things in different speeds and level of control for snowboarding — Can mine rocks which can be solid for rupees or used for crafting — Can place stamps to mark areas of interest — 100 of these symbols can be used on the map, including sword, shield, bow and arrow, pot, star, chest, skull, leaf, diamond — Every style of weapon has a unique set of animations and feel different — No invincible weapons in the game, Nintendo says — Zelda can get mad at you and scold you — Players can see the ending without seeing everything from the story — A certain element was added in the game to make for a more cohesive storyline — Most difficult Zelda game to make — Aonuma is still finding new things in different — No invincible weapons in the game, Nintendo says — Zelda can get mad at you and scold you — Players can see the ending without seeing everything from the story — A certain element was added in the game to make for a more cohesive storyline — Most difficult Zelda game to make — Aonuma is still finding new things in the world

Sou at HotWhopper (linked above) points out that Watts can't explain why a heat sink or a reflective surface at a station would produce not just a different temperature but a different trend over time.

The trend lines for min temperatures on windy and calm time periods for 290 stations over the time period from 1950 - 2000, while intersecting the y axis at significantly different points (the windy trend lines always showing higher temperatures but the amount can depend on season), both trend at a 0.20 degree C per decade rate.

The emissions price must also rise at roughly the rate of interest (about five percent) over time (to equate the discounted marginal abatement costs at different points in time).

If there is a positive impact of regulatory reform, with ABSs being a part of that, then in performing this survey at different points in time (over 3 to 6 years, for example), we should see changes in the way that people respond to their problems.

Everyone's life insurance need will be different at different points in their lives, but the important thing to note is that your need will change over time.

Each life insurance policy ends at a different point, allowing you to effectively reduce your coverage over time while still locking in low rates while you're young and healthy.

Meanwhile, Dan Rayburn points out that Sandvine recently posted tests where an iPad and Apple TV on the same Comcast connection at the same time got different quality, because Netflix delivered service to the two devices over different connections.

Giovanni have practiced meditation daily (for the past 16 years, totaling over 7,000 hours at this point), read hundreds of books, tried several different practices, spent time on retreats with masters and instructors around the world, and nearly became a monk a couple of times.

The trauma may be the result of an event that occurred at any point in the individual's life, once or many times, or as one of many different traumatic events over time.

Because demand varies from region to region and the proportion of household income expected to be spent on housing also varies greatly from region to region, the Scout Vision Housing Affordability Index is best used to compare affordability in a region over time to assess overheated markets, rather than using the Index to compare different regions at one point in time to assess market overheating.