Sentences with phrase «at effects of mutations»

Not exact matches

The probability of a randomly selected mutation in a randomly selected gene having precisely that effect is quite low, so just as with the stones in the field, a positive finding is more likely than not to be spurious — unless the experiment is unbelievably successful at sorting the wheat from the chaff.

She did her master's degree research project at the Institute of Biochemistry and Biophysics (IBB), also in Warsaw, looking at the effect of genetic mutations on the function of an enzyme involved in the biosynthesis of heme, using Saccharomyces cerevisiae as a model organism.

Because it doesn't aim at reducing mosquitoes» health or ability to reproduce — reducing «fitness» in the Darwinian sense — a FREP1 inactivation would create less of an opportunity for mosquito mutations that resist its effects.

Whereas many researchers at the summit expressed confidence that off - target effects could be considerably reduced, Rudolf Jaenisch of MIT stressed a less - appreciated worry: When CRISPR repairs one copy of a disease gene, it sometimes introduces mutations into the healthy copy.

The speedup that Pande envisions would allow computers to simulate many proteins at once, or much more rapidly study the effects of different chemicals or mutations on proteins, says biological physicist José Onuchic of the University of California, San Diego, who was not involved in the project.

The new technique lets scientists analyze the effects of gene mutations at an unprecedented scale and speed, and at a fraction of the cost of traditional methods.

Overall, the pathologic complete response rate was lower among women with at least one PIK3CA mutation in their tumor compared with women without a PIK3CA mutation, but the effect was only significant among the group of women with HER2 - and hormone receptor - positive breast cancer.

Researchers at the University of Oxford have discovered that a cellular mechanism preferentially protects plant genes from the damaging effects of mutation.

Scientists at the University of Dundee have identified the effects of a mutation that gives rise to a form of intellectual disability.

Final confirmation would depend on studies of the effects of the mutation of the expression of gene products at the levels of RNA and protein.

The exome sequences of 1,535 Kronos and 1,200 Cadenza mutants have been re-sequenced using Illumina next - generation sequencing, the raw data aligned to the IWGSC Chinese Spring chromosome arm survey sequence, mutations identified, and their effects predicted based on the protein annotation available at the Ensembl Plants archive site.

Shokat believes the new results may make researchers go back and look at the assumptions they've made in interpreting the effects of mutations in other G - proteins» «off» switches.

We have re-sequenced the exome of 1,535 Kronos and 1,200 Cadenza mutants using Illumina next - generation sequencing, aligned this raw data to the IWGSC Chinese Spring chromosome arm survey sequence, identified mutations, and predicted their effects based on the protein annotation available at Ensembl Plants.

Researchers at Whitehead Institute have now uncovered a role for the protein - folding chaperone HSP90 in humans, not only as a modifier of the effects of mutations, but as a mediator of the impact of the environment on the function of mutant proteins.

This study does not support the idea of exercise as a strategy to raise brain progranulin levels in symptomatic patients with FTD due to GRN mutations, as we observed no effects on progranulin levels in Grn + / − mice at 4 — 8 months of age, the age range in which these mice begin to develop abnormal behavior and neuronal dysfunction (Filiano et al., 2013).

The effect of the LGR4 mutation on many other conditions was further investigated taking advantage of a large number of human diseases and other traits that are available at deCODE.

According to Lewis Cantley, director of the Cancer Center at Beth Israel Deaconess Medical Center at Harvard Medical School, as much as 80 percent of all cancers are «driven by either mutations or environmental factors that work to enhance or mimic the effect of insulin on the incipient tumor cells,» Gary Taubes reports, vii adding:

Since both types of HSF4 mutations have profound deleterious effects on vision when two copies of the mutation are present, it is recommended that at least one member of a breeding pair has been DNA tested as Normal / Clear of the mutation.