Another issue is that mucus is essential for immunity
at epithelial surfaces, and glycosylation is essential for the integrity of cellular junctions and tissue barriers such as the intestinal and blood - brain barriers.
IL17 is a cytokine with roles in anti-bacterial and anti-fungal defense that is made abundantly by effector T cells
at epithelial surfaces (Littman and Rudensky, 2010).
That is, the experiments showed that the potentiator cancelled out the intended effect of having a corrected CFTR protein
at the epithelial surface.
Not exact matches
A. Microscopic view of the respiratory mucosa consisting of ciliated
epithelial cells (i.e. presence of cilia
at their apical
surface).