Sentences with phrase «at gene expression»

«The extra information we get from looking at gene expression could help us make more informed decisions about how harmful a toxicant is, and it could give regulators a new direction that we should be pursuing in monitoring water quality.

This was tested in vitro, and the researchers also looked at the gene expression of certain sugars, IGF - 1, and IGF1R.

This finding was striking because the researchers showed that the changes were not reflected at the gene expression level, underscoring the importance of proteome profiling.

For custom gene expression projects the Genomics Core has a platform that uses sets of human and mouse custom arrays whose probe content is aimed at gene expression studies in the areas of cancer, immunology and other complex diseases.

«When we looked at gene expression, we found fairly small changes in 65 million years of the macaque, orangutan, and chimpanzee evolution,» said study author Yoav Gilad, PhD, assistant professor of human genetics at the University of Chicago, «followed by rapid change, along the five million years of the human lineage, that was concentrated on these specific groups of genes.

«Looking at gene expression, the ketogenic diet suppressed the longevity - related TOR pathway and insulin signaling and up - regulated the fasting - related transcription factor PPAR - alpha, a master regulator that helps the body more efficiently metabolize fat.»

The authors looked at gene expression in a panel of 50 ERBB2 (Her2) positive breast tumors and found that this pattern held up: DNA hypomethylation is associated with decreased gene expression in breast cancer.

In studying the human placenta, researchers looked at gene expression: the process by which a gene's DNA sequence is converted into cellular proteins.

Scientists in both teams looked at the gene expression associated with each protein.

Both teams, in addition to looking at gene expression, found that the area in the birds» retinas where Cry4 is located receives a lot of light.

By looking at the gene expression profile in single cells, the researchers were able to identify previously unknown transient states that typified the progression from precursor to more - specialized cells.

We also looked at gene expression in B - cell lymphomas, comparing samples from individuals with risk or non-risk haplotypes.

MIAME - compliant supplementary information is included online at Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo/index.cgi; GSE9173 and GSE9175).

Furthermore, GNC and GNL act, at the gene expression level, in an additive manner with the GOLDEN2 - LIKE1 (GLK1) and GLK2 transcription factor genes, which are also important for proper chlorophyll accumulation.

«When we looked at gene expression, we found fairly small changes in 65 million years of the macaque, orangutan and chimpanzee evolution,» Gilad explains.»

The MD Anderson team also is looking at gene expression, mutations and immune profiling to identify potential differences in melanoma in obese and non-obese patients and developing preclinical models.

«By looking comprehensively at gene expression within cells, we can now spot numerous important differences in complex tissues like the brain that are invisible today,» said George Church, Ph.D., a Core Faculty member at the Wyss Institute and Professor of Genetics at Harvard Medical School.

Another important pathway, related to the p53 gene (a protector of the genome), is also relevant when we looked at gene expression in the skin of acne twins compared to twin controls.»

Finally they looked at gene expression in autopsied brains of individuals with Rett.

The researchers also looked at the gene expression of skin cells from people with psoriasis and found decreased expression of the genes involved in pigmentation signaling, correlated with increased amounts of IL - 17 and TNF.

When his team looked at gene expression changes in the mice, then applied them to humans with early stage cancer, the results revealed a breakdown of which patients have a high or low chance of survival.

Then — noting the side of the colon that the tumor originated from — the researchers look at gene expression.

Prof. Khatri and his team studied the way the immune system responds to infection by looking at gene expression — which genes are active and which are not — and whether there are differences in patients with malaria compared to other infectious diseases.

According to Izpisúa Belmonte, who is also a professor at the gene expression laboratories of the Salk Institute for Biological Studies in San Diego, California, CMRB aims to become «a research centre of excellence in south Europe in the line of world - recognized institutions such as the Salk or the Whitehead institutes, where both pre - and postdoctoral researchers receive multidisciplinary training of the highest quality» in stem cell biology and cell regeneration.

The team also looked at gene expression before and after exposure and identified 335 genes whose variation in expression correlated with caspase activity.

«We were starting to understand a lot about circuits and cells, and we had the tools to look at gene expression in different kinds of cells?

Not exact matches

The idea that at least some of the non-coding DNA might have latent functionality beyond basic gene expression has been around for a couple of decades.

As a Howard Hughes Medical Institute investigator and biochemistry professor at Stanford, Pat led a team that developed the first methods for analyzing, visualizing and interpreting global gene expression programs.

Because epigenetics is the real driver of your health status, and diet plays a major role in gene expression (aka epigenetics), at least in this post's animal study!

He attended UC Berkley and Sonoma State University where he studied Cell Biology and worked at the USDA Plant Gene Expression Center.

Moshe Szyf, a molecular biologist at McGill University, discusses the way parental licking and grooming affects the expression of certain genes in rat pups.

Citation: Lemay DG, Ballard OA, Hughes MA, Morrow AL, Horseman ND, Nommsen - Rivers LA (2013) RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation.

The resulting transcriptional profiles cluster not by postpartum day, but by milk Na: K ratio, indicating that women sampled during similar postpartum time frames could be at markedly different stages of gene expression.

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

Scientists at Southern Methodist University, led by Professor and Chair of Biological Sciences Santosh D'Mello, have used RNA - Seq to conduct transcriptome profiling of gene expression changes in dying neurons.

Thus RNA self - splicing can occur at a rate sufficient to support gene expression in a prokaryote, despite the likely presence of ribosomes on the nascent RNA.

By identifying gene expression signatures common to sight, touch and hearing, neuroscientists at the University of Geneva (UNIGE), Switzerland, discovered a sensory «lingua franca» which facilitates the brain's interpretation and integration of sensory input.

DNA methylation is a mechanism cells use to control gene expression at the epigenetic level.

In an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replication.

P. Read Montague, professor of neuroscience at Baylor College of Medicine, says, «In a sense, every measurement that you make in neuroscience — electrophysiological, optical, gene expression, and so on — is imaging.

Now, new research suggests changes at the epigenetic level — specifically alterations in proteins that affect gene expression, rather than genetic mutations — could be driving childhood ependymomas.

Sankar Ghosh, professor of immunobiology at Yale University, explores the regulation of gene expression in developing and differentiating lymphocytes.

The Epstein - Barr virus, which infects some 90 % of Americans, may cause changes in gene expression that dramatically increase a person's chance of getting lupus and six other autoimmune disorders, a new study by Harley, now a rheumatologist at the Cincinnati Children's Hospital Medical Center in Ohio, and colleagues shows.

Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab - grown human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Only a decade later was it confirmed to bind to DNA and turn on the expression of other genes aimed at healing cell damage.

At a 0.2 - millimolar sucralose dose similar to the concentration found in the blood of people with high consumption of low - calorie sweeteners — equal to four cans of diet soda per day — the researchers said they observed increased expression of genes that are markers of fat production and inflammation.

«It is exciting to find a correlation between brain circuitry and gene expression by combining high quality data from these two large - scale projects,» says David Van Essen, Ph.D., professor at Washington University in St. Louis and a leader of the Human Connectome Project.

They found that gene expression is different at 209 sites in chronically lonely people and that many of those changes fit a pattern of elevated immune activation, inflammation, and depressed response to infection.

Investigators at Duke University, led by Erica Davis, PhD, a co-senior author of the report, blocked the gene's expression in zebrafish, which resulted in abnormal facial cartilage, smaller eyes and structural abnormalities of neurons involved in the development of reproductive organs.