Kar P, Laight D, Rooprai HK, Shaw KM, Cummings M. Effects of grape seed extract in Type 2 diabetic
subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity.
PREDIMED, one of the largest interventional dietary trials, randomized more than 7,000 men and women
at high cardiovascular risk into different diet groups and followed them for years.
Back in 2013 a study was published in the New England Journal of Medicine titled «Primary Prevention of Cardiovascular Disease with a Mediterranean Diet» stating through results of this study, which included over 7000 participants per group — «among
persons at high cardiovascular risk, a Mediterranean diet supplemented with extra virgin olive oil or nuts reduced * the incidence of major cardiovascular events.»
All participants were
at high cardiovascular risk or had type 2 diabetes, and more than 90 % were overweight or obese.
In a multicenter trial in Spain, we randomly assigned participants who were
at high cardiovascular risk, but with no cardiovascular disease at enrollment, to one of three diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat).
Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipoprotein subfractions to a less atherogenic pattern in subjects
at high cardiovascular risk.
Separate research showed that eating just one ounce of walnuts a day may decrease cardiovascular risk, and among
those at high cardiovascular risk, increased frequency of nut consumption significantly lowers the risk of death.
Diabetic Medicine, May 2009, 26 (5): 526ï ¿ 1/2 531, «Effects of grape seed extract in Type 2 diabetic subjects
at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity»