Rather than looking at what distinguished two forms of retinitis pigmentosa, or RP, a progressive blinding disease, they looked for what they had in common: specifically, what genes were expressed
at the later stages of disease.
However, the researchers found that stopping neurogenesis before the development of seizures had a long - lasting effect, suppressing chronic seizure frequency for nearly one year, even
at a late stage of the disease.
«If we could perhaps modulate these pathways and prolong survival of photoreceptor cells, we might be able to delay any further degeneration even when intervening
at these later stages of disease.»
Breast cancer cells that spread to other parts of the body break off and leave the primary tumour
at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.
Since many of those patients are likely to be given the drugs
at later stages of their disease, much of this cost is likely unavoidable, even if it gets delayed.
This poor prognosis is partially due to the fact that most patients are not diagnosed until they are already
at a late stage of the disease.
Not exact matches
The detection
of melanoma
at its most curable
stages can result in decades
of high - quality life saved, versus the treatment
of this terrible
disease at late stages, which offers several months
of life extension,
at best.»
Radiologists came from across the hospital to peer
at the results, disbelieving: A perfectly healthy 21 - year - old nonsmoker with no family history
of the
disease had lung cancer, which three days
later would be diagnosed as
stage IV, the most advanced form.
«We wanted to identify some potential therapeutic targets that are common not just to one but to multiple forms
of retinitis pigmentosa
at late -
stage disease, when it is more likely to be clinically diagnosed in a patient population.»
A drug used to treat men with
late -
stage prostate cancer proved effective in stemming progression
of the
disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute
at Oregon Health & Science University (OHSU).
Pancreatic cancer is a particularly devastating
disease because
of the difficulty
of identifying it
at an early
stage, and the difficulty
of treating it when discovered
at a
late stage.
«Early
stage disease is curable,» adds co-author Bernadette Cracchiolo, director
of gynecologic oncology
at the school, «but
late stage and recurrent
disease have limited treatment options.
In some cases,
late onset
of the
disease can also occur if the infection is not detected
at an early
stage or if it is not treated with antibiotics.
«The dBET1 and the dFKBP12 compounds are presently in a
late stage of lead optimization for therapeutic development in both cancer and non-malignant
diseases,» says Prem Das, PhD, chief research business development officer
at Dana - Farber.
here is epidemiological evidence that links type B coxsackie virus (CVB) infection with heart
disease, and research published on July 31st in PLOS Pathogens now suggests a mechanism by which early infection impairs the heart's ability to tolerate stress
at later stages of life.
What is the
latest biological
stage of Alzheimer's
disease at which secretase inhibition slows progression?
The goal was to investigate the ability
of J147 to rescue cognitive impairment
at a
late stage in the
disease as an indicator
of its potential to rescue cognitive impairment in humans with AD.
I've been working for the last 5 years in trying to bring image resolution to «in vivo» imaging comparable to microscopy because right now we believe there is a disconnect between the clinical imaging that looks
at very microscopic features
of the eye that are informative
of the
disease but usually
at very
late stages and the exquisite work that molecular biologists are doing.
Lung cancer is the leading cause
of cancer mortality worldwide, suffering from a
late stage of disease at the time
of diagnosis and a paucity
of effective therapeutic strategies to treat advanced tumours.
«Much to our surprise, the trial showed that patients receiving standard therapy compared to those receiving cetuximab with standard therapy had no difference in outcomes,» said study author Dr. Steven Alberts, a professor
of oncology
at the Mayo Clinic College
of Medicine in Rochester, Minn. «It also indicates that
disease in earlier
stages may be different than
diseases in
later stages.»
While different types
of cancers have different survival rates, in general, it can be challenging to treat the
disease if it was detected
at this
late stage.
This is despite evidence the drug doesn't work that well,
at least in
later stages of the
disease.
If that's the case, then owners
of cats with mesothelioma may be
at risk for developing the
disease at some
later stage.
However, over weeks, months or even years, when the cat is in
later stages of the
disease (secondary viremia), the infected cat's health may deteriorate to the point
at which he or she has recurrent illness punctuated with phases
of wellness.
Because
of their location, oral malignant tumors are often detected
late in the course
of the
disease process and have commonly progressed to
Stage II
at the time
of diagnosis.
However, due to the fact that the
disease is typically diagnosed
at a
late stage, treatment rarely stops the progression
of the
disease, and regression is also untypical.