Age
at menarche and weight concerns in relation to smoking trajectory and dependence among adolescent girls enrolled in a smoking cessation trial
The mean age
at menarche in this sample was13 years (range, 8.5 - 15 years), and 46 % of the adolescent boys had their growth spurt from ages 13 to 15 years.
Adjusted for age, education, family history of breast cancer, history of benign breast disease, parity, age at first birth, age
at menarche, age at menopause, oral contraceptive use, postmenopausal hormone use, BMI, physical activity, smoking, calcium supplement use, and alcohol intake.
Adding other factors, such as assay batch, family history of breast cancer, age
at menarche, breastfeeding, physical activity, childhood BMI, smoking, drinking status, and intake of fat and fiber into the multivariable model did not change the result appreciably, but reduced the precision.
Breast cancer is associated with dietary fat (which is associated with animal protein intake) and inversely with age
at menarche (women who reach puberty at younger ages have a greater risk of breast cancer).
Additionally, «Having an earlier age
at menarche has been associated with elevated blood pressure and glucose intolerance, increased body fat in early adulthood, or obesity in adulthood, all of which could explain the possible link between the age
at menarche and risk of mortality outcomes later in life.»
«These results highlight the possibility that hormonal mechanisms may explain the link between parity [childbearing], breast - feeding, [oral contraceptive] use, and a later age
at menarche with a lower mortality risk.
From the data, they found «childbirth, breast - feeding, oral contraceptive use, and a later age
at menarche were associated with better health outcomes.»
Factors examined as potential confounders or effect modifiers included age (at breast cancer diagnosis for cases, at time of study enrollment for controls), age at first birth, number of children, birth of a son, history of breastfeeding, miscarriage, abortion, oral contraceptive use, smoking status, age
at menarche and number of cell equivalents tested for detection of FMc.
Genome - wide association study identifies sequence variants on 6q21 associated with age
at menarche.
The paper, «Genome - wide association study identifies sequence variants on 6q21 associated with age
at menarche,» is published in the online edition of Nature Genetics, at www.nature.com/ng, and will be published in an upcoming print edition of the journal.
Reykjavik, ICELAND, May 17, 2009 — In a paper published today in the online edition of Nature Genetics, scientists from deCODE genetics (Nasdaq: DCGN) and academic colleagues from Iceland, Denmark and the Netherlands present the discovery of single letter variations in the sequence of the human genome (SNPs) that influence the age of girls
at menarche, the first menstrual period.
Age
at menarche predicts age at onset of major affective and anxiety disorders Tondo L, Pinna M, Serra G, De Chiara L, Baldessarini RJ.
Both BRCA1 and BRCA2 mutation carriers had a median parity of 2.0 live births and age
at menarche of 13 years.
«This highlights the need for a greater understanding of the cultural and regional variations in the effect of age
at menarche on age at marriage both within and between countries.»
The researchers also studied the link between age
at menarche and early marriage.
His team, as well as independent groups based in the UK, the US and Iceland, uncovered this gene's role by comparing genome - wide scans of thousands of women with their age
at menarche.
Detailed information on women's reproductive factors was also collected, such as age
at menarche, the number of pregnancies, abortions, live births, and the total duration of any breastfeeding for each live birth.
Not exact matches
All four teams focused their hunts on gene variations found in
at least 10 per cent of the population, while Stefánsson thinks that rarer variants may play a more significant role in
menarche.
This helps explain why women who go through
menarche later are taller than women who have their first period
at a young age, says Uitterlinden.
Just how LIN28B might affect
menarche isn't clear, says Ken Ong, a paediatrician
at the Medical Research Council Epidemiology Unit in Cambridge, UK, who led another team.
For instance, one study found that Icelandic girls with two genetic letter Ts
at a spot near LIN28B experience
menarche 2.4 months earlier, on average, than girls with two Cs
at that site.
That's according to Misao Fukuda
at the M&K Health Institute in Hyogo, Japan, and colleagues, who found subtle differences in sex ratios of children depending on when a mother entered
menarche.
In rural Malawi, 55 percent of those who had their first period before age 14 had sex before the age of 16, compared with 27 percent of those with
menarche at age 14 to 15, and only 4 percent of those with
menarche at age 16 or older.
«Despite possible similarities in the relationship between early
menarche and sexual and reproductive health in low -, middle - and high - income countries, the factors associated with early
menarche and early marriage may differ across ethnic groups within the same country,» noted Mobolaji Ibitoye, MPH, DrPH candidate in the Department of Sociomedical Sciences
at the Mailman School and lead author.
With
menarche at 17 in Sweden only a century ago, and with the first baby having a lower chance of survival, I'd guess that the average surviving children were mostly born when the mother was between 20 and 30.
The association between timing of
menarche and depressive symptoms
at 10.5, 13 and 14 years was examined within a structural equation model.