Sentences with phrase «at minor allele»
Not so long ago, there was a hope in the research community that common genetic variation, i.e. variants present at minor allele frequencies > 5 % in human populations, might explain most or all of the heritability of common complex disease.
http://massgenomics.org/ Not exact matches
To understand how the different alleles influence the immune response to vaccination, the researchers next looked in more detail at immune cells from 47 of the patients (34 had two major T alleles, and 13 had at least one minor G allele).
We tested the hypothesis that the frequency of the minor Ser482 allele at the PPARGC1A locus is lower in World - class Spanish male endurance athletes (cases)[n = 104; mean (SD) age: 26.8 (3.8) yr] than in unfit United Kingdom (UK) Caucasian male controls [n = 100; mean (SD) age: 49.3 (8.1) yr].
They're not all rare variants, either: 86 million variants are classified as common (G5, G5A, or COMMON), with minor allele frequencies > 1 % in at least one population.