Importantly, the research team also looked
at optic nerves of the central nervous system, which are damaged in glaucoma, and found similar protective effects from the loss of Phr1.
«We looked
at the optic nerve and saw normal myelination,» Mukherjee said, referring to the fatty white sheathing wrapped around axons, the nerve fibers that allow information transmission over distances to proceed efficiently and rapidly.
Consistent with the presence of donor - derived RGCs, YFP - labeled processes were detected exiting the eye
at the optic nerve head (Figures 4E, 5B, and S2B).
We observed YFP - labeled processes exiting the induced eye
at the optic nerve head that followed the expected trajectory of RGC axons to their tectal targets (Figure 4E).
Of course, visual field testing, looking
at the optic nerve, optic nerve atrophy, nerve fiber layer thinning, using optical coherence tomography, but the real question is can we back that up significantly and be able to tell whether the patient sitting right there in the chair is in trouble?
The pattern of RGC loss in patients as well as information obtained from laboratory research all point to the fact that an important site of pathology occurs
at the optic nerve head, a region where the axonal cell processes of RGCs exit the eye on their way to the visual centers of the brain.
We have some biomarkers for glaucoma that tell us whether patients have the disease, like visual field tests or imaging, just letting your doctor look
at the optic nerve in the back of the eye is a biomarker for whether you have glaucoma and, at least at a gross level, whether it's getting worse.
Not exact matches
Your baby's senses are becoming better by the day, and studies show that babies
at this stage respond to light and touch, conveying the fact that the
optic nerve is up and running.
Subject also suffers apparent
optic nerve damage from SXSW - hottie - ogling (one can't look too long
at the sun without consequences, after all).
Fourteen patients exhibited retinal and / or
optic nerve damage and had neuroimaging or neurological abnormalities detected
at birth.
Mice with this eye disease, which damages the
optic nerve and causes vision loss, have higher levels of the immune molecule, which accumulates
at retinal synapses before the neurons die.
To investigate these questions, Daniel Dilks and his colleagues
at the Massachusetts Institute of Technology took advantage of the blind spots that occur naturally in our eyes where the
optic nerve exits the retina.
At this point, there is no effective treatment for TON and the mechanisms of the
optic nerve cell death have been largely unclear.
«Our work could lead not only to a better understanding of the biology of the
optic nerve, but also to a cell - based human model that could be used to discover drugs that stop or treat blinding conditions,» says study leader Donald Zack, M.D., Ph.D., the Guerrieri Family Professor of Ophthalmology
at the Johns Hopkins University School of Medicine.
The oldest known drawing of the nervous system shows a large nose
at the bottom, eyes on either side, and a hollow
optic nerve that flows out of each one towards the back of the brain.
Those tests don't give us the details we need to understand the nature of the pathology
at the cellular level, so we modeled the disease to perform a systematic analysis of the
optic nerve, from its origin in the eyes to termination in the brain.»
«In a mouse, the
optic nerve looks normal
at birth, which is the equivalent of the third trimester of neonatal human development,» said Fox.
We had to develop a model to examine the
optic nerve at different points in time.»
«Although clinicians have known about
optic nerve hypoplasia for some time, the nature of the pathology was not clearly understood,» said Konark Mukherjee, an assistant professor
at the Virginia Tech Carilion Research Institute.
Scientists
at the Virginia Tech Carilion Research Institute (VTCRI) have revealed the pathology of cells and structures stricken by
optic nerve hypoplasia, a leading cause of childhood blindness in developed nations.
«We used a mouse model of the KPro to, first of all, identify the inflammatory factors that cause damage to the eye, and then we also quantified the amount of
nerve cell death in the back of the eye that mediates the
optic neuropathy, and, lastly, we looked
at blocking these factors with antibodies,» said Reza Dana, M.D., M.Sc., MPH, Director of the Cornea and Refractive Surgery Service
at Massachusetts Eye and Ear and the Claes H. Dohlman Professor of Ophthalmology
at Harvard Medical School.
«The brain
at rest» is actually a hive of activity and what it's doing is trying to sort out information that comes in; I mean this is another, another thing that made Marcus Raichle curious about this, is we know, for instance, that six million bits of data go flowing in through your
optic nerve from the environment around you, and then only 10,000 of those bits actually get to the brain's visual processing area and only a few hundred of those are involved in consciousness, and you know, the conscious processing associated with that visual activity.
LCA affect the retina, the thin layer of tissue
at the back of the eye that detects light as well as differentiates colors and communicates the information to the brain via the
optic nerve.
In particular, our two world - class lead engineering collaborators Dr. Alfredo Dubra and Dr. Vivek Srinivasan have been building the actual instruments that will be used to peer into patients» eyes and image their retinas and
optic nerves at a level of detail never before seen.
Dr. Levin's lab is investigating a new class of drugs that are highly effective
at keeping RGCs alive when the
optic nerve is damaged by glaucoma.
They decay in the retina not just
at the site of injury in the
optic nerve, but back in the retina where we can be imagining them.
We seek to determine whether a particular type of imaging, known as «polarization - sensitive» imaging, is capable of reporting on the integrity of sub-microscopic structures within
optic nerve fibers
at an early stage of damage from glaucoma, preceding their complete degeneration and loss from the eye.
We seek in this proposal to determine whether a particular type of imaging is capable of assessing and reporting on the integrity of sub-microscopic structures within
optic nerve fibers
at an early stage of damage preceding their complete degeneration and loss from the eye.
Another example, this is something that's going on in my laboratory, is that we're starting to look
at protein and fat deposits in the retina and the
optic nerve that we hopefully can measure in blood serum that tell us that the disease is progressing early on.
Initially, there are usually no symptoms, but as eye pressure gradually builds,
at some point the
optic nerve is impaired and peripheral vision is lost.
Right now all therapy for glaucoma is directed
at lowering eye pressure, but the idea that we could develop therapies and test them in people that really target the retinal ganglion cells and the axon fibers going into the
optic nerve — that, I think, is the most exciting new frontier for the premise of restoring vision and protecting vision in glaucoma.
It helps the eyes by reducing eye twitching and spasms, and also protects the
optic nerve and tissues
at the back of the eye.
Studies suggest that melatonin levels are higher during the night when the circadian rhythm (body clock) sends signals to the
optic nerve that the body is
at rest (darkness).
hello I am Michael ween I was born I had a brain ingery a birth strock and almost died from the bleeding and I am blind in my tight eye the
optic nerve got pinched
at birth I am not here often but you can email me
Something of a town hero, Travis lost his sight completely
at the height of his football career due to an infection of the
optic nerve.
The point is that the functionality of the most important hardware — our eyes,
optic nerves and brain — and the most important software — Homo sapiens V. 1.0 — has been around for
at least 140,000 years, and will take longer to evolve than anything that can happen in my or Michael's lifetimes.
It's an exciting time to have genetically modified
optic nerves made for staring
at computer screens.
Treatment is aimed
at maintaining the pressure in a comfortable range and limiting damage to the retina and
optic nerve.
When a defect
at this level of the eye is minor, a patient remains visual; alternatively, a more serious defect of the
optic nerve may be the cause of complete blindness.
The pupillary response comes from the second and third cranial
nerve with the
nerves actually crossing to the opposite side
at the
optic chiasm.
The centre of the circle is F. (G) point
at which the
optic nerve deviates into the canal (inset).
MOCA ANNUAL
OPTIC NERVE FILM FESTIVAL EXPANDED TO INCLUDE NATIONAL ARTISTS Screening: Saturday, August 27 at 7 pm and 9 pm North Miami, FL - In recognition of its 15th anniversary, the Museum of Contemporary Art, North Miami has broadened the scope of its annual Optic Nerve Film Festival featuri
NERVE FILM FESTIVAL EXPANDED TO INCLUDE NATIONAL ARTISTS Screening: Saturday, August 27
at 7 pm and 9 pm North Miami, FL - In recognition of its 15th anniversary, the Museum of Contemporary Art, North Miami has broadened the scope of its annual
Optic Nerve Film Festival featuri
Nerve Film Festival featuring...
Did you wear sunglasses to avoid
optic nerve damage
at that blinding flash of the obvious there, James?
Structures
at the back of the eye include the retina and
optic nerve.