Sentences with phrase «at osteocalcin»

Not exact matches

«The addition of osteocalcin as a metabolic regulator may one day lead to novel therapies, but we need to understand much better how it works and how it fits into physiology before such therapies can be attempted in humans,» says endocrinologist Mitch Lazar, director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania.

The researcher at the Montreal Clinical Research Institute (IRCM) and professor at Université de Montréal's Faculty of Medicine has spent the last decade studying a hormone called osteocalcin.

In 2013, a team led by Gerard Karsenty, the Paul A. Marks Professor and chair of the department of genetics and development at Columbia University Medical Center, showed that mice lacking osteocalcin have major cognitive defects.

* Oddly enough, however, the experiments with fresh pancreatic islets and fat cells taken from the mice suggested that the positive effects of uncarboxylated osteocalcin on insulin only occurred at concentrations extremely low compared to those of undercarboxylated osteocalcin normally present in mice, while the effects on adiponectin and energy expenditure only occurred at normal to high concentrations.

The Opotowski team, which found that low vitamin A levels had as great an effect lowering BMD as did high vitamin A levels, suggested that vitamin A deficiency may contribute to increased fracture risk by allowing bone matrix to grow faster than it can be mineralized.12 Indeed, although the net effect of vitamin A is to stimulate osteoclasts and slow the growth of osteoblasts, vitamin A also causes osteoblasts to secrete a variety of enzymes and other proteins that are important to bone mineralization, including osteocalcin, which is a protein that plays a direct role in attracting and binding calcium within the bone matrix.6 By slowing the growth of the matrix but increasing the rate at which it is mineralized, adequate vitamin A helps to ensure sufficient bone density.