Sentences with phrase «at plasma membrane»

Time - lapse superresolution imaging of clathrin dynamics at the plasma membrane using dSTORM (ATTO655).

In differentiated adipocytes GFP - tagged ARL15 localized predominantly to the Golgi with lower levels detected at the plasma membrane and intracellular vesicles, suggesting involvement in intracellular trafficking.

A part of the explanation might be the changes in plasma membrane lipid composition that accompany the secretion process and lead to changes in signaling properties of the receptors present at the plasma membrane (IGF - 1R, IR).

Palmitoylation at Cys - 416 is important for recruitment at both plasma membrane and lipid rafts and association with G protein alpha subunits.

We now aim at unraveling molecular and functional links between endocytic sorting at the plasma membrane and retrograde sorting on early endosomes.

A host of endocytic processes has been described at the plasma membrane of eukaryotic cells.

«A whole generation of cancer investigators, including me, has been taught that PTEN performs its crucial role at the plasma membrane, which is what separates the inside of cells from the outside environment» Trotman explains.

It is then possible that we have failed to detect low levels of Aβ or APP at plasma membrane locations.

Platelet - activating factor - induced clathrin - mediated endocytosis requires β - arrestin - 1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.

Assembly of the PtdIns 4 - kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3.

A Highlights from MBoC Selection: Compartmentalized Cyclic Adenosine 3 ′, 5 ′ - Monophosphate at the Plasma Membrane Clusters PDE3A and Cystic Fibrosis Transmembrane Conductance Regulator into Microdomains.

The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane.

Altered cGMP Dynamics at the Plasma Membrane Contribute to Diarrhea in Ulcerative Colitis.

Compartmentalized cyclic adenosine 3 ′, 5 ′ - monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains.

«We found that receptor and G proteins meet and interact at specific locations at the plasma membrane, which we term «hot spots».

These cells showed reduced levels of PIP2 at the plasma membrane and thus failed to recruit Gag to form viral assembly sites.

Thus, distribution and mobility of specific lipid species at the plasma membrane appears to precisely regulated by membrane - associated proteins.

Not exact matches

In the worm, only harmless concentrations of hydrogen peroxide are generated and this process occurs at different rates at both sides of the plasma membrane.

An isoform of amphiphysin 2 concentrated at T - tubules induced tubular plasma membrane invaginations when expressed in nonmuscle cells.

In the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systems.

Here we used this approach to show that newly synthesized connexin43 was transported predominantly in 100 - to 150 - nanometer vesicles to the plasma membrane and incorporated at the periphery of existing gap junctions, whereas older connexins were removed from the center of the plaques into pleiomorphic vesicles of widely varying sizes.

New HIV - 1 particles assemble at specialized sites in the plasma membrane that are enriched in PIP2, a phospholipid component of the membrane that recruits a viral protein called Pr55Gag (Gag) that directs HIV - 1 assembly.

«Both the neuronal and average human membrane models — arguably the most compositionally complex plasma membrane lipid models to date — showed non-ideal lateral lipid mixing at different length and time scales, demonstrating the inherent complexity of biological membranes.»

A research team led by Prof. Dr. Prasad Shastri at the University of Freiburg has shown that the stiffness of the cancer cell plasma membrane affects how nanoparticles are internalized, and this process can be enhanced when the cell plasma membrane stiffness is increased.

Muscle contraction is initiated when action potentials fired at the end - plate of the muscle cells propagate throughout the plasma membrane and trigger a conformational change of the voltage-gated CAV1.1 Ca2 + + channel (also called dihydropyridine receptor, DHPR).

With Cell Painting, a technique developed at the Broad, researchers tag eight cellular components and organelles (actin, cytoplasmic RNA, endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, nucleolus, and the plasma membrane) with fluorescent dyes.

This morphology prevents at least some FB - MO proteins from diffusing into the plasma membrane [44], and it may prevent diffusion of PEEL - 1 as well.

Aβ is believed to penetrate neuronal plasma membranes, where it leads to lipid peroxidation.10 It has also been implicated in deactivating a subunit of the pyruvate dehydrogenase complex, thereby inhibiting conversion of pyruvate to acetyl CoA and the eventual production of cellular energy as ATP.32 Another way Aβ affects glucose metabolism in the brain is that fragments of Aβ disrupt insulin signaling by binding to neuronal synapses, which alters their shape and function.15, 38 Insulin receptors are abundant at synapses, so if the integrity of the synapse itself has been compromised, the receptors won't function effectively.