«We looked
at regulations of genes, rather than genes themselves, and whether the gene is expressed in certain tissues or how much the gene is expressed there.
Not exact matches
Dean Hamer, the chief
of gene structure and
regulation at the National Cancer Institute's Laboratory
of Biochemistry, wrote recently in Scientific American about his vision
of a not - too - distant future in which an imaginary couple, Syd and Kayla, got to tweak the emotional makeup
of their fetus.
Sankar Ghosh, professor
of immunobiology
at Yale University, explores the
regulation of gene expression in developing and differentiating lymphocytes.
Today, a team
of researchers from the University
of Geneva (UNIGE), Switzerland, led by Emmanouil Dermitzakis, Louis - Jeantet Professor
at the Faculty
of Medicine, reveals that this is not always the case and that DNA methylation may play both a passive and active role in
gene regulation.
The whole point
of a
gene drive is to disperse in the wild, but government
regulations are designed to keep genetic engineering out
of wild organisms, says Zach Adelman, a molecular biologist
at Virginia Tech in Blacksburg.
Research coordinated by Osaka University has now shown that the nuclear protein complex cohesin must be expressed
at sufficient levels in the early mouse brain to control
gene regulation and allow development
of healthy neuronal networks and behavioral characteristics.
Cavalli and his team
at the Institute
of Human Genetics (University
of Montpellier / CNRS) are the first to show that
regulation of gene position can lead to transgenerational inheritance.
Specifically, Toni Gabaldón's group
at the Centre for Genomic
Regulation in Barcelona has compared the Iberian lynx genome with those
of other species, attempting to identify
genes that have lost their function because they have remained isolated and the existence
of a small population
of specimens
of this species.
«This step in the UK will stimulate debate on legal
regulation of germline
gene editing in clinical settings,» says Tetsuya Ishii, a bioethicist
at Hokkaido University in Sapporo, Japan, who notes that some countries do not explicitly prohibit reproductive applications.
A new function now described for the protein dDsk2 by the team headed by Ferran Azorín, group leader
at the Institute for Research in Biomedicine (IRB Barcelona) and CSIC research professor, links ubiquitin receptors for the first time with the
regulation of gene expression.
At the nucleic acid level, understanding the precise
regulation of genes through analysis
of gene expression data will be
of utmost importance.
«Along with previous examples
of small RNA exchange between fungi and plants, our results imply that this cross-species
gene regulation may be more widespread in other plant - parasite interactions,» said Michael J. Axtell, professor
of biology
at Penn State and an author
of the paper.
Should there be
regulations that compel a physician or the parents to alert siblings and others who may be
at high risk
of harbouring the
gene?
«This study sheds light on this paradox and uncovers a way by which the stress hormone could prevent diseases,
at least psychologically, through
regulation of the Ppm1f
gene» he adds.
«We concluded that RAC1 regulates lung branching morphogenesis, in part through the so - called canonical Wnt signaling pathway, which leads to the
regulation of the transcription
of many
genes,» said principal investigator Denise Al Alam, PhD,
of the Department
of Surgery and the Developmental Biology and Regenerative Medicine Program
at The Saban Research Institute.
«We set out to find out about human
genes that are implicated in the
regulation of the gut microbiome, and we found some that are,» says senior author Ruth Ley, an Associate Professor in the Department
of Microbiology
at Cornell University and the study's senior author.
Currently, there is no cure to stop or reverse any form
of muscle - wasting disorders — only medication and therapy that can slow the process,» said Vittorio Sartorelli, M.D., chief
of the Laboratory
of Muscle Stem Cells and
Gene Regulation and deputy scientific director
at the National Institute
of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
«The disruption
of the circadian clock machinery seems to affect not only the rhythm
of appetite
regulation, but also the expression
of the
genes and proteins
at their absolute level,» says Turek, whose team reports its findings online today in Science.
Researchers from the Institute
of Neurosciences
at the Universitat Autònoma de Barcelona (INc - UAB) and the Vall d'Hebron Research Institute (VHIR) are the first to demonstrate that
regulation of the brain's Klotho
gene using
gene therapy protects against age - related learning and memory problems in mice.
He's also eager to return full time to his HHMI - supported lab
at the University
of California, Berkeley, which has shifted its work on
gene regulation from wet biochemistry to imaging single molecules in living cells.
To determine whether shifts in the balance
of anterior and posterior field occurred during fin - to - limb evolution, Onimaru, postdoctoral researcher currently
at Sharpe's lab (CRG), and his colleagues carefully compared the expression, function and
regulation of genes involved in anterior - posterior patterning in pectoral fins
of catsharks, with those
of mice.
At present, the
regulation of gene drive research does not fit within the purview of any of the U.S. agencies involved in the Coordinated Framework for the Regulation of Biotechnology, which includes the Food and Drug Administration, U.S. Department of Agriculture, and the U.S. Environmental Protecti
regulation of gene drive research does not fit within the purview
of any
of the U.S. agencies involved in the Coordinated Framework for the
Regulation of Biotechnology, which includes the Food and Drug Administration, U.S. Department of Agriculture, and the U.S. Environmental Protecti
Regulation of Biotechnology, which includes the Food and Drug Administration, U.S. Department
of Agriculture, and the U.S. Environmental Protection Agency.
«This is the first piece
of evidence that humans may have a faster rate»
of change in the
regulation of gene expression, notes Caro - Beth Stewart, a molecular evolutionist
at the State University
of New York, Albany.
Dean Hamer, head
of gene structure and
regulation at the National Cancer Institute, is endeavoring to link religion to a specific
gene.
Targeted
gene therapies, however, had to wait for (1) the identification
of the
genes to target, (2) the cloning and / or sequencing
of the relevant
genes and in some cases, the specific disease - causing variant, (3) a full understanding
of the normal
gene function and
regulation, and (4) the development
of efficient ways to deliver
genes to the relevant tissues
at therapeutic levels.
Asst Prof Li, from the Neural Stem Cells Laboratory
at NNI, added, «This important study suggests a link between a key neurological disease
gene and
regulation of microRNAs in the brain.
Scientists
at the Centre for Genomic
Regulation (CRG) in Barcelona, Spain, have developed a new technique to crack the underlying DNA code for the «control dials» that determine levels
of gene activity in bacteria.
Scientists have discovered many points
of regulation in the process
of using a specific DNA template to make a protein, known as
gene expression, that allow the cell to control how much
of a certain protein is made
at a certain time.
Indeed, to get the full picture
of gene regulation we need to look
at the three - dimensional organisation
of the chromatin that also coordinates
gene activity.»
He received his doctoral degree in 1996
at the Ludwig Maximilians University in Munich for work on activity - dependent
regulation of neurotrophin
gene expression.
In 1984, he moved to the Institute for Molecular and Cellular Biology,
at Osaka University (Osaka, Japan), where his research group continued to study the
regulation of interferon
genes and discovered the interferon - regulatory - factor family
of transcription factors.
With only a single
gene and a toolbox
of forward and reverse genetic approaches
at hand, C. elegans offers an opportunity to explore the exact role
of perlipin - related factors in fat
regulation throughout development
of many different somatic and germline cells.
Benedikt received his doctoral degree in 1996
at the Ludwig Maximilians University, Munich for work on activity - dependent
regulation of neurotrophin
gene expression.
The researchers were also able to see that over-consumption
of saturated fats seems to be able to «turn on» certain
genes in fatty tissue that increase the storage
of fat in the abdomen and
at the same time hamper insulin
regulation.
What is known from global studies is that exposure to biologically active compounds, even
at ng / L concentrations, can impact endocrine systems in nature and manifest as negative impacts like altered
gene regulation, the presence
of mixed reproductive tissues (intersex) and skewed sex ratios.
Marek is performing postdoctoral research in the lab
of Nick Ingolia
at UC Berkeley studying the
regulation of gene expression.
Finally, Yingjie Guan, assistant professor (research)
of orthopaedics
at Brown and Lifespan,
at the COBRE for Skeletal Health and Repair, talked about her detailed work on how mechanical
regulation of gene expression, for instance by the micro RNA miR - 365, affects cartilage and bone health.
He joined the Dimitris Thanos lab «
at the perfect time,» when a growing appreciation
of the importance
of chromatin in
gene regulation presented many opportunities for the ambitious and eager young scientist.
Throughout his postdoctoral years,
at Memorial Sloane - Kettering Cancer Center, and into his tenure
at the University
of Michigan, Dr. Al - Hashimi remained steadfast in his determination to solve the problem
of how to visualize atomic motion, «to obtain a deeper understanding
of gene regulation and to build new technologies for drug discovery and biotechnology.»
This metaphor is also a way
of looking
at gene regulation.
Fortunately, Paul Flicek and his colleagues
at EMBL - EBI are rising to the challenge by helping to curate, catalogue and give access to the masses
of genetic data being generated globally — not just
gene sequences, but outcomes
of studies into everything from
gene regulation to protein function.
We study learning and memory
at the genetic level to understand the structure,
regulation, evolution and biological function
of genes that are required for normal learning and memory.
Our colleagues
at Gladstone are using this knowledge to search for small molecules that can affect
gene regulation and reverse some
of the problems caused by the loss
of these transcription factors.»
«In addition to lending support to the idea that changes in
gene regulation are a key part
of our evolutionary history, these new results help to define exactly which regulatory factors may be important,
at least in certain tissues.
We have a longstanding interest in understanding
gene expression
regulation, and in our wetlab
at the Sanger Institute use mouse T helper cells as a model
of cell differentiation.
Researchers, funded by Cancer Research UK, from the Section
of Gene Function and Regulation and the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research (ICR), have pinpointed early genetic changes that lead to cancer in mice lacking the BRCA2 gene in their prostate gl
Gene Function and
Regulation and the Breakthrough Breast Cancer Research Centre
at The Institute
of Cancer Research (ICR), have pinpointed early genetic changes that lead to cancer in mice lacking the BRCA2
gene in their prostate gl
gene in their prostate gland.
«For 30 years scientists have suspected that
gene regulation has played a central role in human evolution,» said Kevin White, PhD, associate professor
of genetics and ecology and evolution
at Yale and senior author
of the study.
Lead author, Dr Amanda Swain, from the Section
of Gene Function and
Regulation at the ICR, said: «The discovery that BRCA2 alterations play the same role in the development
of hereditary prostate cancer as they do in breast cancer is an important step.
SAN FRANCISCO, CA — A scientist
at the Gladstone Institutes has discovered how
gene regulation can make hearts beat out
of sync, offering new hope for the millions who suffer from a potentially fatal heart condition.In a paper being published this week in the online Early Edition
of the Proceedings
PROJECT INFORMATION: RNA fate determination is
at the center
of gene expression
regulation, influencing the stability, localization, and translation efficiency
of mRNAs.