Sentences with phrase «at risk of adverse effects»

If you suffer from trimethylaminuria, renal disease, liver disease, depression or Parkinson's disease, you might be at risk of adverse effects with choline intakes.

Studies show more than 400 mg per day can put a person at risk of adverse effects.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

These risks and uncertainties include competition and other economic conditions including fragmentation of the media landscape and competition from other media alternatives; changes in advertising demand, circulation levels and audience shares; the Company's ability to develop and grow its online businesses; the Company's reliance on revenue from printing and distributing third - party publications; changes in newsprint prices; macroeconomic trends and conditions; the Company's ability to adapt to technological changes; the Company's ability to realize benefits or synergies from acquisitions or divestitures or to operate its businesses effectively following acquisitions or divestitures; the Company's success in implementing expense mitigation efforts; the Company's reliance on third - party vendors for various services; adverse results from litigation, governmental investigations or tax - related proceedings or audits; the Company's ability to attract and retain employees; the Company's ability to satisfy pension and other postretirement employee benefit obligations; changes in accounting standards; the effect of labor strikes, lockouts and labor negotiations; regulatory and judicial rulings; the Company's indebtedness and ability to comply with debt covenants applicable to its debt facilities; the Company's ability to satisfy future capital and liquidity requirements; the Company's ability to access the credit and capital markets at the times and in the amounts needed and on acceptable terms; and other events beyond the Company's control that may result in unexpected adverse operating results.

For example, the expected timing and likelihood of completion of the proposed merger, including the timing, receipt and terms and conditions of any required governmental and regulatory approvals of the proposed merger that could reduce anticipated benefits or cause the parties to abandon the transaction, the ability to successfully integrate the businesses, the occurrence of any event, change or other circumstances that could give rise to the termination of the merger agreement, the possibility that Kraft shareholders may not approve the merger agreement, the risk that the parties may not be able to satisfy the conditions to the proposed transaction in a timely manner or at all, risks related to disruption of management time from ongoing business operations due to the proposed transaction, the risk that any announcements relating to the proposed transaction could have adverse effects on the market price of Kraft's common stock, and the risk that the proposed transaction and its announcement could have an adverse effect on the ability of Kraft and Heinz to retain customers and retain and hire key personnel and maintain relationships with their suppliers and customers and on their operating results and businesses generally, problems may arise in successfully integrating the businesses of the companies, which may result in the combined company not operating as effectively and efficiently as expected, the combined company may be unable to achieve cost - cutting synergies or it may take longer than expected to achieve those synergies, and other factors.

There are other aspects of the NGP Report that merit further discussion, including its approach to adaptive management (we now have three different JRP reports in as many years that take different views on the extent to which AM can be relied upon in making a determination as to the likelihood of significant adverse environmental effects under CEAA), the precautionary principle, species at risk and Aboriginal consultation.

IF THE COMPANY BELIEVES, IN ITS SOLE DISCRETION, THAT ANY INDIVIDUALS OR ENTITIES OWNING CTK CREATES MATERIAL REGULATORY OR OTHER LEGAL RISKS OR ADVERSE EFFECTS FOR THE COMPANY AND / OR CTK, THE COMPANY RESERVES THE RIGHT TO: (A) BUY ALL CTK FROM SUCH CTK OWNERS AT THE THEN - EXISTING MARKET PRICE AND / OR (B) SELL ALL CRYPTOCURRENCY ASSETS OF THE COMPANY.

Based on this review, they concluded that the general population of healthy adults is not at risk for potential adverse effects from caffeine if they limit their consumption to 400 mg per day.

In addition to being more highly exposed to As, children appear to be far more sensitive to the potential carcinogenic effects of As49, 50 and have a heightened risk for adverse growth, adverse immune response, and adverse neurodevelopmental outcomes,25,51 - 53 even at relatively low levels of exposure.24, 54 Our results indicate that consumption of rice and rice products increases infants» exposure to As and that regulation could reduce As exposure during this critical phase of development.

Believing the old word of mouth that having dental treatment during pregnancy can have adverse effects on the health of your baby, is exactly what will put you and your baby at risk.

«A ban of polystyrene foam is going to have an adverse effect on the economy immediately, to include putting hundreds of upstate manufacturing jobs at risk.

For decades there has been some belief that pregnancy has an adverse effect on the course of melanoma, increasing the risk of its development, ability to spread throughout the body, and recurrence, said study coauthor Mark Faries, MD, FACS, who was director of therapeutic immunology at the John Wayne Cancer Institute, Santa Monica, Calif. at the time the study was conducted.

Researchers, led by Joshua Mayourian at the Icahn School of Medicine at Mount Sinai, used mathematical modeling to simulate electrical interactions between these stem cells and heart cells to develop insight into possible adverse effects, as well as to hypothesize new methods for reducing some potential risks of this therapy.

Furthermore, older patients are at risk from the adverse side - effects of adjuvant treatments such as hormone therapy or chemotherapy.

Ezio Bonifacio, Ph.D., of the DFG Center for Regenerative Therapies Dresden, Technische Universitat Dresden, Germany and colleagues randomly assigned autoantibody - negative, genetically at - risk children to receive oral insulin at varying doses (n = 15) or placebo (n = 10) once daily for 3 to 18 months to assess whether oral insulin can induce a potentially protective immune response without causing adverse effects.

«The advantage of being able to deliver methotrexate in this targeted way is to be able to gain the benefits from this key treatment of RA, while reducing the risk of adverse effects that are more frequent at high doses,» concluded Dr Macor.

«We observed that a multifaceted audit and feedback intervention aimed at health professionals results in a slight reduction in the rate of caesareans for low - risk pregnancies, without adverse effects on maternal and neonatal health,» revealed Nils Chaillet, principal investigator of the QUARISMA trial, researcher at the CHU de Québec - Université Laval Research Centre and professor at Université Laval's Faculty of Medicine.

New findings by a biomedical engineer and his team at the University of Houston (UH) raise hope for a new class of drugs to treat lupus that may not include the long list of adverse risks and side effects often associated with current treatments for this disease.

Risk of adverse effects of inhalers — Because postmenopausal women treated for asthma with inhalers (also known as inhaled corticosteroids) have significantly lower bone mineral density, they are at additional risk for osteoporoRisk of adverse effects of inhalers — Because postmenopausal women treated for asthma with inhalers (also known as inhaled corticosteroids) have significantly lower bone mineral density, they are at additional risk for osteopororisk for osteoporosis.

«Based on what we've seen so far, it's at least as effective as open surgery, is far superior in terms of risk and adverse effects and is minimally invasive,» Laxton said.

Professor Marco Metra, director of the Institute of Cardiology at the University and Civil Hospital of Brescia, Italy and co-principal investigator of RELAX - AHF, said: «We have reported that all of these adverse effects of a worsening heart failure event are related to increased overall mortality and that a worsening heart failure event itself is related to a two-fold increased risk of dying in 180 days.»

If so, and parents are informed of the results, they might decline to vaccinate children who are at increased risk of adverse side effects, risking infection for their children and undermining herd immunity for others.

«In contrast, the adverse effects of overweight on diabetes risk at puberty and older are only partially reversible.»

«no defined intake level at which potential adverse effects of protein was identified» and «there is no evidence that amino acids from usual or even high intakes of protein from foodstuffs present any risk.»

Some populations that tend to report shorter periods of sleep, like the elderly, could be at an even greater risk of these adverse health effects.

Although it is often suggested that children with epilepsy who are benefiting from ketogenic dietary therapy continue this for at least two years, duration of treatment could be shorter in patients with infantile spasms who become seizure - free; one study reported no adverse effect on seizure outcomes and less risk of growth disturbances when treatment was tapered down after 8 months (15).

30 % of long - term users will experience severe withdrawal or adverse effects which may include seizures, hallucinations, psychosis, akathisia, and sometimes suicide or death (people are especially at risk for severe withdrawal if they over-rapidly taper or cold - turkey their benzodiazepine / Z - drug).

Potassium from your diet should not cause adverse side effects — unless you're at risk of high potassium levels due to impaired kidney function — but potassium supplements can cause excessively high potassium levels.

Investments in illiquid securities pose risks related to uncertainty in valuations, volatile market prices, and limitations on resale that may have an adverse effect on the ability of the fund to dispose of the securities promptly or at reasonable prices.

Contrary to popular opinion, the vaccine has no more adverse effects than any other vaccine, so if the dog is at risk of contracting the disease, vaccination is wise.

Re-vaccinating these animals does not change their status, and only increases the risk of adverse effects without any benefit at all.

As discussed earlier, Hurricane Katrina demonstrated that communities of color, poor communities, and certain other vulnerable populations (like new immigrant communities) are at a higher risk to the adverse effects of extreme weather events.263, 264,239 These vulnerable populations could benefit from urban planning policies that ensure that new buildings, including homes, are constructed to resist extreme weather events.303

«(5) That some of the adverse and potentially catastrophic effects of global warming are at risk of occurring and not a certainty does not negate the harm persons suffer from actions that increase the likelihood, extent, and severity of such future impacts.

«Today's report recognizes that the livelihoods of people living in coastal communities, the sustainability of rich natural resources that support our economy and the security of residential, commercial and industrial assets are at great risk if we don't devise and implement plans to protect against, and recover from, the adverse effects associated with climate change.»

Raincoast Conservation Foundation and Living Oceans Society argued that the NEB and Cabinet failed to comply with the statutory requirements of the Species at Risk Act (SARA) with respect to the significant adverse effects of the Project on southern resident killer whales and their critical habitat.

Drivers who amass too many traffic ticket penalty points on their driving record within two years, however, are generally at risk of incurring adverse effects on their licensure.

Children who experience poverty, particularly during early life or for an extended period, are at risk of a host of adverse health and developmental outcomes through their life course.1 Poverty has a profound effect on specific circumstances, such as birth weight, infant mortality, language development, chronic illness, environmental exposure, nutrition, and injury.

Cannabis use can be a significant contributor to poor mental health, particularly when it begins at a young age.4, 5 The adverse mental health effects of cannabis use in the general population are increasingly recognised, including anxiety, depression, 6 — 8 psychotic disorders, 4, 9 — 12 dependence6, 7, 13 withdrawal14, 15 and cognitive impairment.16, 17 Starting to use cannabis before age 15 is associated with an increased likelihood of developing later psychotic disorders, increased risk of dependence, other drug use, and poor educational and psychosocial outcomes.5

Third, even after taking into account the effects of (1) established developmental risk factors and (2) concurrent circumstances and behaviors such as low SES, smoking, physical inactivity, and poor diet at 32 years of age, each adverse childhood experience still predicted a greater number of age - related - disease risks at that age (Table 3, panels 3 and 4).