Sentences with phrase «at some level of risk from»

Not exact matches

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

More from Balancing Priorities: What to do with your bond portfolio as Fed rates rise Credit scores are set to rise Don't make these money mistakes when you're just starting out «There is no sense in bearing the risk of an adjustable rate when you can lock in a fixed rate at essentially the same level,» he said.

Possible reasons for the increased lending activity include lower levels of regulation at smaller banks than at their larger counterparts, recent movement of lending staffers from large banks to small banks and an increased willingness of smaller banks to take on credit and interest risk, the report says.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

A separate experiment involving the willingness to sign up for a flu clinic found that people with lower levels of emotional intelligence can also block unrelated emotions from influencing their decisions about risk, simply by making them aware that their anxiety was not related to the decisions at hand.

These risks and uncertainties include competition and other economic conditions including fragmentation of the media landscape and competition from other media alternatives; changes in advertising demand, circulation levels and audience shares; the Company's ability to develop and grow its online businesses; the Company's reliance on revenue from printing and distributing third - party publications; changes in newsprint prices; macroeconomic trends and conditions; the Company's ability to adapt to technological changes; the Company's ability to realize benefits or synergies from acquisitions or divestitures or to operate its businesses effectively following acquisitions or divestitures; the Company's success in implementing expense mitigation efforts; the Company's reliance on third - party vendors for various services; adverse results from litigation, governmental investigations or tax - related proceedings or audits; the Company's ability to attract and retain employees; the Company's ability to satisfy pension and other postretirement employee benefit obligations; changes in accounting standards; the effect of labor strikes, lockouts and labor negotiations; regulatory and judicial rulings; the Company's indebtedness and ability to comply with debt covenants applicable to its debt facilities; the Company's ability to satisfy future capital and liquidity requirements; the Company's ability to access the credit and capital markets at the times and in the amounts needed and on acceptable terms; and other events beyond the Company's control that may result in unexpected adverse operating results.

The vast number of start - ups receiving capital today from inexperienced investors combined with excessive levels of funding at over-optimized valuations sets the stage for significant investor disappointment which puts us all at risk.

In short, because they pool longevity risk, can offer a well - diversified portfolio with longer - term investments, and are professionally managed, public pension funds deliver the same level of benefits as DC plans at only 46 percent of the cost.15 Any funds invested with the state pension fund would be kept in a separate investment pool from public sector funds.

Factors that could cause or contribute to actual results differing from our forward - looking statements include risks relating to: failure of DBRS to rate the Notes at the anticipated ratings levels, which is a closing condition, or at all; changes in the financial markets, including changes in credit markets, interest rates, securitization markets generally and our proposed securitization in particular; the willingness of investors to buy the Notes; adverse developments regarding OnDeck, its business or the online or broader marketplace lending industry generally, any of which could impact what credit ratings, if any, are issued with respect to the Notes; the extended settlement cycle for the scheduled closing on April 17, 2018, which may exacerbate the foregoing risks; and other risks, including those described in our Annual Report on Form 10 - K for the year ended December 31, 2017 and in other documents that we file with the Securities and Exchange Commission from time to time which are or will be available on the Commission's website at www.sec.gov.

Today, chambers of commerce from the Lower Mainland and Fraser Valley released a new research study which concludes that $ 50 billion in economic development along the Lower Fraser River is at risk unless all levels of government act now to address the serious issues facing the river.

Based on these and other serious risks to the economic benefits of the Fraser River, every chamber of commerce in the Lower Mainland — from the mouth of the river around Richmond, to the entrance to the Fraser canyon at Hope, are calling on senior levels of government to act now to commit funding to head off potential disaster.

The Board's assessment of this information at its May meeting was that inflation remained likely to increase gradually from its current level of around 2 1/2 per cent, but that upside risks to this forecast had receded, partly as a result of the March tightening.

Although in the land of technology, competition adapts quickly and a few years from now can be viewed as the distant future, we think the iPhone - maker represents a compelling risk - reward opportunity at current levels based on our analysis.

Investors need to keep these familiar risks in mind, Galligan says, but they also shouldn't lose sight of how «the tech landscape is far different from the last time the Nasdaq was at these levels.»

At current levels of rates and risk premiums, a mere 1 % increase in the discount rate (from 4.7 % to 5.7 %) would shave nearly 4 P / E points off the stock market's fair value on a trailing earnings basis.

With their winning streak at risk, it will now likely spark a reaction from Chelsea but it isn't the level of concentration that Conte demands from his players from the first minute to the last.

One way, I believe, to address the problem of under - reporting and increase the chances a concussion will be identified early on the sports sideline may be to rely less on athletes themselves to remove themselves from games or practices by reporting concussion symptoms (which the most recent study shows occurs at a shockingly low rate, [9] or on game officials and sideline observers to observe signs of concussion and call for a concussion assessment, but to employ technology to increase the chances that a concussion will be identified by employing impact sensors designed to monitor head impact exposure in terms of the force of hits (both linear and rotational), number, location, and cumulative impact, in real time at all levels of football, and in other helmeted and non-helmeted contact and collision sports, where practical, to help identify high - risk impacts and alert medical personnel on the sideline so they can consider performing a concussion assessment.

In the end, it all comes back to education: In the ideal world, a parent's decision about whether to allow a child to start playing or continue playing collision sports before high school under current rules of play (which are evolving in the direction of safety, fortunately, as seen, for instance, in USA Hockey's ban on body checking at the Pee Wee hockey level and below, and limits on full - contact practices instituted at every level of football, from Pop Warner, to high school, college, and the NFL), will be a conscious one; a decision in which the risks of participating in a particular sport - provided it is based on the most up - to - date information about those risks and a consideration of other risk factors that might come into play for their child, such as pre-existing learning disabilities (e.g. ADHD), chronic health conditions (e.g., a history of history of multiple concussions or seizures, history of migraines), or a reckless and overly aggressive style of play - are balanced against the benefits to the child of participating.

Noting that in most states football teams typically switch from limited contact levels during the preseason to two practices a day, at least one of which includes contact, they expressed concern that, based on their findings, «the brain may not be able to adjust quickly to this change, leaving players at increased risk for injury» at the beginning of the football season.

Research has demonstrated that a large proportion of mothers served in home visiting suffer from mental health problems, with up to 50 percent experiencing clinically elevated levels of depression during the critical first years of their child's development.5 There is evidence that many depressed mothers fail to fully benefit from home visiting.6 Identifying depressed mothers or those at risk for depression who are participating in home visiting, and treating or preventing the condition and its deleterious consequences, can improve program outcomes and foster healthy child development.

The psychosocial outcome receiving the most attention from researchers is problem behaviour, with most studies finding perceived negative reactivity in infancy to predict problem behaviour in childhood33, 34 and adolescent.35 Specifically, infants prone to high levels of fear, frustration, and sadness, as well as difficulty recovering from such distress, were found to be at increased risk for internalizing and externalizing problem behaviours according to parental and / or teacher report.

Can you use someone's level of social support as a predictive measure of how at risk the mom is of suffering from postpartum depression

Additional evidence from studies which have looked at other aspects of social support such as the level of received support or sources of social support also provided evidence to support the hypothesis that the level of social support is an important factor in postpartum depression and that if social support is absent then it can be a potential risk factor for postpartum depression.

The evidence suggests that assessing the level of social support (as well as other metrics such as depressive symptoms during pregnancy) could be one way to help highlight those at risk from depressive symptoms postnatally.

«Until they recognize that their policy positions are not in line with voters of this country, and until they start running candidates that are respected by the voters of their district, they run the very real risk of continuing to fall from the already... historically low level they're at.»

If Marcie's # 225 earnings are derived from being on or near the minimum wage, then there is a double hit for her because she also can not salary sacrifice to save 12 per cent National Insurance, if such an arrangement would take her pay below the level of the applicable minimum wage rate (# 7.83 per hour in 2018/19 for those aged 25 and over).3 Anne Fairpo said: «One of the concerns about allowing the lowest earners to sacrifice salary has been the risk of their pay dropping below the point at which entitlement to contributory benefits is triggered (the Lower Earnings Limit - # 116 per week in 2018/19).

While tougher regulations have driven lead levels down globally since the 1990s, mercury levels in the North Pacific Ocean have increased 30 percent over the last 20 years, potentially putting humans at higher risk of exposure from seafood (See «Made in China: Our Toxic, Imported Air Pollution»).

Rare mutations that shut down a single gene are linked to lower cholesterol levels and a 50 percent reduction in the risk of heart attack, according to new research from Washington University School of Medicine in St. Louis, the Broad Institute at Massachusetts Institute of Technology and Harvard, and other institutions.

An analysis of 41,302 blood samples taken from the entire study at different time points found that a child who had an intermediate antibody level and became infected again had a 7.64 times higher risk of being in the small group that developed DHS / DSS, researchers report today in Science.

Attanasio, an assistant professor of health policy and management at UMass Amherst's School of Public Health and Health Sciences, explains that a growing body of research at the individual level has shown that compared to women cared for by physicians, women considered at low - risk for complications in childbirth who receive care from midwives have good outcomes that include lower use of interventions such as cesarean delivery.

Silver Award: Alex Kuffner The Providence Journal «Rising seas, rising stakes» Nov. 20, 2016 «Losing ground» March 19, 2017 «On the brink» July 9, 2017 Judges praised Alex Kuffner for his comprehensive look at the risks facing Rhode Island communities from either a once - in - a-century hurricane or a sea level rise of seven feet by the end of the century, as projected in a worst - case scenario by researchers at the National Oceanic and Atmospheric Administration (NOAA).

This means that at a population level, an increased risk of psychosis from cannabis use is low, and those vulnerable to developing serious mental health problems is relatively rare.

Modelling flood risk in Europe — global warming the biggest influence In the framework of the HELIX FP7 Project, scientists analysed the differences in projected changes in flood risk at country scale under global warming scenarios of 1.5, 2 and 3 degrees from pre-industrial levels, and discussed reasons for the observed outcomes.

Patients with chronic obstructive pulmonary disease (COPD) who also have allergic disease have higher levels of respiratory symptoms and are at higher risk for COPD exacerbations, according to a new study from researchers at Johns Hopkins University in Baltimore.

In a linked editorial, Rebecca Burch from Harvard Medical School and Melissa Rayhill from The State University of New York at Buffalo caution that «the magnitude of the risk should not be over-emphasized,» as «it is small at the level of the individual patient, but still important at a population level because migraine is so prevalent.»

C - reactive protein, or CRP, levels were measured from 1,287 healthy, 42 - 60 year - old men at the onset of the Kuopio Ischaemic Heart Disease Risk Factor Study in 1984 - 1989 at the University of Eastern Finland.

«People at risk of bone diseases, have seasonal depression, or are obese should have their physicians measure vitamin D levels to ensure they're adequate, but for many, the best way to ensure adequate blood levels of the vitamin is from sun exposure, healthy diet, being active and maintaining a normal body weight.»

While controlling blood pressure, blood sugar and LDL - cholesterol levels reduces the risk of cardiovascular disease in people with diabetes, only 7 percent of diabetic participants in three major heart studies had recommended levels of these three factors, according to research from the Heart Disease Prevention Program at the University of California, Irvine School of Medicine.

In addition to new diabetics, people who are at risk of developing type - 1 diabetes, such patients» close relatives, also may benefit from the test because it will allow doctors to quickly and cheaply track their auto - antibody levels before they show symptoms.

Life insurance companies routinely request HIV tests from anyone who wants an unusually high level of cover, for example above # 250 000, and from people they consider to be at high risk.

We found that upon closer observation that several of the species being preserved are under great commercial pressure for timber putting them at greater risk of extinction — observations that might be lost in high - level imaging such as those derived from satellites.»

noted a skeptical Manny Diaz, former mayor of Miami, a coastal city even more at risk from the stronger hurricanes and sea level rise as a result of climate change.

Women who had the highest levels of risk at the start of the study benefitted the most from modest weight loss.

In the April 13, 2007, issue of Science, the research team — led by James C. Lo, an MD, PhD student, in the laboratory of Yang - Xin Fu, MD, PhD, professor of pathology at the University of Chicago — suggest that an engineered protein could keep mice, and possibly humans, from developing high cholesterol and triglyceride levels, a key risk factor for coronary heart disease.

«This nested design uses a bioecological framework to measure risk and protective factors at multiple levels of analysis — «from neighborhoods to neurons and beyond,»» Jacobson said.

Based on regional studies, the Intergovernmental Panel on Climate Change (IPCC) estimated that 20 — 30 % of the world's species are likely to be at increasingly high risk of extinction from climate change impacts within this century if global mean temperatures exceed 2 — 3 °C above pre-industrial levels [6], while Thomas et al. [5] predicted that 15 — 37 % of species could be «committed to extinction» due to climate change by 2050.

Reykjavik, ICELAND, 9 October 2011 — Scientists at deCODE Genetics and academic collaborators from Iceland, Norway, Denmark, the Netherlands and the USA today report the discovery of low frequency variants in the human genome that associate with risk of gout, a common inflammatory arthritis, and serum uric acid levels.

Children who are maltreated may be at an increased risk of obesity and inflammatory disorders because of low levels of leptin — a hormone involved in regulating appetite, according to new research from King's College London.

A conclusion from the study was that doing unilateral exercises helps a person in fast recovery after the workout and the risk of injuries is at an acceptable low level.