Sentences with phrase «at some of the factors comprising»

So let's look at some of the factors comprising my optimistic viewpoint.

Not exact matches

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

A variety of factors were considered when establishing the teams; each team would comprise teachers at different levels of experience and from different content areas.

It's debatable as to why exactly West Virginia was the state to precipitate this fledgling national teachers» movement, but experts tend to agree it comprised, in the words of Paul Reville, a professor of education policy and administration at Harvard's Graduate School of Education, «a perfect storm of factors.»

Valuation Chart at Left: Compares the Hartford Funds Value Factor Score, a composite measure of relative valuation based on five measures of value, of the stocks that comprise RODM with the stocks within the MSCI World ex USA Index.

The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.

Litigants and litigators are likely to become more confused in the future than they ever were by the standard of review analysis: at least the categorical approach's predecessor comprised four fixed factors.

The proposed project will involve two main sequential activities: a) to develop an EBP system comprised of a set of feasible, theoretically coherent and technically consistent practice elements that are aimed at reducing future incidents of physical abuse, and a simple set of decision rules that match elements with key client or context factors and b) to conduct a feasibility and pilot trial of the modular model.