Sentences with phrase «at synaptic»

Prior 2002: Worked as a Laboratory Assistant at Synaptic Pharmaceutical, Paramus • NJ; Research Assistant at Pepsi - Cola Company / Research and Development Department, Valhalla • NY; Assistant QC Coordinator / Research Assistant at Vitex, Inc., New York • NY

But how this happens at the synaptic level in people is still very difficult to figure out.

Hypothalamic explants were then used to assess the intracellular localization of PRCP and its release at the synaptic levels.

This includes proposals that address mechanisms of memory or cognition at the synaptic, cellular, molecular, genetic or behavioral level in animals, including humans.

«Before the work of Scheller, Südhof and Rothman the target for these toxins was known to be at the neuromuscular junction and at the synaptic membrane, but the molecular target was not known,» says Neuroscience Prize Committee member Jean - Pierre Changeux at the Pasteur Institute, Paris.

Projection neurons form connections with memory neurons at synaptic junctions that resemble small bulbs strung along the wire - like axons.

«While our findings are consistent with other reported changes in neuronal firing rates with attention, they go far beyond such descriptions, revealing never - before tested mechanisms at the synaptic level,» said study co-author Farran Briggs, PhD, assistant professor of Physiology and Neurobiology at the Geisel School of Medicine.

Over-activation of the D2 class of dopamine receptors led to suppression of the function of NMDA receptors, which are activated by the neurotransmitter glutamate, at the synaptic connection between hippocampus and prefrontal cortex.

The correct positioning of the process of a postembryonic sensory neuron, the touch cell AVM of the nematode Caenorhabditis elegans, at its synaptic targets requires the presence of a pair of embryonic interneurons, the BDU cells.

Maybe it will prove possible to see if the older brain becomes stiffer at the synaptic level, in the same way that the ageing body does at the level of the skin, muscles and joints.

However, because the treatments affected the cultures globally and did not precisely target synapses, the researchers next applied substances that increase the firing of glutamate neurons by acting solely at synaptic sites.

According to director William Mobley, the goal is to translate the science «all the way from looking at synaptic function to deciding how children can learn how to read more effectively.»

Tactus confirmed to TechCrunch that it has partnered with touch panel experts at Synaptics to create a reference device — a 7 - inch Android - powered tablet — that it will begin shopping around to OEMs and carriers at the end of June.

«Synaptics» FS9100 family of fingerprint sensors represent a new breed of optical fingerprint sensor technology that is designed to meet the needs of mobile devices, including the ability to image through a thick 2.5 D glass,» said Anthony Gioeli, vice president of marketing in the biometrics product division at Synaptics, in a statement.

Not exact matches

Of course, a question at least as big is: Does the president - elect devote even a fraction of a synaptic pulse to Canada?

The iPhone supplier Synaptics (NASDAQ: SYNA) saw its rating raised to buy from hold at Mizuho.

In October researchers at Columbia University reported that young mice predisposed to acquiring Alzheimer's accumulate protein clusters in synaptic mitochondria and that these clusters directly impair synapse function.

But no one knew how, exactly, mitochondria were linked to synaptic problems, if at all.

Cognitive computing researchers at IBM are developing a new generation of «neuro - synaptic» computer chips inspired by the organization and function of the brain.

Pasko Rakic at Yale University and colleagues at the University of Zagreb, Croatia, and the VU University Medical Center in Amsterdam, the Netherlands, have now found that the brains of adults in their 20s are still subject to synaptic pruning.

At first Modha and his team hit a wall before they reached 40 percent of the number of neurons present in the mouse cerebral cortex: roughly 8 million neurons, with 6,300 synaptic connections apiece.

Researchers in Guoping Feng's lab at MIT hypothesized that a mutation in Shank3 differentially affects synaptic development in two neural pathways that contribute to motor control.

Previous research by Burger and Stefan Oline — a former Ph.D. candidate at Lehigh, now a postdoctoral fellow at New York University Medical School — demonstrated for the first time that synaptic inputs — the messages being sent between cells — are distinct across frequencies and that these different impulse patterns are «mapped» onto the cells of the cochlear nucleus.

«We looked at the effects of propofol — one of the most common general anaesthetic drugs used during surgery — on synaptic release,» the UQ Queensland Brain Institute scientist said.

Dr Victor Anggono, whose laboratory at QBI focusses on synaptic mechanisms, was a partner in the study.

White is interested in human behavior, but said humans are difficult to study at the cellular and synaptic level.

Moser's approach — risky at the time, he says — merged psychology with physiology, investigating synaptic plasticity by recording neural signals from intact mammalian brains.

This only happened at the site of active synaptic transmission.

At the cellular level, learning and memory require continuous readjustment of the strength of synaptic junctions — the functional connections between nerve cells.

«This work shows that dendritic spines, which are sub-micrometer compartments within individual neurons, are the prime candidates for the initial tag of transient, millisecond synaptic activity that eventually orchestrates memory traces in the brain lasting tens of years,» said Shahid Khan, senior scientist at the Molecular Biology Consortium at Lawrence Berkeley National Laboratory and a co-author on the PNAS paper.

The researchers developed a synaptic device that can reconfigure itself based on voltages applied at the input terminal of the device.

It's the first time neuroscientists have been able to look at the behavior of synaptic circuits at such a fine - grained level of resolution while measuring the effects of attention, said Professor Ron Mangun, dean of social sciences at UC Davis and a researcher at the UC Davis Center for Mind and Brain.

«We don't have evidence that [such proteins are] driving the whole process but we think it's an early part, and if you knock it out or manipulate it, you could have the promise of an early impact and protecting at least the synaptic part of the story.»

In subsequent research at the Stowers Institute, Si and his team identified Orb2 as the fruit fly version of the CPEB synaptic protein.

This is the crucial chicken - or - egg puzzle of synaptic plasticity that a team led by Anthony Holtmaat, professor in the Department of Basic Neurosciences in the Faculty of Medicine at UNIGE, is aiming to solve.

Conducted among more than 170 subjects at various stages of Alzheimer's disease, the study by the team led by Salah El Mestikawy (Douglas Mental Health University Institute, Canada) and Stéphanie Daumas (Université Pierre et Marie Curie, France) has shown instead that the disease is accompanied by a minor decline in neuronal and synaptic markers.

There is no specific time at which neurons are active, instead dynamic interactions or time - dependent changes between neurons within the network provide information about lapsed time (e.g., short - term synaptic plasticity, inhibitory feedback, etc.).

Beginning in 1988 Scheller, then at Stanford, succeeded in characterizing several key proteins necessary for synaptic vesicle fusion with the presynaptic membrane, the prerequisite step for neurotransmitter release.

This conclusion is provocative because the dogma has been that a memory is instead stored by synaptic strength,» says Susumu Tonegawa, the Picower Professor of Biology and Neuroscience, the director of the RIKEN - MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, and the study's senior author.

Along the long axis of PFs, the CB1 was localized at a much higher density on the perisynaptic membrane than on the extrasynaptic and synaptic regions.

During his PhD work at the Lyon Neuroscience Center (France), he worked on the regulation of postnatal synaptogenesis and synaptic remodeling associated with learning and memory.

A Postdoctoral Fellow position is available in the lab of June Liu, Ph.D. in the School of Medicine, Department of Cell Biology and Anatomy at LSU Health Sciences Center in New Orleans to study synaptic and neural circuitplasticity in brain slices and its role in learning and memory.

At hippocampal excitatory synapses on pyramidal neurons the cannabinoid - induced synaptic suppression was reversed by a CB1 - specific antagonist, N -(piperidin -1-yl)-5 -(4 - iodophenyl)-1 -(2,4 - dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251), and was absent in CB1 knock - out mice.

To determine whether the protein in question, at the time known as BNPI, mediated the transport of glutamate into synaptic vesicles, the researchers inserted the BNPI DNA into rat cells that normally lacked BNPI protein.

The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD - 2 / liprin and UNC - 10 / RIM - dependent interactions.

Advances in optical imaging and optogenetics combined with electrophysiological recordings enable Albeanu and colleagues to monitor and / or alter patterns of activity at unprecedented synaptic and millisecond resolution, in real time, as animals are engaged in various behaviors.

This project will increase our fundamental knowledge of the synapse and will shed light on the physiopathology of several neuropsychiatric illnesses in which synaptic defects are at the core of the disease.

Pathological hallmarks of AD, including plaques and loss of synaptic markers, are readily apparent at nine months of age in huAPP / PS1 mice along with clear deficits in spatial memory when compared to wild type controls [7, 10, 11, 31].

Bergersen LH, Morland C, Ormel L, Rinholm JE, Larsson M, Wold JF, Røe AT, Stranna A, Santello M, Bouvier D, Ottersen OP, Volterra A, Gundersen V (2012) Immunogold detection of L - glutamate and D - serine in small synaptic - like microvesicles in adult hippocampal astrocytes Cereb Cortex, 22 (7), 1690 - 7 PubMed 21914633

With this technique we can study synaptic plasticity at its most fundamental level.