Sentences with phrase «at telomere»

In looking at telomere length, an abnormal increase in telomere loss can tell us there may possibly be an immunoproliferative disorder (the inability to handle oxidative stressors), metabolic abnormalcy, or progressive chronic disease that is present.

So, even though doing sports may not delay molecular aging at telomere level, it does help you with the heart attack and cancer hurdles.

By clinically looking at your telomere lengths you can gain insight into how rapidly or slowly your body is aging.

Lundblad's group also developed a high - resolution assay that detects very small changes at each telomere as a cell divides.

But well - designed studies looking at telomere length and signs of health like resting heart rate have begun to provide new details concerning telomeres» effects on biological processes, which may help us establish causality in the future.

It is unclear how the entire body is affected because Spector looked only at telomeres, nucleotides on the ends of chromosomes that slowly erode as cells copy themselves during normal aging.

The team observed a relative scarcity of nucleosomes at telomeres from ASF1 - depleted cells, as one might expect once a histone chaperone is lost.

The study demonstrates that RingoA is active at telomeres — structures that protect the ends of chromosomes and where Cdk2 is also found.

This helps support our earlier observation about DNA loss being concentrated at telomeres in the hg19 genomic background shown in Fig 4.

We are currently studying the mechanisms by which telomeres are recruited to these structures and how recombination reactions, which are normally suppressed at telomeres, are allowed in the ALT context.

The team found that deleting the PIN domain from Chp1 prevented heterochromatin formation at the telomeres but didn't affect formation at the centromere.

«RITS might be exerting its effect at centromeres through Ago1 and the RNAi machinery, but might enforcing its function at the telomeres through Chp1 and its PIN domain.»

The advance of fundamental molecular aging is measured by looking at the telomeres in our DNA.

Not exact matches

Researchers from several institutions, including, UCLA, Boston University, Stanford University and the Institute for Aging Research at Hebrew SeniorLife, analyzed blood samples from nearly 10,000 people to find that genetic markers in the gene responsible for keeping telomeres (tips of chromosomes) youthfully longer, did not translate into a younger biologic age as measured by changes in proteins coating the DNA.

«With longevity and the ability to bear children at an older age associated with longer telomere length, this study suggests that a higher maternal age of successful child bearing may be a marker of healthy aging,» says Dr. JoAnn Pinkerton, NAMS executive director.

Telomere proteins from ciliated protozoa bind to the single - stranded G - rich DNA extensions at the ends of macronuclear chromosomes.

Not long afterward, biogerontologist Thomas von Zglinicki and his colleagues at Humboldt University in Berlin published a paper suggesting that telomere shortening could be hastened by oxidative damage.

In this study, the proportion of women in the longest telomere tertile was higher for women in the fourth quartile of maternal age at the birth of their last child than in the first quartile (35.7 % vs 20.2 %).

Voice: The 2009 Nobel Prize in Physiology or Medicine goes to Harvard's Jack Szostak, Johns Hopkins's Carol Greider and Elizabeth Blackburn at U.C. San Francisco for their work on how chromosomes are protected by telomeres and the enzyme telomerase.

The study «Telomere length is longer in women with late maternal age,» used data from LLFS to show that certain factors associated with the rate of aging and longevity, such as telomere length, are also associated with later maternal age at the birth of the lasTelomere length is longer in women with late maternal age,» used data from LLFS to show that certain factors associated with the rate of aging and longevity, such as telomere length, are also associated with later maternal age at the birth of the lastelomere length, are also associated with later maternal age at the birth of the last child.

Austad recalls one conversation in which Muller made an insightful connection about telomeres, the DNA - and - protein caps at the ends of chromosomes that shorten with every cell division, eventually pushing cells into a nondividing state called senescence.

(Earlier work by David Lydell and Laura Maringele at the University of Manchester, U.K., hinted that an exonuclease could chew up telomeres.)

12 Telomeres, sequences of DNA at the tips of chromosomes, get shorter every time a cell divides; when they get too short, the cell dies.

The personal telomere test, like the personal genome test, is coming at a time when we've still got many more questions about what it will reveal than solid answers.

How much a certain change — say, running or cutting back on fat — is going to affect your telomeres, if at all, is a level of specificity that the research can't yet provide.

«Such a relationship between leukocyte telomere length and physical activity level remained significant after adjustment for body mass index, smoking, socioeconomic status and physical activity at work,» the authors report.

In August, 1997, Nobelist Thomas Cech of the University of Colorado at Boulder and colleagues at Geron isolated the human gene for telomerase reverse transcriptase (hTRT)-- an enzyme that reknits loosening telomeres and extends a cell's life.

The telomere prevents this problem by employing a different mechanism to synthesize DNA at this point, thereby preserving the sequence at the terminal of the chromosome.

The team is now examining telomere length in additional populations to evaluate whether some groups based on age, gender, smoking history and other factors may be at additional increased risk.

The key to cancer cell immortality are the cell's telomeres, repetitive stretches of DNA at the ends of chromosomes that may protect the chromosomes when they divide.

Mariela Jaskelioff and her colleagues at the Dana Farber Cancer Institute in Boston, Massachusetts, engineered mice with short telomeres and inactive telomerase to see what would happen when they turned the enzyme back on.

By using this technique, we demonstrated that the telomere G - tail length of leukocytes is significantly correlated with endothelial function and severity of ARWMCs,» said Professor Hidetoshi Tahara, a principal investigator of this study at the Department of Cellular and Molecular Biology, Hiroshima University.

Viral integration into telomeres can disrupt chromosome function and spark a plethora of complications, including cancers, says Steven Jacobson, chief of viral immunology at the National Institute of Neurological Disorders and Stroke, who was not involved in the work.

To search for new enzymes that could repair telomeres, the researchers — Susan Smith, Titia de Lange, and their colleagues at Rockefeller University in New York City — used a biochemical screen to find substances that interact with TRF1, a human protein known to bind to telomeres.

Located at the ends of chromosomes, telomeres typically shorten with each cell division, until the end of the chromosome becomes so frayed that the cell dies.

Individuals carrying the variant had shorter telomeres, stretches of DNA at the ends of chromosomes that protect them from daily wear — and also aging

At Baylor, he studied telomere replication proteins in yeast.

It also means that the role of telomere biology at a very early step of cancer development is vastly underappreciated,» said senior author Dirk Hockemeyer, a UC Berkeley assistant professor of molecular and cell biology.

However, Steven Henikoff, a biochemist at Fred Hutchinson Cancer Research Center in Seattle, Washington, calls this scenario «highly improbable,» pointing out that new centromeres are evolving all the time, and not from telomeres.

Great tits raised in an urban environment have shorter telomeres — protective caps at the ends of chromosomes — than those raised in rural environments, researchers find.

Babies born to obese mothers have shorter telomeres - equivalent to up to 10 years» extra ageing - which may put them at risk of diabetes and heart disease

In vertebrates, telomeres act as protective caps located at the ends of chromosomes.

It potentially also suggests applications for the human ageing process even at old age when telomere length has already decreased,» said Dr Grishma Rane, Research Fellow at CSI Singapore and co-first author of the study.

«Nevertheless, we have evidence that the second step has to happen, and that the second step is initiated by or is occurring at a time where telomeres are critically short and when telomeres can be dysfunctional and drive genomic instability,» he said.

Telomeres at their ends act as caps to prevent biochemical wear and tear, while the cell choreographs the movement of chromosomes by grabbing hold of its centromere handle.

Telomeres are the protective tips found at the end of each DNA strand and are indicative of cellular aging.

The participants» telomere lengths were measured at two time points 13 years apart, through salivary specimens and buccal swabs.

Telomeres are tiny fragments of DNA at the end of each chromosome.

«Telomeres, the protein caps on the ends of human chromosomes, are markers of aging and overall health,» said Naruhisa Yamaki, M.D., a clinical fellow at the Kobe University Graduate School of Medicine.

Even chronic stress can wear away our telomeres, according to research done in the early 2000s that looked at mothers caring for children with chronic diseases.