Pathology involves looking
at tissue samples and cells in body fluids under the microscope and making a diagnosis based upon the findings.
Researchers looked
at tissue samples from the intestinal walls of «447 newly affected and 221 non-affected people» and found an overabundance of certain bacteria types was linked to inflammation levels.
Researchers looked
at tissue samples from ovarian cancer patients.
Among other tests, they looked
at tissue samples of breast cancer that had spread to the liver, lung and other organs.
Not exact matches
There are only a few instances of the polymer being assayed in the milk of women with implants; the concentrations are not elevated over control
samples.20 There is no evidence
at the present time that this polymer is directly toxic to human
tissues; however, concern also exists that toxicity may be mediated through an immunologic mechanism.
Crimson receives daily feeds of information on biosamples — mostly blood, but also urine,
tissue, cerebrospinal fluid, and bacterial collections — from patients in Harvard - affiliated clinical laboratories and the pathology laboratory, which includes some 5000 blood
samples collected daily
at Brigham and Women's and Massachusetts General hospitals.
The genetic analysis was made possible by
tissue samples available through the Total Cancer Care ® Protocol
at Moffitt.
Government inspectors
at slaughterhouses would likewise benefit from an immediate on - site detection method, helping them identify carcasses of infected cows faster than current laboratory testing, which takes up to 48 hours to process
tissue samples.
Taubenberger, who with his colleagues
at the Armed Forces Institute of Pathology first fished the 1918 H1N1 pandemic strain out of preserved
samples of victims»
tissue in 1996, says too much is still unknown about the basic biology and ecology of flu viruses.
Senior author Madhav Dhodapkar, M.D., the Arthur H. and Isabel Bunker Professor of Medicine and Immunobiology, and chief of Hematology, said the study, using
tissue and blood
samples from humans and mice, shows that chronic stimulation of the immune system by lipids made in the context of inflammation underlies the origins of
at least a third of all myeloma cases.
The interdisciplinary project team is made up of eco - and human toxicologists, physicists, chemists and biologists, and they have just managed to take their first major step forward in achieving their goal: they have developed a method for testing a variety of environmental
samples such as river water, animal
tissue, or human urine and blood that can detect nanomaterials
at a concentration level of nanogram per liter (ppb — parts per billion).
He contacted Susan Murch, a biochemist
at the Hospital for Sick Children in Toronto and an expert in finding biomolecules in human
tissues, to test the
samples in a double - blind study.
Investigators sent
tissue and blood
samples to Michael McIntosh
at the U.S. Department of Agriculture's Foreign Animal Disease Diagnostic Laboratory
at the Plum Island Animal Disease Center in Greenport, N.Y. McIntosh says he was surprised to find that the
tissue samples also contained the Reston strain, which had not been previously identified in swine.
The investigators looked
at 4,278 tumor
samples from a
tissue repository of patients with GI tract cancers.
As
tissue and DNA
samples are shared more widely than ever, scientists and federal agencies are looking more closely
at their responsibilities to the research subjects.
In lab experiments using
tissue samples cultured from cystic fibrosis patients, scientists
at the UNC School of Medicine and the UNC Marsico Lung Institute have shown that a new CF drug counteracts the intended beneficial molecular effect of another CF drug.
Dr Katarina Kos, Senior Lecturer
at the University of Exeter's Medical School, examined
samples of fat and
tissue from patients, including those with weight problems who have undergone bariatric surgery.
Researchers examined
tissue samples taken
at the time of surgery and assessed it for various markers, including MSI.
Brothwell has asked Konrad Spindler and his colleagues
at the University of Innsbruck, the current custodians of the mummy, for
samples of other
tissues that could provide more clues to Ötzi's profession.
Extended field excursions often begin
at such outposts, like the 3 - week hiking expedition from Ny - Ålesund two Norwegians and an American conducted in July to collect
tissue samples from reindeer.
Lead author Christina von Roemeling, a graduate student
at Mayo Clinic in Florida, used genomic profiling of nearly 100 kidney cancer patient
samples to identify genes that were either over-expressed or under - expressed as compared to patient matched normal kidney
tissue samples.
In this particular case, the researchers used DESI mass spectrometry imaging to look
at the distribution and amounts of fatty acid substances, called lipids, within breast
tissue and normal
tissue from 61
samples obtained from 14 breast cancer patients that underwent mastectomy.
Looking
at just one or two molecules in cell or
tissue samples is fairly straightforward.
«Our study addressed an important safety issue — whether cancer cells that might be present in testicular
tissue samples can survive the process to replicate the sperm - producing stem cells,» said lead author Hooman Sadri - Ardekani, M.D., Ph.D., an instructor in urology and regenerative medicine
at Wake Forest Baptist Medical Center.
As part of a DNA study of the world's cats, Stephen O'Brien and his team
at the National Cancer Institute (NCI) in Frederick, Maryland, collected blood and
tissue samples from 209 puma in zoos, museums, and the wild across North and Central America, and from 106 of the animals in South America.
Researchers
at the Cancer Research UK Cambridge Institute sprayed a dye on esophageal
tissue samples taken from people with Barrett's esophagus — a condition that increases the risk of developing esophageal cancer.
At intervals over the next 26 hours, the researchers took
samples from different
tissues within the sea cucumbers, and tested them for carbon - 14 and iron.
Several researchers say the center is benefiting from hard lessons learned from Tropical Storm Allison, which in 2001 breached aging dykes
at Texas Medical Center and flooded hospital basements, killing thousands of research rodents and thawing frozen
tissue samples.
NYGC computational biologists and members of the Simon Laboratory
at The Rockefeller University discussed the possibility of using a series of computer algorithms to search for sequence differences between the tumor
samples and
samples of healthy liver
tissue.
For the new study, described in the October 23rd issue of Nature Communications, scientists
at the Johns Hopkins Kimmel Cancer Center and Dana Farber Cancer Institute in Boston collected
tissue samples containing normal cells, ovarian cancers, metastases that had spread elsewhere, and small cancers found in the fallopian tubes, which included single cell layers of cancer called «p53 signatures» and serous tubal intraepithelial carcinoma, or STIC lesions.
The
tissue samples were subjected to molecular - genetic analyses
at the Institute of Anthropology
at Mainz University.
So in this study, he and other researchers
at Yale used a microscope to examine
tissue samples acquired from placenta saved by various research hospitals.
The
sample comes from the same T. rex femur that hit the headlines two years ago when Mary Schweitzer
at North Carolina State University, US, found it contained soft
tissue she interpreted as blood vessels.
To see whether the regional emissions reductions were having an effect on fish
at the top of the ocean food chain, researchers from Stony Brook University, the University of Massachusetts and Harvard University collected and analyzed
tissue samples from nearly 1,300 Atlantic bluefin tuna captured between 2004 and 2012.
In collaboration with colleagues
at Genentech, researchers analyzed 216 malignant pleural mesothelioma (MPM)
samples, comparing DNA and RNA from normal
tissue to cancerous
tissue.
Nevertheless, the researchers were able to carefully capture a total of 51 dwarf lemurs in live traps
at nine locations for this study and to take minute
tissue samples before releasing the animals back into their natural habitat.
«Our findings show that high - intensity circulating tumor DNA sequencing is possible and may provide invaluable information for clinical decision - making, potentially without any need for tumor
tissue samples,» said lead study author Pedram Razavi, MD, PhD, a medical oncologist and instructor in medicine
at Memorial Sloan Kettering Cancer Center (MSK) in New York, NY.
Eventually, by drawing on Georgiadis's
tissue collection, Lori Eggert's West African
samples, and the gleanings of other on - site collectors, Wasser's team
at the Center for Conservation Biology
at the University of Washington assembled a bank of 354
tissue samples and 491 fecal
samples, collected from 45 locations in 23 countries, that together account for over 85 percent of Africa's surviving elephants.
«It was a challenge to extract this genetic material in significant quantities and sufficient quality from the mummified
tissue samples, and to measure and quantify it with the newest, very precise methods,» reports Stephanie Kreis, who isolated the microRNAs
at the University of Luxembourg.
Researchers
at Sanford - Burnham Medical Research Institute have identified a set of RNA molecules that are detectable in
tissue samples and urine of prostate cancer patients, but not in normal healthy individuals.
They analyzed not only
tissue samples from the Iceman, but also those from a mummy of a soldier fallen in World War I. «Our investigation provides evidence that we can analyze microRNA even after thousands of years,» explains Andreas Keller, Professor of Clinical Bioinformatics
at Saarland University, who coordinated the study.
Hung and his colleagues collected tiny
tissue samples from four well - preserved passenger pigeons held
at museums around the world and used cutting - edge genetic technology to sequence the animals» DNA, as well as the DNA of a modern relative, the domestic pigeon.
Livia Eberlin
at the University of Texas, whose team created the device, tested it on 253 human
tissue samples (Science Translational Medicine, doi.org/cctx).
Additional tests in
tissue samples from osteoarthritic patients who had joint replacements
at NYU Langone found similarly increased levels of adenosine A2A receptors on chondrocytes.
Interestingly, many of the genes identified in this study have been shown to have lower gene activity
at the molecular level in autistic post mortem brain
tissue samples.
A group led by Eleanor Rogan, a cancer researcher
at the University of Nebraska Medical Center in Lincoln, took
samples of healthy breast
tissue from women with and without cancer and measured the amounts of estrogen derivatives.
This research was made possible by patients who were treated
at Moffitt and generously donated blood and
tissue samples to the Total Cancer Care ® Program and was supported in part by grants from the American Cancer Society (93-032-16) and the National Cancer Institute.
At the moment, prenatal diagnosis for a small number of genetic conditions is usually done from fetal cells that doctors capture from fluid in the womb (amniocentesis) or a snippet of placental
tissue (chorionic villus
sampling).
In this collaborative study, Wilkinson and Yanjun Lu, PhD,
at the Tongji University in China, and their research teams compared human lung IMT
samples and normal lung
tissue samples from the same patients.
An LPS - depleted collagenase cocktail (Liberase 3; Roche Applied Science, Indianapolis, Indiana, USA)
at a concentration of 0.03 mg / ml and 50 U / ml DNase I (Sigma - Aldrich) was added to the
tissue suspension and the
samples were incubated
at 37 °C on an orbital shaker (215 Hz) for 45 — 60 minutes.