«This combination of features means that the drugs can not only attack the main tumor site, but are more likely to find and attach themselves to tumor cells circulating in the bloodstream — essentially
attacking new tumors before they start,» says Quanyin Hu, lead author of the paper and a Ph.D. student in the joint biomedical engineering program.
Not exact matches
«When cancer comes back, it's genetically very similar to the original
tumor but often with additional mutations that may give cancer cells
new strategies to survive
attack by whatever drugs are thrown at them.
Now, thanks to the
new mouse model, it will be possible to study how renal
tumors are able to develop in an environment with a normal immune system, and how cancer cells manage to evade the immune system's
attacks.
A
new optogenetic technology developed by scientists at the University of Massachusetts Medical School and Texas A&M Health Science Center Institute of Biosciences & Technology, called optogenetic immunomodulation, is capable of turning on immune cells to
attack melanoma
tumors in mice.
Orchestrating a successful immune
attack against
tumors has proven difficult so far, but a
new study from MIT suggests that such therapies could be improved by simultaneously activating both arms of the immune system.
A
new class of drugs called immune checkpoint inhibitors block molecules on T cells that shut down immune response, freeing the immune system to
attack tumors.
Tumor necrosis factor inhibitor drugs (commonly called Anti-TNFs) modestly reduce the risk of acute coronary syndrome, such as heart
attacks and angina, in rheumatoid arthritis patients whose inflammation places them at higher risk of developing coronary heart disease, according to
new research findings presented this week at the American College of Rheumatology Annual Meeting in San Diego.
New research out of the University of Michigan supports combining two approaches to fight back against gliomas:
attacking the
tumor with gene therapy while enhancing the immune system's ability to fight it, too.
In the
new study, the researchers used a combination of four different therapies to activate both of the immune system's two branches, producing a coordinated
attack that led to the complete disappearance of large, aggressive
tumors in mice.
It also may have helped several others by boosting the power of a
new type of cancer drug that uses a different mechanism to unleash an immune
attack on the
tumor.
Once these targets are uncovered, we can then administer T cells that are genetically programmed to
attack tumor cells with the
new targets.»
Other research at U-M is developing
new options for treating brain cancer through immunotherapy — harnessing the immune system to
attack cancer cells once an injection of a particular gene therapy is delivered into the brain
tumor.
In their most intriguing work, they're collaborating on something
new: a «theranostic» nanoparticle that can both diagnose and
attack ovarian
tumors.
Now, patients with pancreatic cancer desperate for
new treatment options will potentially benefit from a powerful
new technology that uses genetic engineering to turn their own immune cells into «specially trained assassins» capable of finding,
attacking, and eliminating pancreatic cancer
tumors.
Now,
new research by CRI postdoctoral researcher Ingunn Stromnes, Ph.D., suggests why: pancreatic
tumors wrap themselves in a defense cloak that protects them from an immune
attack.
A novel approach to cancer immunotherapy — strategies designed to induce the immune system to
attack cancer cells — may provide a
new and cost - effective weapon against some of the most deadly
tumors, including ovarian cancer and mesothelioma.
A
new cancer - seeking compound that can trace a pancreatic
tumor's outline with exceptional clarity, then
attack cancer cells while leaving healthy tissues alone, is undergoing tests at the Roswell Park Comprehensive Cancer Center's Photodynamic Therapy Center.
Maureen Su, MD, and colleagues report on a potential
new way to fight melanoma by blocking one of the immune system's checks and balances, thus freeing immune cells to
attack tumors and kill cancer cells.
A number of research scientists
attack the problem of brain
tumors from different angles, helping to advance our understanding of cancer and identifying
new ways of fighting it.
«By bringing our research together, we want to illuminate pathways by which
tumor cells and HIV evolve to avoid immune system
attacks and use this knowledge to identify
new targets for prevention and treatment for both diseases.»
The chronically stressed mice had decreased immune function and experienced
tumor development significantly earlier than the non-stressed mice.16 Other mouse studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms
new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an
attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.
The drug represents a
new class of treatments that are made to
attack a specific type of
tumor.
Among the most promising of these
new treatments are those which
attack the functions of the
tumor itself.