Sentences with phrase «attacks on cancer cells»

Investigators have repeatedly touted the drug as a potential lynchpin in immuno - oncology, focusing on an enzyme that suppresses the immune cells Opdivo and a whole new class of PD - 1 / L1 checkpoints are designed to unleash in an attack on cancer cells.

«Over the years, we've developed the theory of «sequential cytotoxicity,» which simply means you give an initial attack on the cancer cell and then you give a second chemical attack,» Dimmock said.

The immunotherapy stimulates an immune attack on cancer cells, whereas the chemotherapy drugs directly damage tumors.

Not exact matches

Weeks later, Yee realized that he didn't have the equipment he needed to pluck out of Ziskin's blood the rare (perhaps one in 100,000) T cells that could identify the subtle peptide markers on the surface of her cancer cells and attack the disease.

The treatment is a type of so - called CAR T - cell therapy — taking a patient's own immune cells, called T cells, genetically manipulating them to attack specific proteins on cancer, and infusing them back into the patient.

On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.

One way cancer cells do this is by expressing a protein ligand that binds to a receptor on the T cells to prevent the T cell from recognizing and attacking the cancer cell.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

Targeted cancer treatments are designed to attack molecules produced by mutations, but if the targeted mutation occurs on an evolutionary branch and not the trunk, the treatment will fail as other branches dominate and treatment resistant cells spread.

Although some cancers — particularly those that are rife with mutations like lung cancer or melanoma — create more tangible targets on the surface of cells for the immune system to recognize and attack, other malignancies such as prostate and pancreatic cancers have proved more intransigent.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

But when PD - 1 binds to proteins called PD - L1 and PD - L2 on the surface of certain cancer cells, the T cells essentially become paralyzed: the immune attack on cancer is called off.

The drug's mechanism of action was entirely new: Instead of attacking cancer cells (like chemo), or indiscriminately revving up the immune system (like IL - 2), ipilimumab blocked a single receptor on one type of immune cell.

Because CTLA - 4 acts like a brake on the immune system, it prevents the body's defenses from attacking cancer cells.

Other possible ways to attack pancreatic cancer cells focus on taking away their ability to hide from the immune system.

The researchers are now looking at how ICOS signals can be altered to diminish autoimmune disorders and augmented for more effective vaccine development, and are beginning research on how ICOS signaling may benefit Chimeric Antigen Receptor - T cell (CAR - T) therapies, which involves engineering of patient's own immune cells to recognize and attack their cancers.

The reason is that some cancer cells remain even after the strongest conditioning, and the graft's attack on the host can mop up the stragglers.

T - FORCE Two T cells (orange) attack a cancer cell (blue), using special receptors to zero in on the cancer.

«Gene circuit switches on inside cancer cells, triggers immune attack: Advance may open new pathways for cancer immunotherapy.»

Working with Boise State biology professor Cheryl Jorcyk, he is looking for ways to put antibodies on the surface of the liposome, allowing them to recognize and attack cancer cells that are circulating in the body.

As seen with pseudo-coloured scanning electron microscopy, two cell - killing T - cells (red) attack a squamous mouth cancer cell (white) after a patient received a vaccine containing antigens identified on the tumour.

Researchers at Roswell Park Comprehensive Cancer Center have initiated a clinical trial based on a unique two - pronged strategy for arming the immune system to more effectively attack cancer Cancer Center have initiated a clinical trial based on a unique two - pronged strategy for arming the immune system to more effectively attack cancer cancer cells.

Conventional treatment continues to rely on chemotherapy, surgery, and radiation to attack cancer cells.

Working with a group of 16 cancer survivors, all but one of who recently finished chemotherapy cancer treatment, the researchers focused on T cells, a type of immune cell that attacks a variety of infectious agents as well as cancer cells.

Researchers at the Institut Curie in Paris now say that they have evidence of a coordinated attack on the basement membrane by cancer cells in situ and CAF cells in the extracellular matrix that begins long before the actual translocation of cancer cells.

Monoclonal antibodies are a special type of protein designed to target antigens, or markers, located on the surface of cancer cells; antibodies locate antigens and recruit immune cells to attack.

-LSB-...] Nanoparticle bullets to kill cancer cells... Posted on May 6, 2011 by Tom Harley Protein, RNA, DNA: Nanotechnology finds a multitude of paths to attack cancer cells.

Having discovered a genetic «key» (called P - TEFb) that is important in both cancer cell growth and immune cell differentiation, they tested the drugs on a mouse model for uveitis, an incurable eye condition in which the immune system mistakenly attacks healthy tissue leading to inflammation of the uvea (the middle layer of the eye).

Allison is the person responsible for developing the checkpoint blockade approach to cancer immunotherapy: antibodies are used to target specific molecules on immune cells, which empowers them to find and attack cancer cells.

Maureen Su, MD, and colleagues report on a potential new way to fight melanoma by blocking one of the immune system's checks and balances, thus freeing immune cells to attack tumors and kill cancer cells.

Researchers at Roswell Park Cancer Institute have initiated a clinical trial based on a unique two - pronged strategy for arming the immune system to more effectively attack cancer Cancer Institute have initiated a clinical trial based on a unique two - pronged strategy for arming the immune system to more effectively attack cancer cancer cells.

When it's turned on, it mobilizes certain cells, like T cells, to recognize and attack something that doesn't belong there, like cancer cells,» explains Padmanee Sharma, MD, an oncologist at MD Anderson Cancer Center in Hocancer cells,» explains Padmanee Sharma, MD, an oncologist at MD Anderson Cancer Center in HoCancer Center in Houston.

The macrophages release cytokines that can activate more innate immune cells, readying them for attack on viruses or cancer cells, or they can activate the adaptive arm of immunity, priming it for clonal expansion.

Dr Rolf Issels, M.D., Ph.D., of the University of Munich, notes that the heat produced in an infrared sauna can create «heat shock» proteins on the surfaces of cancer cells, causing them to be more vulnerable to attack by the immune system.