Sentences with phrase «atypical roles»

This move allowed him to work his charm, but didn't give the actor much room to goof or explore atypical roles.

With Jimmy Stewart in one of his most atypical roles.

Jean Arthur, in an atypical role, manages to be skittishly charming as an entertainer waiting for a boat out of town (attracted to Grant, she never leaves), and Rita Hayworth is sympathetic and impossibly pretty in her first attention - getting role, as Barthelmess's wife and Grant's former flame.

But «Hateship Loveship» is Wiig's most atypical role and turn to date, leading an ensemble cast in a drama about a family adrift in the wake of death, and the one woman who manages to keep them from completely splitting apart.

Not exact matches

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

The results reveal the central role of protein phosphorylation in the atypical cell cycle regulation of a divergent eukaryote.

Supplementing what faithful fetish chat live viewers might find to be far too pass» for their breed of folk, Mistress Preston takes on a more dominating role wherein you'll witness her engaging in leather - bridled pony play; the real - life smothering of an innocent teddy bear; enforced orgasms;» co-ed wrestling ala Andy Kaufman; panty / stocking face - sitting; armpit sniffing;» jerking a guy off with an actual pearl necklace wrapped around his wiener; taking a load of non-orthodontist recommended man - paste onto her braces; and, some other atypical activities starring cigars, balloons and shoes.

We also get appearances from James Earl Jones (who gets to be atypical and silly), as well as a stand out, but all too brief cameo from Samuel L. Jackson (in his second ever film role) as a bum who tries to hold up a fast food joint.

The atypical facial hair was for a high profile role that Hanks is currently filming: that of Walt Disney...

Nik Dodani (Atypical) also is set for a key series regular role in the reboot spearheaded by original's creator Diane English and studio Warner Bros..

A delightfully atypical choice to play a sympathetic role, for an actor often type - cast as people with arrogant or unscrupulous qualities.

You expect the racism so characters like Paul Stafford (Jim Parsons in an atypical nasty role) barely register.

May 14, 2018 • Ritter loves the complex role of the atypical superhero.

Psychology plays a huge role within the game: heroes and enemies are atypical and the line between good and evil is blurred.

At PAX East Ubisoft is showcasing a previously unreleased demo for Watch Dogs that highlights the game's atypical multiplayer by placing the player in the role of a hacker targeting another player.

This article highlights how gap year students can grow, make a real impact, and do everything with minimal costs, including exploring the role of the career counselor in this atypical choice.