Dennis Barbour, MD, PhD, associate professor of biomedical engineering in the School of Engineering & Applied Science who studies neurophysiology, found in an animal model that
auditory cortex neurons may be encoding sounds differently than previously thought.
In the current study, researchers found to their surprise that most of the nerve cells in
auditory cortex neurons that stimulate brain activity (excitatory) had signaled less (had «weaker» activity) when the mice expected and got a reward.
Not exact matches
The thinking goes that most cases of chronic tinnitus result from changes in the signals sent from the ear to
neurons in the brain's
auditory cortex.
Specialized sensory
neurons in the inner ear, called hair cells, are responsible for the detection of sounds, and this information is transmitted to the
auditory cortex via several intermediate structures.
Recording the electrical activity of
neurons directly from the surface of the brain, the scientists found that for a simple task, such as repeating a word presented visually or aurally, the visual and
auditory cortexes reacted first to perceive the word.
The team found that approximately five percent of the
neurons in the higher
auditory cortex reacted to the tutor song and that this could be indicative of where the early
auditory memory is located in the brain.
Dr. Daniel Bendor, from University College London, describes a novel way that
neurons in
auditory cortex can encode temporal information, based on how their excitatory and inhibitory inputs get mixed together.
The researchers used a technique called magnetoencephalography, which detects the firing of
neurons as changes in the brain's magnetic field, to monitor the responses of the
auditory cortex to the tones.
It is thought to be caused by a reorganisation of the brain's
auditory cortex, so too many
neurons respond to particular sound frequencies.
Sur had severed the
neurons connecting the eyes of newborn ferrets to the brain's visual
cortex; then he reconnected those same
neurons to the
auditory cortex.
Finally, the researchers tested this circuitry in live animals, artificially turning on the motor
neurons in anesthetized mice and then looking to see how the
auditory cortex responded.
Sensory
neurons, such as those in
auditory cortex, on average respond relatively indiscriminately at the beginning of a new stimulus, but rapidly become much more selective.
Each nerve hair is tuned to a particular frequency of sound and excites only certain
neurons in the
auditory cortex.
As a result, the
neurons in the
auditory cortex form what is known as a tone map.
A fetus starts to hear at about 24 weeks of gestation, as
neurons migrate to — and form connections in — the
auditory cortex, a brain region that processes sound, Stromswold explains.
When the team blocked adenosine, they saw a rise in the number of
neurons in the
auditory cortex responding to sounds.