Sentences with phrase «author on the cancer cell»
Co-senior author on the Cancer Cell study, Dr. Matthew Wilkerson, associate professor and Bioinformatics Director of The American Genome Center and the Collaborative Health Initiative Research Program at the Uniformed Services University.
https://www.sciencedaily.com/ Not exact matches
Baylin and Johns Hopkins scientist Michelle Vaz, Ph.D., first author on the study, suspected that the interplay of epigenetic and genetic changes may occur when normal lung cells develop into cancer, but, Baylin says, the timing of such changes was unknown.
The biomarker panel, enabled by discovery work of first author Jungsun Kim, PhD, a postdoctoral fellow in Zaret's lab, builds on a first - of - its - kind human - cell model of pancreatic cancer progression the lab described in 2013.
«Currently a majority of patients undergo colon resections for large polyps that don't harbor any cancer cells, which means in many cases a person's colon is being removed for noncancerous reasons, based on subjective criteria,» said lead study author Emre Gorgun, MD, FACS, FASCRS, a staff surgeon in the department of colorectal surgery, Cleveland Clinic, Ohio.
«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»
«While the presence of lymphocytes in tumors is often associated with better clinical outcomes, this research adds clarity on the diversity of T cells within the tumor environment and their influence on ovarian cancer outcomes,» says first author Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director, M. Steven Piver Professor and Chair of Gynecologic Oncology, and Executive Director of the Center for Immunotherapy at Roswell Park.
Professor Gianni Liti, a senior author on the paper from the Institute for Research on Cancer and Ageing, Nice, said: «We were able to study the evolution in time by combining genome sequences of the cell populations and tracking the growth characteristics of the yeast cells.
Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.»
Prof Hans Clevers, from Hubrecht Institute in the Netherlands, joint corresponding author on the paper, said: «Organoids had not been used to study single cancer cells before.
«With further research we hope to create a nontoxic nanocarrier that could provide targeted delivery of the TM - 025 and TM - 026 analogs specifically to cancer cells,» said Gitali Indra, an OSU assistant professor and also a lead and corresponding author on the study.
«A traditional view of chemotherapy is that you try to completely kill cancer cells and destroy tumors,» said Arup Indra, an associate professor in the OSU College of Pharmacy and one of the lead authors on the study.
«Although right now we are focusing on developing a cancer vaccine, in the future we could be able to manipulate which type of dendritic cells or other types of immune cells are recruited to the 3D scaffold by using different kinds of cytokines released from the MSRs,» said co-lead author Aileen Li, a graduate student pursuing her Ph.D. in bioengineering at Harvard SEAS.
The findings, featured on the cover of the March 7 issue of Cell Reports, show that patients with high levels of the biomarker, CD151, have a poor prognosis, says lead author Mauricio Medrano, a molecular biologist and research associate at Princess Margaret Cancer Centre, University Health Network.
The authors believe theirs is the first study to show that mouse mammary gland tissues are sensitive to a mixture of 23 commonly used UOG chemicals, with dose - specific effects on tissue morphology, cell proliferation and induction of intraductal hyperplasias, an overgrowth of cells considered a marker for future breast cancer risk.
Dr Bernardo Tavora, lead author on the paper from the Barts Cancer Institute, said: «This work shows that sensitivity to cancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothCancer Institute, said: «This work shows that sensitivity to cancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothcancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothcancer from cell - killing effects caused by radiotherapy and chemotherapy.
«This is a significant example of how knowing details of potential mechanisms and the basic science of redox active compounds in cancer versus normal cells can be leveraged clinically in cancer therapy,» says co-senior author Douglas Spitz, who focused on the biochemical studies.
Published on Sunday in the journal Nature Cell Biology, in addition to Gomis, the authors include Angel R. Nebreda, ICREA and BBVA Cancer Research Professor, and Eduard Batlle, ICREA Professor and head of the Colorectal Cancer Lab, both at IRB Barcelona.
This is our dream for personalized cancer therapy, so we're not just guessing any more about which drugs will work but can choose drug targets based on what's driving that patient's cancer,» said Josh Stuart, the Baskin professor of biomolecular engineering at UC Santa Cruz, director of cancer and stem cell genomics at the UCSC Genomics Institute, and a senior corresponding author of the paper.
Title: BRCA1 - deficient mammary tumor cells are dependent on EZH2 expression and sensitive to PCR2 - inhibitor DZNep Authors: Puppe J, Drost R, Liu X, Joosse SA, Evers B, Cornelissen - Steijger P, Nederlof P, Yu Q, Jonkers J, van Lohuizen M, Pietersen AM Date: 2009 Publication Details: Breast Cancer Research 2009, 11: R63 doi: 10.1186 / bcr2354
Based on the glycosylation targets of GalNAc - T6 in the cancer cell lines, the authors hypothesized that expression of the enzyme disrupts epithelial development in the colon by affecting cell - cell adhesion.
Both reviewers consider that since the functional studies were only tested in 2 basal and 2 luminal breast cancer cell lines, the sample set was too small, and testing additional cell lines for their dependency on MELK should further strengthen the authors conclusions.
«Knowing the cell of origin of cancer cells can provide insight into tumor subtypes and possibly diagnostic and therapeutic benefit,» says JAX Assistant Professor Jennifer Trowbridge, Ph.D., the lead author of the study published on July 11 in Nature Communications.
The lead author Xiangin Shi, PhD., professor in the Graduate Center for Toxicology at the University of Kentucky said: «What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grape seed extract fits into this category.»
«This unique strain of skin bacteria produces a chemical that kills several types of cancer cells but does not appear to be toxic to normal cells,» Richard Gallo, chair of the department of dermatology at University of California, San Diego School of Medicine, and an author on the study, said in a statement.
According to Lise Alschuler, author of the Definitive Guide To Cancer: An Integrative Approach to Prevention, Treatment, and Healing, studies on flax lignans demonstrate safety and efficacy in their use against breast cancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen&rCancer: An Integrative Approach to Prevention, Treatment, and Healing, studies on flax lignans demonstrate safety and efficacy in their use against breast cancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen&rcancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen&rcancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen».
The good news is that if markers for these tubal cells can be found, then blood tests, advanced Pap smears, or direct tests on tubal tissue might spot ovarian cancer earlier, the study authors said.