Sentences with phrase «autism risk gene»

As the autism risk gene is located on the X chromosome and males have only one X chromosome (females have two), they are at greater risk.

Page and his colleagues, who use animal models to understand how autism risk factors impact the developing brain and to identify potential treatments for the condition, have found that animals with mutations in the autism risk gene phosphatase and tensin homolog (Pten) mimic aspects of autism, including increased brain size, social deficits and increased repetitive behavior.

«This strongly suggests that, though there are hundreds of autism risk genes, the number of underlying biological mechanisms will be far fewer,» he said.

Not exact matches

But over the past decade, researchers have identified hundreds of gene variations that seem to affect brain development in ways that increase the risk of autism.

«The extensive overlap in risk genes for autism and cancer, many of which are chromatin remodeling factors, supports the idea of repurposing epigenetic drugs used in cancer treatment as targeted treatments for autism,» said Yan.

«The advantage of being able to adjust a set of genes identified as key autism risk factors may explain the strong and long - lasting efficacy of this therapeutic agent for autism.»

Previous studies have shown that inherited mutations in a gene (called TMLHE) that is required for carnitine biosynthesis are strongly associated with risk for development of autism - spectrum disorders, but the basis for that association has been unclear — until now.

Autism risk mutations inactivate this gene and, in the absence of their own ability to produce carnitine and without adequate outside supplementation, neural stem cells become less efficient at self - renewal.

The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing risk for schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorders.

Genetic studies have linked a number of risk genes to autism spectrum disorder (ASD).

The segment contains several genes, one of which raises the risk of autism.

«If there are 1,000 genes in the population that can contribute to risk in varying degrees and each has multiple developmental functions, it is not immediately obvious how to move forward to determine what is specifically related to autism,» State said.

Environment Gets More Blame for Autism: A new study suggests that environment accounts for more than half of autism risk, while genes are responsible for about 40 peAutism: A new study suggests that environment accounts for more than half of autism risk, while genes are responsible for about 40 peautism risk, while genes are responsible for about 40 percent.

Common gene variants that have minor effects may contribute about half the risk of developing autism

It may be no coincidence that many of the genes thought to increase the risk of autism are also involved in the division of cells.

In her most recent study, published in the American Journal of Medical Genetics in 2006, James found that common gene variants that support the glutathione pathway may be associated with autism risk.

A new study suggests that environment accounts for more than half of autism risk, while genes are responsible for about 40 percent.

RORA regulates many genes linked to autism, including a gene that influences prenatal testosterone levels, a known risk factor for autism.3

The newest study from the Autism Speaks MSSNG project — the world's largest autism genome sequencing program — identified an additional 18 gene variations that appear to increase the risk of aAutism Speaks MSSNG project — the world's largest autism genome sequencing program — identified an additional 18 gene variations that appear to increase the risk of aautism genome sequencing program — identified an additional 18 gene variations that appear to increase the risk of autismautism.

This particular community includes many genes associated with risk for autism.

For example, at least two of the autism - associated gene changes described in the paper were associated with increased risk for seizures.

The UCLA team also demonstrated that while autism and intellectual disability share similar risk genes, the genes behave uniquely, showing for the first time how the two disorders differ.

Earlier this year, scientists examining more than two million births in Sweden reported that inherited genes make up about 50 percent of a child's autism risk, while environmental factors make up the other half.

Rao and her team hope that pinpointing the importance of this trafficking mechanism in autism spectrum disorders may lead to the development of new drugs for autism that alter endosomal pH. As the use of genomic data becomes increasingly commonplace in the future, the step-wise strategy devised by her team can be used to screen gene variants and identify at - risk patients, she says.

«First map of autism - risk genes by function.»

They are the first to map groups of autism - risk genes by function, and to identify where and when these genes normally play major roles in early brain development.

The team speculates that the «high - risk» autism genes they carry may generate other effects in these women.

The finding wasn't surprising, Fallin explains — numerous studies have identified abnormal gene expression of immune genes in autism samples and environmental experiences such as prenatal infection or prenatal exposure to pollutants that can ramp up immune responses are risk factors for ASD.

Many genes that increase the risk of autism spectrum disorders have been identified, but their mechanisms remain largely unknown.

This approach has identified genes that are relevant to for example autism, as well as individual mutations that substantially increase or decrease the risk for e.g. cardiovascular disease.

The researchers also determined that rare inherited gene variations — those found in less than 5 % of people — contribute another 3 % of autism population risk.

Also, being homozygous for a common variant in the child's COMT (catechol - O - methyltransferase) gene was linked to over 7 times the estimated autism risk in mothers who did not take the supplements around conception time, in comparison to children with other genotypes whose mothers did take periconceptional prenatal vitamins.

Increased autism risk was also linked to other maternal gene variants related to less efficient one - carbon metabolism, but only when the mother did not take the prenatal vitamins in the early months before and immediately after conception.

Autism is a «really complicated» disorder, and the evidence to date suggests that a combination of genes and so - called environmental factors — some of which may increase the risk of both autism and schizophrenia — are involved, says Patrick F. Sullivan, M.D., lead author of the study and director of the Center for Psychiatric Genomics at the University of North Carolina School of Medicine, in ChapelAutism is a «really complicated» disorder, and the evidence to date suggests that a combination of genes and so - called environmental factors — some of which may increase the risk of both autism and schizophrenia — are involved, says Patrick F. Sullivan, M.D., lead author of the study and director of the Center for Psychiatric Genomics at the University of North Carolina School of Medicine, in Chapelautism and schizophrenia — are involved, says Patrick F. Sullivan, M.D., lead author of the study and director of the Center for Psychiatric Genomics at the University of North Carolina School of Medicine, in Chapel Hill.