Last November he reported the first results: On average,
autistic brains had many more neurons in some regions than normal brains.
Even normal brains can vary enormously in size and structure, so it was hard to see what, if anything, set
autistic brains apart.
As they develop,
autistic brains bloom with an overabundance of neurons, Courchesne finds.
He also wants to figure out why the early overgrowth in
autistic brains is followed by slowed or arrested growth.
Brainlike cell bundles grown in a lab may expose some of the biological differences of
autistic brains.
Bundles of cells hint at biological differences of
autistic brains.
As
the autistic brain grows in the womb, it bursts with an overabundance of neurons.
Although the effects evaporated after a day or two, the study shows for the first time that these parts of
the autistic brain «are not irretrievably broken,» Pelphrey says.
«
Autistic brain less flexible at taking on tasks.»
Gradually he built up a picture of
the autistic brain from infancy to adulthood, zeroing in on a crucial distinction between those who have autism and those who don't.
Scientists had done a few anatomical studies on
the autistic brain, but the results were ambiguous.
The extra neurons in
the autistic brain probably send out a vast number of extra connections to other neurons.
We have long known that autism itself is genetic, but by combining these different data sets (brain imaging and genetics) we can now identify more precisely which genes are linked to how
the autistic brain may differ.
«We discovered gene - related disruption of circuits that connect
the autistic brain's layers and hemispheres to each other,» explained Geschwind, who is director of the UCLA Neurogenetics Program and the Center for Autism Research and Treatment and co-director of the Center for Neurobehavioral Genetics at UCLA.
However, the neural basis of early overgrowth remains unknown and can only be known from direct quantitative studies of the young postmortem
autistic brain.
The mutated genes also interfered with how the brain's layers and halves relate to one another, a phenomenon confirmed by previous imaging studies of
the autistic brain.
On the other hand, dysfunctional speech - related neural processing in
the autistic brain might also denote a deficiency of oscillation coordination, based on temporal integration deficits, that reaches beyond the auditory modality.
Using interviews, blueprints, and accessible narrative, the author explains the workings of
the autistic brain while introducing the life of Temple Grandin, an autistic woman famous for her animal rights advocacy.
Not exact matches
Compounds produced in the digestive system have been linked to
autistic - type behaviour in laboratory settings, potentially demonstrating that what
autistic children eat can alter their
brain function, say scientists from the University of Western Ontario.
Also, for parents of potentially
autistic children or Adhd or other
brain diorders look up «Gut and psychology syndrome» with Dr. Natasha Campbell - McBride.
In Siegal's book The World of the
Autistic Child, it was suggested that the sleep problems faced by autistic children may also be a result of the way autistic neurotransmitters in the brain f
Autistic Child, it was suggested that the sleep problems faced by
autistic children may also be a result of the way autistic neurotransmitters in the brain f
autistic children may also be a result of the way
autistic neurotransmitters in the brain f
autistic neurotransmitters in the
brain function.
Since the
brain regulates our sleep - wake cycles,
autistic children often have trouble going to sleep and waking up at appropriate times.
STOP SIGNS Brainlike structures grown from
autistic patients» stem cells (right) produced greater numbers of
brain cells that make other
brain cells less active (green and red) compared with structures grown from the cells of a non-
autistic family member (left).
The brainlike structures created from cells taken from
autistic children showed increased activity in genes that control
brain - cell growth and development.
Miller has also seen physiological similarities in the
brains of
autistic savants and patients with frontotemporal dementia.
Imaging studies have shown that when
autistic children see a familiar face, their pattern of
brain activation is different from that of normal children.
The abnormality thus detected consists in a less deep fold in Broca's area, a region of the
brain specialized in language and communication, functions that are impaired in
autistic patients.
For a paper published in the International Journal of Psychophysiology, the researchers observed the EEG measures of 13
autistic children and 13 neurotypical children (children with a mean age of 10 years old without an intellectual deficiency or sleep problem and who were not on medication) and found that disruptions in protective
brain waves during sleep are associated with lower results on verbal IQ tests.
However, despite these similarities, the researchers noted that the relationship between these sleep waves and cognitive performance differs between neurotypical and
autistic children, as different
brain regions are involved for each group.
Autistic toddlers tend to have large
brains for their age, and researchers have shown a correlation between the degree of excess growth and the severity of autism symptoms.
At two and a half, the
autistic subjects»
brains were 7 percent larger on average than the control group's.
The authors suggest that the intricate balance between the signaling of neurons in these three
brain regions may be crucial for normal social behavior in humans, and that disruption may contribute to various psychiatric conditions, including
autistic spectrum disorders.
Situations that are normally socially rewarding fail to activate
brain - reward circuitry in
autistic children, Izuma adds, so they may also find the idea of a good social reputation less rewarding.
Instead of changing to accommodate a job, connectivity in key
brain networks of
autistic children looks similar to connectivity in the resting
brain.
These are the accumulated reflections from a lifetime spent observing the extraordinary ways the human
brain can misfire and misbehave: a man who believes his own leg does not belong to him, an
autistic woman with a gift for understanding animals, and the man who mistook his wife for a hat — the case that inspired one of Sacks's most famous books.
The finding could help researchers understand more about the relationship between
autistic traits and how the
brain adapts to problem solving in the general population.
If these mutations happen during embryonic development, there could be several neurological problems: the child could become
autistic, kids could be born with seizure disorder, or the developing neurons might not migrate to their proper site in the
brain.
The average adult human
brain weighs 1,375 grams, but Courchesne encountered one 3 - year - old
autistic boy whose
brain weight was estimated at 1,876 grams.
The involvement of this enzyme in susceptibility to oxidative stress, which has frequently been observed in
autistic children, its association with gastrointestinal diseases — which often accompany
autistic disorders — and its role in nerve development and neurotransmission mean it is an ideal candidate for deregulation of its expression to lead to the abnormal
brain development observed in ASD.
«We had
brain tissue from
autistic individuals as young as 5 and as old as 45 and we found neuroglial inflammation in all of them.
By tracking the subjects» eye movements and
brains, Dalton and Davidson found that the
autistic children spent less time fixing their gaze on the eyes in the photographs.
Courchesne suspects that fetal
brains become
autistic due to a combination of genetic and environmental influences that strike during the second and possibly third trimesters, just as neurons are dividing.
When
autistic children are born, Courchesne's research suggests, they have an abundance of neurons jammed into an average - size
brain.
Past that age, Courchesne found, the rate of
brain growth slowed in
autistic children, falling behind that of ordinary children.
In a 2005 study in the Annals of Neurology, he found inflammation in immune - responsive
brain cells of
autistic patients.
Working with the
brains of six normal children and seven
autistic children ages 2 to 16, most of whom died of drowning, Courchesne has studied neurons under the microscope and even counted the number of neural cells in different tissue samples.
Autistic children exhibited similar activity in their
brains» movement centers, but function in the mirror - neuron centers was conspicuously low.
«New studies point to autism beginning in the womb,» said Courchesne, who, with colleagues, published one such widely reported study last year detailing disrupted
brain development in post-mortem
brains of
autistic children.
This lack of interest in human speech not only correlated with the severity of a child's
autistic symptoms, Kuhl notes, but with a lack of typical
brain response to subtle changes in syllables, such as the switch from «ba» to «da.»
The most interesting thing about the results, she says, was not the correction of the
autistic symptoms in the mice, but the clues the study provided about how the gut's microbial population may affect the
brain and behavior.