β2 - glycoprotein - 1
autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model.
They found that injecting the mice with
autoantibodies from the APECED patients could inhibit the development of psoriatic pathology.
Not exact matches
Cunningham has come up with a formula based on the ratio of
autoantibodies to the two dopamine receptors; depending on the balance between the two, she can predict a variety of symptoms,
from ADD to compulsions to obsession to irritability and more.
If a patient's blood shows high levels of the markers, it indicates that neuropsychiatric symptoms could stem
from autoantibodies created in the wake of infectious disease — and that the treatment of choice might be steroids or IVIG.
When a strain of mice genetically destined to develop a form of TLR7 - dependent lupus was crossbred with a strain in which TREML4 expression was suppressed, offspring lacking TREML4 were protected
from the development of lupus - associated kidney failure and had significantly lower blood levels of inflammatory factors and
autoantibodies than did mice expressing TREML4.
However, a new study of children
from Sweden and Finland shows that the vaccine increased neither the risk of developing
autoantibodies against insulin - producing beta cells nor the occurrence of type 1 diabetes.
Rather than committing immense resources and expense to drug discovery, which is at best a very uncertain path, the findings suggest a route to drug recovery, in which naturally arising highly efficacious
autoantibodies can be isolated
from patients whose clinical information guides us as to the diseases most likely to benefit
from those antibodies.»
Researchers
from the Perelman School of Medicine at the University of Pennsylvania recently found a shared genetic link in the autoimmune response among PV patients that provides important new clues about how
autoantibodies in PV originate.
To better understand the nature of the immune response in PV, the researchers cloned anti-Dsg3 monoclonal
autoantibodies (mAbs)
from four unrelated PV patients.
We've discovered that
autoantibodies may help us identify which population benefits most
from ARB treatment,» explains Fedarko.
To investigate why the APECED patients were not developing diabetes, they compared blood samples
from eight APECED patients with type 1 diabetes with 13 APECED patients who had GAD
autoantibodies but had not developed diabetes.
ADAMTS13
autoantibodies cloned
from patients with acquired thrombotic thrombocytopenic purpura: 2.
In Stiff Person Syndrome, which is a rare autoimmune disease in the central nervous system with
autoantibodies targeting glutamic acid decarboxylase (GAD65), the humoral autoimmune response was shown to consist of a Rituximab - sensitive part rapidly cleared after treatment, and a Rituximab - resistant part
from long - lived and persistent plasma cells acting as a reservoir for secretion of
autoantibodies.
Women may also have more of a type of B cell that makes
autoantibodies that attack the body's own tissue, per research
from National Jewish Health in Denver.
Already on this post is the work of Dr. Yehuda Shoenfeld, MD, «The Mosaic of Autoimmunity: Prediction,
Autoantibodies, and Therapy in Autoimmune Diseases — 2008» located at http://www.ima.org.il/FilesUpload/IMAJ/0/42/21035.pdf paper (
from the Gluten Summit) and which is already cited on some of my tagged «microbiome» posts and the most recent «ALZHEIMER»S, DIET - MICROBIOME, & BIO-MARKER PREDICTORS» posting, http://biomeonboardawareness.com/alzheimers-diet-microbiome-bio-marker-predictors/
More autoimmune marker papers:
From Questioning Answers blog: «
Autoantibodies by the way, refers to antibodies against self tissue as per what has been noted in various autoimmune conditions / diseases,» and Paul Whiteley cites to: Plasma
Autoantibodies (Disease Associations) located at: http://www.patient.co.uk/doctor/plasma-
autoantibodies-disease-associations.
These
autoantibodies have also been found in the joints of dogs suffering
from arthritis that is not secondary to cruciate tears (Niebauer et al, 1987).
Any fluctuation
from normal thyroid levels caused by a tumor will not be the same as is seen in autoimmune thyroiditis, especially the signature sign of autoimmune disease — the
autoantibodies.