This newly discovered syndrome, dubbed the «GPIHBP1
autoantibody syndrome,» represents an important advance in understanding hypertriglyceridemia, said Dr. Stephen Young, UCLA cardiologist and molecular biologist, who led the study along with his colleagues Anne Beigneux and Loren Fong.
Not exact matches
Once they break into the brain, the
autoantibodies attack the basal ganglia, causing the afflicted to jerk and writhe in a manner resembling the worst cases of the tic
syndrome Tourette's.
In addition, they point to the potential role for using these
autoantibody tests for more widespread screening to detect this newly discovered
syndrome in other patients with type 1 diabetes.
β2 - glycoprotein - 1
autoantibodies from patients with antiphospholipid
syndrome are sufficient to potentiate arterial thrombus formation in a mouse model.
Interestingly, each of these
autoantibodies defines a
syndrome that resembles models of pharmacological or genetic disruption of the corresponding antigen.
In Stiff Person
Syndrome, which is a rare autoimmune disease in the central nervous system with
autoantibodies targeting glutamic acid decarboxylase (GAD65), the humoral autoimmune response was shown to consist of a Rituximab - sensitive part rapidly cleared after treatment, and a Rituximab - resistant part from long - lived and persistent plasma cells acting as a reservoir for secretion of
autoantibodies.
These
syndromes include conditions in which autoimmunity is clearly implicated as causal, in light of identification of
autoantibodies to relevant autoantigens; diseases suspected to be autoimmune because of the presence of
autoantibodies, although the autoreactive response has not been proven to be pathogenic and could be a consequence or marker of tissue damage; and other diseases often considered to be «autoimmune,» such as psoriasis or inflammatory bowel disease, characterized by organ - targeted inflammation but without evidence of a stimulating autoantigen.
Thyroid hormone
autoantibodies in primary Sjögren
syndrome and rheumatoid arthritis are more prevalent than in autoimmune thyroid disease, becoming progressively more frequent in these diseases.