Sentences with word «autocrine»

Further, ERK1 / 2 is known to get activated by autocrine factors without mutations in Ras [31].

By understanding how local / autocrine control of milk synthesis works, we can gain an understanding of how to effectively increase (or decrease) milk supply.

It does this, in part, by stimulating EGFR autocrine ligand shedding.

«Exercise - induced irisin may not only act as an endocrine factor capable of promoting the browning of white adipose tissue, but could also regulate bone metabolism by autocrine mechanisms,» said Chen, who also serves as faculty in the Cell, Molecular & Developmental Biology program at the Sackler School of Graduate Biomedical Sciences at Tufts.

More recently, his work has focused on understanding regulation of growth factor shedding and autocrine signaling as a mechanism by which cells interpret their microenvironment.

In NB4 cells, ATRA can induce IRF - 1, which is a transcriptional activator of IFNα expression, suggesting that ATRA may induce the RIG - G gene expression through an IFNα autocrine pathway.

Moreover, the induction of RIG - G by retinoic acid in NB4 cells resulted, to some extent, from an IFNα autocrine pathway, a finding that suggests a novel mechanism for the signal cross-talk between IFNα and retinoic acid.

Wilde CJ, Addey CV, Boddy LM, Peaker M. Autocrine regulation of milk secretion by a protein in milk.

The Herlyn lab is defining signal transduction pathways that are constitutively activated in melanoma and squamous cell cancer cells through autocrine and paracrine growth factors and genetic alterations.

Peerani et al. [31] suggested that there is a minimal colony size effect the maintenance of human ES cell pluripotency, and provided evidence that autocrine regulators of BMP and nodal signaling are key components of this regulatory pathway.

These factors, along with stem cell autocrine factors such as nodal and GDF - 3, might maintain a high local ratio of SMAD2 / 3 to SMAD1 signaling to drive stem cell maintenance.

This is called autocrine control at the local level, that is, the breast.

Autocrine activation, or stimulation, of EGFR is critical for normal HMEC function, including proliferation and motility.

Spatial organization of embryonic stem cell responsiveness to autocrine gp130 ligands reveals an autoregulatory stem cell niche.

Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose - derived mesenchymal stem cells.

Autocrine Prolactin Stimulates Endometrial Carcinoma Growth and Metastasis and Reduces Sensitivity to Chemotherapy Endocrinology February 15, 2017 Keshuo Ding, Yan Yuan, Qing - Yun Chong, Yulu Yang, Rui Li, Xiaoni Li, Xiangjun Kong, Pengxu Qian, Zirui Xiong, Vijay Pandey, Lan Ma, Zhengsheng Wu, Peter E. Lobie, and Tao Zhu Advanced and recurrent endometrial carcinoma (EC) exhibits a poor response to chemotherapy and low survival rates.

Prolactin receptors are crucial in maintaining lactation following the switch from endocrine to autocrine control [46].

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.

Recently, some other cytokines (such as tumor necrosis factor) or chemical drugs were also found to up - regulate several IFN - inducible gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.

After Lactogenesis II, there is a switch to the autocrine (or local) control system.

The first one is, that our bodies change from the endocrine to the autocrine control of lactation usually somewhere between 8 and 12 weeks.

But the other thing that happens with that pool is that: «Moms actually go from an endocrine control of lactation to an autocrine control of lactations.»

After that time it moves to the control of the autocrine system, leading some to think that milk supply can not be significantly increased after that time other than in situations like normal growth spurts.

Topics will include the role of the autocrine, paracrine and endocrine mediators in reflexes and areas of the central nervous system that are known to regulate sympathetic function.

This autocrine loop allows the leukemic cells to sidestep therapeutic inhibition of MET, shows a report published online in this week's Nature Medicine.

Angiopoietin - 2 functions as an autocrine protective factor in stressed endothelial cells.

These muscle - secreted factors have autocrine, paracrine and endocrine effects, explaining how muscles regulate metabolic homeostasis in other tissues.

Like the N - and P / Q - channels, this autocrine modulation is localized to membrane microareas.