Sentences with phrase «autocrine signaling»

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.

Not exact matches

Consequently, we conclude that the classical endotheliocentric view of Tie2 signalling with Ang1 acting in a paracrine manner and Ang2 through an autocrine loop needs to be revised in favour of a bi-directional reciprocal model in which the EC signalling is complemented reciprocally by an autocrine Ang1 / Tie2 loop in pericytes and paracrine acting Ang2 (Fig. 7).

These factors, along with stem cell autocrine factors such as nodal and GDF - 3, might maintain a high local ratio of SMAD2 / 3 to SMAD1 signaling to drive stem cell maintenance.

Peerani et al. [31] suggested that there is a minimal colony size effect the maintenance of human ES cell pluripotency, and provided evidence that autocrine regulators of BMP and nodal signaling are key components of this regulatory pathway.