Hereditary
autoimmune destruction of the thyroid gland accounts for 90 percent of cases of hypothyroidism in purebred and hybrid dog breeds, Dodds says.
In fact, toxic environmental exposure, nutritional factors, and even vaccinations have sometimes been incriminated as contributing to
autoimmune destruction of a dog's thyroid gland, known as autoimmune thyroiditis.
While in many cases we don't know the causes of an underactive thyroid gland and thyroid atrophy in dogs, in other cases there is
an autoimmune destruction of the thyroid gland by the dog's own immune system.
Granulomatous sebaceous adenitis: a disease of sebaceous (sweat) skin glands characterized by reactive tissue growth and
autoimmune destruction of the sebaceous glands.
Dry eye can be caused by a variety of causes, but the most common cause is
an autoimmune destruction of the lacrimal glands around the eye.
Autoimmune destruction of insulin - producing pancreatic β - cells is recognized as the key pathogenic feature of type 1 diabetes in patients and in the NOD mouse model (18).
Type 1 diabetes mellitus (T1D) begins with
autoimmune destruction of insulin producing cells in the pancreas, usually in children.
Autoimmune destruction of oligodendrocytes and their fatty contents gives rise to multiple sclerosis.
Not exact matches
They have been implicated in the
destruction of the BBB and are found in increased numbers in many
autoimmune diseases.
Rheumatoid arthritis is an
autoimmune condition in which the immune system attacks the joints, causing inflammation, pain, and eventually
destruction of the tissues that make up this essential body part.
Our overall goal is to prevent the
autoimmune mediated
destruction of islet beta cells.
Type I diabetes is characterized by insulin deficiency primarily caused by the
autoimmune - mediated
destruction of insulin secreting beta cells located in the pancreas.
Genetic mapping
of variants conferring a small disease risk can identify pathways in complex disorders, as exemplified by our discovery
of inherited, quantitative alterations
of CTLA4 contributing to
autoimmune tissue
destruction.
In other words, there is an
autoimmune response to gluten that has yet to cause
destruction to the villi
of the small intestine.
The major cause
of Addison's disease is
autoimmune destruction.
So, if a person have Hashimoto's, a diet high in carbs that increases thyroid hormone activity could have some great short term benefits, but could also led to an
autoimmune overreaction and an accelerated
destruction of the thyroid.
Another potential mechanism through which iodine exacerbates or induces Hashimoto's is by up - regulating Th17 cells, the immune cell subset responsible for tissue
destruction in
autoimmune disease, and by suppressing development
of regulatory T cells, the population that invokes oral tolerance to arrest
autoimmune responses (31).
With time many Hashimoto's patients do not see much difference compared to being on T4 - only medication, using desiccated thyroid or a combined T4 and T3 therapy because the
autoimmune attack and
destruction of the thyroid gland remain in progress and put them at the additional risk to develop another
autoimmune disease.
While many more people have autoimmunity, approximately 100 million progress to have
autoimmune disease, which is the point at which you have tissue
destruction and measurable signs
of disease.
Supporting the wrong side
of the immune system can result in further
destruction of the body's tissue that might be under the attack and lead to development
of other associated
autoimmune diseases.
Autoimmune diseases can result in the
destruction of body tissue (s), abnormal growth
of an organ or changes in organ function.
Some patients with Hashimoto's disease — the
autoimmune disease that causes the slow
destruction of the thyroid gland by antibodies — also go through temporary periods
of hyperthyroidism as their gland slowly becomes less functional.
In diseases, such as the different forms
of arthritis or in
autoimmune disorders like lupus or multiple sclerosis, where inflammation manifests chronically, free radicals are permanently produced and have the capacity to cause tissue
destruction.
The common identifying factor in most
autoimmune diseases is a destructive processes called inflammation which will eventually cause the
destruction of cells and tissues specific to the type
of auto - immune disease he person has.
Hypothyroidism and hyperthyroidism are often caused by
autoimmune disorders that attack the body, causing inflammation and
destruction of tissue.
Living with type 1.5 diabetes (a «slow - progressing» version
of type 1 diabetes) means that your pancreas is still capable
of producing insulin, however a weak
autoimmune reaction targets beta cells for
destruction over the course
of time.
Eating kelp, seaweed and iodized salt can actually increase the
autoimmune attack on the thyroid leading to rapid
destruction of the thyroid tissues, while limiting iodine is often helpful for reducing hypothyroidism in Hashimoto's for people with adequate or high iodine levels.
Hypoadrenocorticism: a disease where
autoimmune or other causes
of destruction of the adrenal glands produces a deficiency
of corticosteroids.
Hemolytic anemia: anemia caused by the
destruction of the red blood cells by an
autoimmune process.
A dog with a normal T4, increased cTSH, and positive TgAA will be considered to have
autoimmune thyroid disease which has been compensated for by the production
of more T4 in response to
destruction of some T4 by the antibodies, and the subsequent release
of more cTSH.
In dogs, this is the most common scenario and may be due to
destruction of pancreatic tissue (from chronic pancreatitis), an
autoimmune disease (attacking insulin - producing cells) or an unknown reason.
This latter group has the latent
autoimmune diabetes
of adults (LADA) form
of type 1 diabetes, which is characterized by gradual β - cell
destruction over months or years and is not associated with obesity (75).
SLE is an
autoimmune disease characterised by inflammation and
destruction of a variety
of tissues.
Biliary cirrhosis, also known as PBC, is an
autoimmune disease that causes the progressive
destruction of ones» bile ducts within the liver.