Sentences with phrase «autologous tier»
A second trimer, B41 SOSIP.664, also induced a strong autologous tier 2 NAb response in rabbits.
http://science.sciencemag.org/
Autologous tier 2 NAb responses in animals immunized with native - like (SOSIP.664) trimers or non-native uncleaved gp140s.
BG505 SOSIP.664 trimers consistently induced potent NAbs against the autologous tier 2 virus in rabbits and similar but weaker responses in macaques.
(Right) Autologous tier 2 serum NAb titers (IC50) in 50 animals immunized with various uncleaved gp140 proteins, compared to titers in the 30 rabbits given the BG505 or B41 SOSIP.664 trimers described here (see legend of Fig. 2 in the full article for details; P < 0.0001, two - tailed Mann - Whitney test).
Although an autologous tier 2 NAb response is not sufficient for vaccine protection against HIV - 1, it may be a necessary step in various strategies intended to induce bNAbs.
The autologous tier 2 NAb titers to both SOSIP.664 trimers were greater than any such responses previously observed using various uncleaved gp140 proteins, including the BG505 version used in this study.