Sentences with phrase «autologous transplantation»
"Autologous transplantation" refers to a medical procedure where tissues or cells are taken from a person's own body and then transplanted back into their own body. Full definition
Finally, the future success of autologous transplantation of genetically repaired or in vitro expanded organoids in patients, abolishing the need for allogeneic donors and for lifelong immunosuppression, is dependent on a significant improvement in engraftment efficiency.
mdibl.org
Patient - derived organoids offer great promise for application in the field of translational medicine, in particular for autologous transplantation and tissue regeneration purposes (4 - 6).
In autologous transplantations there are few complications once the patient leaves the hospital, and the only risk is whether the disease will return, causing relapse.
The search for new or supplementary study data in the subindication of multiple autologous transplantation produced no result: There are three large studies that are known from the publication of abstracts to have been completed for a long time.
«These findings give a rationale to start autologous transplantation — at least of neural cells — in clinical situations,» says senior author Dr. Jun Takahashi, of the Kyoto University's Center for iPS Cell Research and Application.
However, coreceptor - specific ZFNs represent a novel therapeutic approach to recapitulate this success via autologous transplantation of gene - modified hematopoietic stem cells and mature CD4 + T cells.
Plerixafor has been approved by the FDA as the first small - molecule CXCR4 antagonist for use in combination with granulocyte - colony stimulating factor (GCSF) to mobilize hematopoietic stem cells to the bloodstream for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.
The study assessed safety and efficacy of intracoronary autologous transplantation of bone marrow - derived human MSCs in patients with acute myocardial infarction.
Sustained high - level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector - transduced CD34 + cells.
In addition to the total BMSCs, there are several fractions of bone marrow - derived stem cells that are tested in clinics related to cardiac diseases, among them bone marrow - derived mononuclear cells (BM - MNCs) used mostly for autologous transplantation, CD133 + stem cells and CD34 + hematopoietic progenitors.
Peripheral blood stem cells are generally used in autologous transplantations, while either marrow or peripheral blood stem cells are used in allogeneic transplantations.
However, while the American Academy of Pediatrics believes «storing cord blood as «biological insurance» should be discouraged because there currently is no scientific data to support (self) autologous transplantation,» they DO encourage donating the blood to public banks, both for transplants and research purposes.
HSCT is effectively used today as a form of «replacement» therapy for patients with hard - to - treat blood cancers, providing healthy cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own.
When they were injected into the same monkey's brain (called an autologous transplantation), the neurons elicited only a minimal immune response.
Hematopoietic stem cells express the markers CD34 and CD133 and can repopulate a myeloablated recipient after allogeneic or autologous transplantation.
Researchers detail their assessment of the autologous transplantation of Rhesus macaque induced pluripotent stem cells and their derivatives as a relevant means to model their clinical application.
These results, published today (December 12) in Nature Biotechnology, have implications for autologous transplantation — creating a replacement tissue from a patient's own cells — something that older people are more likely to need, the authors noted.
Specific Induction of Neuronal Cells from Bone Marrow Stromal Cells and Application for Autologous Transplantation (June, 2004) in Journal of Clinical Investigation.
Although complicated, surgical procedures such as the autologous transplantation of peripheral RPE to the macular region [63]--[66] and macular translocation, where the neural retina is detached and the fovea relocated to a less diseased area of RPE [67]--[69], have been shown to stabilize visual acuity in AMD patients.