Sentences with phrase «autophagy pathway»

A defective endosomal — lysosomal autophagy pathway (due to either a primary defect in this pathway or dysfunctional mitochondria) could be the common denominator in various forms of ALS.

In this study, the researchers found that macrophages from mice lacking Smurf1 were unable to attach the death - tagging protein ubiquitin to intracellular bacteria, resulting in a failure of the autophagy pathway and runaway growth of the bacteria inside the cells.

«Finding ways to harness or enhance the autophagy pathway and Smurf1 could lead to new strategies to kill intracellular bacteria like those that cause TB,» he added.

The pioneering study, conducted by researchers from the world - leading Sheffield Institute of Translational Neuroscience (SITraN), found that the C9orf72 protein, which is encoded by the C9ORF72 gene, functions in the autophagy pathway — something which is defective in patients with the most common inherited form of ALS and FTD.

There are molecules that cause the autophagy pathway to become more active, increasing the rate at which cellular parts are recycled.

The end result of this study is that we have a list of drugs that increase the autophagy pathway in neurons.

Xavier and his colleagues have made progress in identifying small molecules in the autophagy pathway (Crohn's), and small molecules that control cytokine function and regulatory T cells (Crohn's and type 1 diabetes).