These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration;
availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
Your confirmation will indicate
the availability of funds for your specific account.
Even if such an alliance is a long shot, a president who received less than 10 percent of the African - American vote has little to lose by emphasizing the increased
availability of funds for black church social - service programs.
In spring 2010, the Health Resources and Services Administration and the Administration for Children announced
the availability of funds for the Affordable Care Act Maternal, Infant, and Early Childhood Home Visiting Program.39 The program emphasizes and supports successful implementation of high - quality home visiting programs that have demonstrated evidence of effectiveness as defined in the legislation.
Last week, NSERC President Tom Brzustowski posted a memo on the organization's Web site, stating that NSERC «can not assure
the availability of funds for successful applications for Major Installations, Major Equipment, or regular equipment (now called Research Tools and Instruments) in the upcoming competition.»
(5) Identify
the availability of funds for local charter school start - up grants and develop an application
U.S. Department of Education announces
availability of funds for assessment development through Race to the Top.
This person has been appalled at the shrinking
availability of funds for scientific research.
«We are proud to be the first bank to use Ripple's leading Blockchain network solution to power real - time payments between Japan and Thailand for our customers, whose families oftentimes depend on
the availability of these funds for basic needs — time is of the essence to them.
In spring 2010, the Health Resources and Services Administration and the Administration for Children announced
the availability of funds for the Affordable Care Act Maternal, Infant, and Early Childhood Home Visiting Program.39 The program emphasizes and supports successful implementation of high - quality home visiting programs that have demonstrated evidence of effectiveness as defined in the legislation.
The Senate passed a $ 1.1 billion deal in June, but the House's approval of its own $ 1.1 billion in funding was filibustered by Democrats, who argued that they were left out of negotiations on the bill and that the measure would take funds away from other health programs and bar
any availability of funds for birth control.
The sample size was determined by
the availability of funding for services provided to the Early Start series.
Sample size was determined by
the availability of funding for services provided to the Early Start series.
In a previous column I discussed how money from overseas is having a powerful impact on
the availability of funding for new development here in the U.S., and is extending the nation's economic recovery.
Not exact matches
Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability
of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential
for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost
of accommodating, announced increases in the build rates
of certain aircraft; 6) the effect on aircraft demand and build rates
of changing customer preferences
for business aircraft, including the effect
of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result
of global economic uncertainty or otherwise; 8) the effect
of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution
of key milestones such as the receipt
of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals
for the consummation
of our announced acquisition
of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability
of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk
of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production
of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts
of terrorism; 14) any adverse impact on the demand
for air travel or our operations from the outbreak
of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact
of future discount rate changes on pension obligations; 17) our ability to borrow additional
funds or refinance debt, including our ability to obtain the debt to finance the purchase price
for our announced acquisition
of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect
of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect
of changes in tax law, such as the effect
of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations
of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect
of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and
availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass
of highly - skilled employees and our relationships with the unions representing many
of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate
for our additional capital needs or
for payment
of interest on, and principal
of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness
of any interest rate hedging programs; 28) the effectiveness
of our internal control over financial reporting; 29) the outcome or impact
of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition
of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions
for ourselves and Asco as a result
of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks
of doing business internationally, including fluctuations in foreign current exchange rates, impositions
of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.
The
funds will also go to expanding the
availability of hotel service
for guests in cases where a ship loses power, Carnival announced Wednesday.
Among the factors that could cause actual results to differ materially are the following: (1) worldwide economic, political, and capital markets conditions and other factors beyond the Company's control, including natural and other disasters or climate change affecting the operations
of the Company or its customers and suppliers; (2) the Company's credit ratings and its cost
of capital; (3) competitive conditions and customer preferences; (4) foreign currency exchange rates and fluctuations in those rates; (5) the timing and market acceptance
of new product offerings; (6) the
availability and cost
of purchased components, compounds, raw materials and energy (including oil and natural gas and their derivatives) due to shortages, increased demand or supply interruptions (including those caused by natural and other disasters and other events); (7) the impact
of acquisitions, strategic alliances, divestitures, and other unusual events resulting from portfolio management actions and other evolving business strategies, and possible organizational restructuring; (8) generating fewer productivity improvements than estimated; (9) unanticipated problems or delays with the phased implementation
of a global enterprise resource planning (ERP) system, or security breaches and other disruptions to the Company's information technology infrastructure; (10) financial market risks that may affect the Company's
funding obligations under defined benefit pension and postretirement plans; and (11) legal proceedings, including significant developments that could occur in the legal and regulatory proceedings described in the Company's Annual Report on Form 10 - K
for the year ended Dec. 31, 2017, and any subsequent quarterly reports on Form 10 - Q (the «Reports»).
The IRRC Institute ensures the
availability of its
funded research through the sponsorship
of the Social Science Research Network's Corporate Governance Network that serves as an online repository
for thousands
of research papers and abstracts.
Mostly, there's plenty to cheer about in the ETF space;
for example, the
availability of emerging markets» sector
funds.
Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact
of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits
of such transactions, including with respect to the Merger; the substantial level
of government regulation over our business and the potential effects
of new laws or regulations or changes in existing laws or regulations; the outcome
of litigation, regulatory audits, investigations, actions and / or guaranty
fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security
of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts
of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required
for the Merger or the requirement to accept conditions that could reduce the anticipated benefits
of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration
of the businesses
of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion
of management's attention from ongoing business operations and opportunities during the pendency
of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the
availability of financing, including relating to the proposed Merger; effects on the businesses as a result
of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section
of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section
of www.express-scripts.com.
The growing
availability of credit has also expanded the resources available to new entrepreneurs launching businesses, and has given many families access to the
funds they need to «smooth over» periods
of financial challenge.9 / At the same time, competition among lenders
for individuals with solid credit histories has reduced the price
of credit
for those consumers.10 /
Winner: TD Ameritrade wins here, simply
for its wider range
of no - transaction - fee mutual
funds and the
availability of forex.
The ready
availability of funding and the high level
of profits have contributed to a favourable environment
for business.
After surveying our membership about the proposed changes to the taxation
of CCPCs and how they might affect the
availability of capital and active Angel support
for entrepreneurs, we found that possible outcomes include decreased incentive and capital
for Angels to invest and decreased access to early - stage capital, which may adversely influence the flow
of funds and resources to Canadian entrepreneurs.
Using monthly risk premium calculation data during March 1934 through June 2017 (limited by
availability of T - bill data), and monthly dividend - adjusted closing prices
for the three asset class mutual
funds during June 1980 through June 2017 (37 years, limited by VFIIX), we find that:
Examples
of these risks, uncertainties and other factors include, but are not limited to the impact
of: adverse general economic and related factors, such as fluctuating or increasing levels
of unemployment, underemployment and the volatility
of fuel prices, declines in the securities and real estate markets, and perceptions
of these conditions that decrease the level
of disposable income
of consumers or consumer confidence; adverse events impacting the security
of travel, such as terrorist acts, armed conflict and threats thereof, acts
of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread
of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment
of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to
fund our operations, and to generate the necessary amount
of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion
of our assets pledged as collateral under our existing debt agreements and the ability
of our creditors to accelerate the repayment
of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss
of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price
of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times
of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements
for crew members and other employee relation issues; the continued
availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.
A calendar
of events, maps, lodging
availability and itineraries are available at DoNapa.com, the official website and resource
for visitors which is
funded by the Napa TID.
And speaking
of farm - to - school, the USDA just announced the
availability of new federal
funds for the 2015 Farm - to - School Grant program.
Subject to the
availability of funds, mid-year applications
for financial aid may also be considered
for qualifying new students.
At 3:30 p.m., U.S. Senate candidate Chele Farley, Sen. Fred Akshar and Sheriff David E. Harder tour the Broome County Jail and hold a media
availability to address the opioid crisis and the need
for more federal
funding, Broome County Courthouse, corner
of Court and Exchange streets, Binghamton.
The added competition
for retail
funds from NS&I not only distorts the savings market, but increases the cost and reduces the
availability of mortgage
funding which building societies and other lenders rely on
for mortgage lending.
As part
of his plan
for allocating $ 5.4 billion in one - shot windfall
funds, Governor Cuomo wants to spend $ 500 million to expand the
availability and capacity
of broadband Internet access across New York.
(Posted 24 December 2011) Significant current scandals, and those yet to come In no particular order Top salaries and bonuses - boardroom and shareholder individual responsibility The multiple between top and average pay Lawyers fees - the cost
of the legal process Medical negligence claims against the NHS Care and treatment in the NHS «No win, no fee» personal injury compensation Democracy and the voting system Lords reform Political party
funding The domestic energy market and pricing The Tax system and its inefficiencies and complexities Subsidies
for new energy generation schemes The amount
of crime fuelled by Drugs The
availability of drugs in prison.
Funding, both the
availability and cost
of it, continues to cause difficulty
for mortgage lenders.
Beyond the payroll tax and charitable donation programs, Cuomo offered up ideas to reduce traffic congestion in New York City, expand
availability of flu vaccines
for children, impose restrictions on sex offenders, provide
funding for an early voting program, ban synthetic marijuana sales and target physicians who engage in medical misconduct.
Environment & Planning» Notice
of Funding Availability for Community Housing Development Organization (CHDO)
Once a drug is developed and on the market what the Global
Fund does is try to improve access to that drug
for the poorest
of poor by using advance purchasing or using commitments to try to ensure the
availability of that drug on a large scale.
Collins and Perez didn't mention, however, where the new money will come from or how or whether the change will affect the
availability of NIH
funds for other purposes, such as research grants.
The principal investigator, the direction and vision
of the PI's team, and the
availability of mentoring, the opportunity to network, and
funding and grants
for the would - be postdocs» research scored the highest rankings.
-- Subject to the
availability of appropriations,
of the
funds made available to carry out this subsection, the Secretary shall use to carry out this paragraph not less than $ 5,000,000
for fiscal year 2010 and each fiscal year thereafter.
The INF project will provide data archival and access function
for compliance to DFG regulations on
availability of data generated in DFG -
funded projects.
The position will be initially offered
for two years and further continuation are based on satisfactory performance and
availability of funds.
Enhancing the development
of innovative translational researchers in endometrial cancer is critically dependent on the
availability of flexible
funding for career enhancement projects.
And in the meantime, the free
availability of the anticipated glucosepane - detecting antibodies generated by the research that SENS Research Foundation
funded at Yale will enable the identification
of more suitable animal models
for the demonstration
of a hard health outcome.
The postdoctoral posts are available
for a fixed term
of 1 year with a possible extension
of up to 3 years, depending on performance and
funding availability.
This work is part
of a newly
funded U.S. Department
of Energy / Department
of Agriculture project led by the University
of Missouri, Columbia to explore the biology
of a single plant cell type, while gaining novel insight into the impacts
of temperature and water
availability on a crucial root cell necessary
for nutrient uptake.
FLORENCE, Italy — With its national banks teetering on the edge
of default and an uncertain economic future, Italy's financial woes have had a significant impact on state
funding for arts education and the
availability of student finance
for Italian students, creating a challenging landscape
for fashion education.
The conditions were ideal
for this groundbreaking shift: a citywide consensus that the old system had failed; a once - in - a-lifetime opportunity to build a new system from scratch; the
availability of federal school start - up
funds; and the keen interest
of education entrepreneurs, foundations, and support organizations in seeing this bold reform succeed.
School administrators plan to research the
availability of grant
funds for the high school programs.
Given the political climate and opportunities
for change — the
availability of stimulus
funds (including Secretary
of Education Arne Duncan's commitment
of $ 350 million in stimulus
funding to support assessment work), the movement toward common standards, and the upcoming reauthorization
of No Child Left Behind — we can bypass the debate between the two flawed options
of either maintaining the status quo or returning to performance - based assessment systems
of the 1990s.